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F1LX08

- F1LX08_RAT

UniProt

F1LX08 - F1LX08_RAT

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Protein

Sodium channel protein

Gene
Scn3a
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn3aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi3635. Scn3a.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiF1LX08.

Structurei

3D structure databases

ProteinModelPortaliF1LX08.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00560000076721.
OMAiSYFNGTM.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LX08-1 [UniParc]FASTAAdd to Basket

« Hide

MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK     50
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF 100
RFSATSALYI LTPLNPVRKI AIKILKPSLL HMLIMCTILT NCVFMTLSNP 150
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM 200
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD 300
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY 350
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY 400
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE 450
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR 500
NRRKKRRQRE HLEGNHRADG DRFPKSESED SVKRRSFLLS LDGNPLTGDK 550
KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS 650
SGRQRAMSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV 700
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTQQFS SVLTVGNLVF 750
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV 800
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV 850
GMQLFGKSYK ECVCKINVDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN 950
EMNNLQIAVG RMQKGIDFVK NKIRECFRKA FFRKPKVIEI QEGNKIDSCM 1000
SNNTGIEISK ELNYLKDGNG TTSGVGTGSS VEKYVIDEND YMSFINNPSL 1050
TVTVPIAVGE SDFENLNTEE FSSESELEES KEKLNATSSS EGSTVDVAPP 1100
REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG KIWWNLRKTC 1150
YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY 1200
IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA 1250
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 1300
SIMGVNLFAG KFYHCVNTTT GNMFEIKEVN NFSDCQALGK QARWKNVKVN 1350
FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RDVKLQPIYE ENLYMYLYFV 1400
IFIIFGSFFT LNLFIGVIID NFNQQKKKMS QDIFMTEEQK KYYNAMKKLG 1450
SKKPQKPIPR PANKFQGMVF DFVTRQVFDI SIMILICLNM VTMMVETDDQ 1500
SKYMTLVLSR INLVFIVLFT GEFLLKLISL RYYYFTIGWN IFDFVVVILS 1550
IVGMFLAELI EKYFVSPTLF RVIRLARIGR ILRLIKGAKG IRTLLFALMM 1600
SLPALFNIGL LLFLVMFIYA IFGMSNFAYV KKEAGIDDMF NFETFGNSMI 1650
CLFQITTSAG WDGLLAPILN SAPPDCDPDA IHPGSSVKGD CGNPSVGIFF 1700
FVSYIIISFL VVVNMYIAVI LENFSVATEE SAEPLSEDDF EMFYEVWEKF 1750
DPDATQFIEF CKLSDFAAAL DPPLLIAKPN KVQLIAMDLP MVSGDRIHCL 1800
DILFAFTKRV LGESGEMDAL RIQMEERFMA SNPSKVSYEP ITTTLKRKQE 1850
EVSAAIIQRN YRCYLLKQRL KNISSKYDKE TIKGRIDLPI KGDMVIDKLN 1900
GNSTPEKTDG SSSTTSPPSY DSVTKPDKEK FEKDKPEKEI KGKEVRENQK 1950
Length:1,950
Mass (Da):221,373
Last modified:April 3, 2013 - v2
Checksum:i90D501C5DE778995
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06023824 Genomic DNA. No translation available.
AABR06023825 Genomic DNA. No translation available.
AABR06023826 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000006646; ENSRNOP00000006646; ENSRNOG00000005007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06023824 Genomic DNA. No translation available.
AABR06023825 Genomic DNA. No translation available.
AABR06023826 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F1LX08.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1LX08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006646 ; ENSRNOP00000006646 ; ENSRNOG00000005007 .

Organism-specific databases

RGDi 3635. Scn3a.

Phylogenomic databases

GeneTreei ENSGT00560000076721.
OMAi SYFNGTM.
OrthoDBi EOG7DJSK9.
TreeFami TF323985.

Miscellaneous databases

NextBioi 35578636.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028808. Na_channel_a3su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LX08_RAT
AccessioniPrimary (citable) accession number: F1LX08
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: July 9, 2014
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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