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F1LX08

- F1LX08_RAT

UniProt

F1LX08 - F1LX08_RAT

Protein

Sodium channel protein

Gene

Scn3a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel proteinUniRule annotation
    Gene namesi
    Name:Scn3aImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi3635. Scn3a.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiF1LX08.

    Structurei

    3D structure databases

    ProteinModelPortaliF1LX08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00560000076721.
    OMAiSYFNGTM.
    OrthoDBiEOG7DJSK9.
    TreeFamiTF323985.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028808. Na_channel_a3su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LX08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK     50
    PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF 100
    RFSATSALYI LTPLNPVRKI AIKILKPSLL HMLIMCTILT NCVFMTLSNP 150
    PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM 200
    AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
    MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD 300
    SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY 350
    ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY 400
    MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE 450
    QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR 500
    NRRKKRRQRE HLEGNHRADG DRFPKSESED SVKRRSFLLS LDGNPLTGDK 550
    KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
    FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS 650
    SGRQRAMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV 700
    KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTQQFS SVLTVGNLVF 750
    TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV 800
    LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV 850
    GMQLFGKSYK ECVCKINVDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
    DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN 950
    EMNNLQIAVG RMQKGIDFVK NKIRECFRKA FFRKPKVIEI QEGNKIDSCM 1000
    SNNTGIEISK ELNYLKDGNG TTSGVGTGSS VEKYVIDEND YMSFINNPSL 1050
    TVTVPIAVGE SDFENLNTEE FSSESELEES KEKLNATSSS EGSTVDVAPP 1100
    REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG KIWWNLRKTC 1150
    YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY 1200
    IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA 1250
    IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 1300
    SIMGVNLFAG KFYHCVNTTT GNMFEIKEVN NFSDCQALGK QARWKNVKVN 1350
    FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RDVKLQPIYE ENLYMYLYFV 1400
    IFIIFGSFFT LNLFIGVIID NFNQQKKKMS QDIFMTEEQK KYYNAMKKLG 1450
    SKKPQKPIPR PANKFQGMVF DFVTRQVFDI SIMILICLNM VTMMVETDDQ 1500
    SKYMTLVLSR INLVFIVLFT GEFLLKLISL RYYYFTIGWN IFDFVVVILS 1550
    IVGMFLAELI EKYFVSPTLF RVIRLARIGR ILRLIKGAKG IRTLLFALMM 1600
    SLPALFNIGL LLFLVMFIYA IFGMSNFAYV KKEAGIDDMF NFETFGNSMI 1650
    CLFQITTSAG WDGLLAPILN SAPPDCDPDA IHPGSSVKGD CGNPSVGIFF 1700
    FVSYIIISFL VVVNMYIAVI LENFSVATEE SAEPLSEDDF EMFYEVWEKF 1750
    DPDATQFIEF CKLSDFAAAL DPPLLIAKPN KVQLIAMDLP MVSGDRIHCL 1800
    DILFAFTKRV LGESGEMDAL RIQMEERFMA SNPSKVSYEP ITTTLKRKQE 1850
    EVSAAIIQRN YRCYLLKQRL KNISSKYDKE TIKGRIDLPI KGDMVIDKLN 1900
    GNSTPEKTDG SSSTTSPPSY DSVTKPDKEK FEKDKPEKEI KGKEVRENQK 1950
    Length:1,950
    Mass (Da):221,373
    Last modified:April 3, 2013 - v2
    Checksum:i90D501C5DE778995
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06023824 Genomic DNA. No translation available.
    AABR06023825 Genomic DNA. No translation available.
    AABR06023826 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000006646; ENSRNOP00000006646; ENSRNOG00000005007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06023824 Genomic DNA. No translation available.
    AABR06023825 Genomic DNA. No translation available.
    AABR06023826 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F1LX08.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1LX08.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006646 ; ENSRNOP00000006646 ; ENSRNOG00000005007 .

    Organism-specific databases

    RGDi 3635. Scn3a.

    Phylogenomic databases

    GeneTreei ENSGT00560000076721.
    OMAi SYFNGTM.
    OrthoDBi EOG7DJSK9.
    TreeFami TF323985.

    Miscellaneous databases

    NextBioi 35578636.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028808. Na_channel_a3su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LX08_RAT
    AccessioniPrimary (citable) accession number: F1LX08
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 32 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3