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Protein
Submitted name:

Protein tyrosine phosphatase, receptor type, T

Gene

Ptprt

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei912Phosphocysteine intermediatePROSITE-ProRule annotation1
Active sitei1206Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, receptor type, TImported
Submitted name:
Protein tyrosine phosphatase, receptor type, T (Predicted)Imported
Gene namesi
Name:PtprtImported
Synonyms:Ptprt_predictedImported
ORF Names:rCG_32138Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1309653 Ptprt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei585 – 606HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000032656

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiF1LXJ9, 8 interactors
STRINGi10116.ENSRNOP00000041324

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 128MAMInterPro annotationAdd BLAST128
Domaini130 – 221Ig-likeInterPro annotationAdd BLAST92
Domaini228 – 321Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini322 – 428Fibronectin type-IIIInterPro annotationAdd BLAST107
Domaini717 – 971Tyrosine-protein phosphataseInterPro annotationAdd BLAST255
Domaini891 – 962TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1003 – 1265Tyrosine-protein phosphataseInterPro annotationAdd BLAST263
Domaini1179 – 1256TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
KOiK13297
OMAiQYEAEEV
OrthoDBiEOG091G00CK

Family and domain databases

CDDicd00063 FN3, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.40.10, 3 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR000998 MAM_dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00629 MAM, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00020 MAMDOMAIN
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00137 MAM, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequencei

Sequence statusi: Complete.

F1LXJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDPAVPTGS FMMVNSSGRA SGQKAHLLLP TLKENDTHCI DFHYYFSSRD
60 70 80 90 100
RSSPGALNVY VKVNGGPQGN PVWNVSGVVT EGWVKAELAI STFWPHFYQV
110 120 130 140 150
IFESVSLKGH PGYIAVDEVR VLAHPCRKAP HFLRLQNVEV NVGQNATFQC
160 170 180 190 200
IAGGKWSQHD KLWLQQWNGR DTALMVTRVV NHRRFSATVS VADTSQRSVS
210 220 230 240 250
KYRCVIRSDG GSGVSNYAEL IVKEPPTPIA PPELLAVGAT YLWIKPNANS
260 270 280 290 300
IIGDGPIILK EVEYRTTTGT WAETHIVDSP NYKLWHLDPD VEYEIRVLLT
310 320 330 340 350
RPGEGGTGPP GPPLTTRTKC AVPGAVPLES IQGGPFEEKI YIQWKPPNET
360 370 380 390 400
NGVITLYEIN YKAVGSLDPS ADLSSQRGKV FKLRNETHHL FVGLYPGTTY
410 420 430 440 450
SFTIKASTAK GFGPPVTTRI ATKISAPSMP EYDADSPLNE TDTTITVMLK
460 470 480 490 500
PAQSRGAPVS VYQLVVKEER LQKSRRAADI IECFSVPVSY RNASNLDSLH
510 520 530 540 550
YFAAELKPSN LPVTQPFTVG DNKTYNGYWN PPLSPLKSYS IYFQALSKAN
560 570 580 590 600
GETKINCVRL ATKGASTQNS NTVEPEKQVD NTVKMAGVIA GLLMFIIILL
610 620 630 640 650
GVMLTIKRRK LAKKQKETQS GAQREMGPVA STDKPTTKLS TNRNDEGFSS
660 670 680 690 700
SSQDVNGFTD GSRGELSQPT LTIQTHPYRT CDPVEMSYPR DQFQPAIRVA
710 720 730 740 750
DLLQHITQMK RGQGYGFKEE YEALPEGQTA SWDTAKEDEN RNKNRYGNII
760 770 780 790 800
SYDHSRVRLL VLDGDPHSDY INANYIDGYH RPRHYIATQG PMQETVKDFW
810 820 830 840 850
RMIWQENSAS IVMVTNLVEV GRVKCVRYWP DDTEVYGDIK VTLIETEPLA
860 870 880 890 900
EYVIRTFTVQ KKGYHEIREL RLFHFTSWPD HGVPCYATGL LGFVRQVKFL
910 920 930 940 950
NPPEAGPIVV HCSAGAGRTG CFIAIDTMLD MAENEGVVDI FNCVRELRAQ
960 970 980 990 1000
RVNLVQTEEQ YVFVHDAILE ACLCGNTAIP VCEFRSLYYN ISRLDPQTNS
1010 1020 1030 1040 1050
SQIKDEFQTL NIVTPRVRPE DCSIGLLPRN HDKNRSMDVL PLDRCLPFLI
1060 1070 1080 1090 1100
SVDGESSNYI NAALMDSHKQ PAAFVVTQHP LPNTVADFWR LVFDYNCSSV
1110 1120 1130 1140 1150
VMLNEMDTAQ LCMQYWPEKT SGCYGPIQVE FVSADIDEDI IHRIFRICNM
1160 1170 1180 1190 1200
ARPQDGYRIV QHLQYIGWPA YRDTPPSKRS LLKAVRRLEK WQEEYDGREG
1210 1220 1230 1240 1250
RTVVHCLNGG GRSGTFCAIC SVCEMIQQQN IIDVFHIVKT LRNNKSNMVE
1260
TLEQYKFVYE VALEYLSSF
Length:1,269
Mass (Da):142,502
Last modified:April 3, 2013 - v2
Checksum:i10BBC37791D23BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054502 Genomic DNA No translation available.
AABR07054503 Genomic DNA No translation available.
AABR07054504 Genomic DNA No translation available.
AABR07054505 Genomic DNA No translation available.
AABR07054506 Genomic DNA No translation available.
AABR07054507 Genomic DNA No translation available.
CH474005 Genomic DNA Translation: EDL96606.1
RefSeqiNP_001102073.1, NM_001108603.1
UniGeneiRn.198665

Genome annotation databases

EnsembliENSRNOT00000044466; ENSRNOP00000041324; ENSRNOG00000032656
GeneIDi362263
KEGGirno:362263

Similar proteinsi

Entry informationi

Entry nameiF1LXJ9_RAT
AccessioniPrimary (citable) accession number: F1LXJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health