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Protein

Sodium channel protein

Gene

Scn3a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn3aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3635. Scn3a.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14724HelicalUniRule annotationAdd
BLAST
Transmembranei192 – 21120HelicalUniRule annotationAdd
BLAST
Transmembranei223 – 24422HelicalUniRule annotationAdd
BLAST
Transmembranei250 – 27021HelicalUniRule annotationAdd
BLAST
Transmembranei400 – 42728HelicalUniRule annotationAdd
BLAST
Transmembranei712 – 73019HelicalUniRule annotationAdd
BLAST
Transmembranei742 – 76524HelicalUniRule annotationAdd
BLAST
Transmembranei822 – 85029HelicalUniRule annotationAdd
BLAST
Transmembranei912 – 93524HelicalUniRule annotationAdd
BLAST
Transmembranei1158 – 117619HelicalUniRule annotationAdd
BLAST
Transmembranei1197 – 121923HelicalUniRule annotationAdd
BLAST
Transmembranei1225 – 124521HelicalUniRule annotationAdd
BLAST
Transmembranei1274 – 130027HelicalUniRule annotationAdd
BLAST
Transmembranei1395 – 141925HelicalUniRule annotationAdd
BLAST
Transmembranei1478 – 149619HelicalUniRule annotationAdd
BLAST
Transmembranei1508 – 152619HelicalUniRule annotationAdd
BLAST
Transmembranei1533 – 155826HelicalUniRule annotationAdd
BLAST
Transmembranei1595 – 162329HelicalUniRule annotationAdd
BLAST
Transmembranei1699 – 172224HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiF1LX08.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005007.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 434308Ion_transInterPro annotationAdd
BLAST
Domaini507 – 624118Na_trans_cytoplInterPro annotationAdd
BLAST
Domaini712 – 940229Ion_transInterPro annotationAdd
BLAST
Domaini949 – 1151203Na_trans_assocInterPro annotationAdd
BLAST
Domaini1156 – 1427272Ion_transInterPro annotationAdd
BLAST
Domaini1477 – 1732256Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili424 – 46542Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
OMAiYFNGTMD.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

F1LX08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD
310 320 330 340 350
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY
360 370 380 390 400
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY
410 420 430 440 450
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE
460 470 480 490 500
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR
510 520 530 540 550
NRRKKRRQRE HLEGNHRADG DRFPKSESED SVKRRSFLLS LDGNPLTGDK
560 570 580 590 600
KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
610 620 630 640 650
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS
660 670 680 690 700
SGRQRAMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV
710 720 730 740 750
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTQQFS SVLTVGNLVF
760 770 780 790 800
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV
810 820 830 840 850
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV
860 870 880 890 900
GMQLFGKSYK ECVCKINVDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW
910 920 930 940 950
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN
960 970 980 990 1000
EMNNLQIAVG RMQKGIDFVK NKIRECFRKA FFRKPKVIEI QEGNKIDSCM
1010 1020 1030 1040 1050
SNNTGIEISK ELNYLKDGNG TTSGVGTGSS VEKYVIDEND YMSFINNPSL
1060 1070 1080 1090 1100
TVTVPIAVGE SDFENLNTEE FSSESELEES KEKLNATSSS EGSTVDVAPP
1110 1120 1130 1140 1150
REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG KIWWNLRKTC
1160 1170 1180 1190 1200
YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY
1210 1220 1230 1240 1250
IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA
1260 1270 1280 1290 1300
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF
1310 1320 1330 1340 1350
SIMGVNLFAG KFYHCVNTTT GNMFEIKEVN NFSDCQALGK QARWKNVKVN
1360 1370 1380 1390 1400
FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RDVKLQPIYE ENLYMYLYFV
1410 1420 1430 1440 1450
IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPANKFQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD
1510 1520 1530 1540 1550
QSKYMTLVLS RINLVFIVLF TGEFLLKLIS LRYYYFTIGW NIFDFVVVIL
1560 1570 1580 1590 1600
SIVGMFLAEL IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM
1610 1620 1630 1640 1650
MSLPALFNIG LLLFLVMFIY AIFGMSNFAY VKKEAGIDDM FNFETFGNSM
1660 1670 1680 1690 1700
ICLFQITTSA GWDGLLAPIL NSAPPDCDPD AIHPGSSVKG DCGNPSVGIF
1710 1720 1730 1740 1750
FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD FEMFYEVWEK
1760 1770 1780 1790 1800
FDPDATQFIE FCKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC
1810 1820 1830 1840 1850
LDILFAFTKR VLGESGEMDA LRIQMEERFM ASNPSKVSYE PITTTLKRKQ
1860 1870 1880 1890 1900
EEVSAAIIQR NYRCYLLKQR LKNISSKYDK ETIKGRIDLP IKGDMVIDKL
1910 1920 1930 1940 1950
NGNSTPEKTD GSSSTTSPPS YDSVTKPDKE KFEKDKPEKE IKGKEVRENQ

K
Length:1,951
Mass (Da):221,411
Last modified:July 22, 2015 - v3
Checksum:i74B08700B0EDD42B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07052405 Genomic DNA. No translation available.
RefSeqiXP_008760141.1. XM_008761919.1.
UniGeneiRn.87394.

Genome annotation databases

EnsembliENSRNOT00000006646; ENSRNOP00000006646; ENSRNOG00000005007.
ENSRNOT00000081401; ENSRNOP00000072091; ENSRNOG00000005007.
GeneIDi497770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07052405 Genomic DNA. No translation available.
RefSeqiXP_008760141.1. XM_008761919.1.
UniGeneiRn.87394.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006646.

Proteomic databases

PRIDEiF1LX08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006646; ENSRNOP00000006646; ENSRNOG00000005007.
ENSRNOT00000081401; ENSRNOP00000072091; ENSRNOG00000005007.
GeneIDi497770.

Organism-specific databases

CTDi6328.
RGDi3635. Scn3a.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.
OMAiYFNGTMD.
TreeFamiTF323985.

Gene expression databases

BgeeiENSRNOG00000005007.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiF1LX08_RAT
AccessioniPrimary (citable) accession number: F1LX08
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 7, 2016
This is version 50 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.