Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Indoleamine 2,3-dioxygenase 2

Gene

Ido2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Involved in immune regulation.By similarity

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.By similarity

Enzyme regulationi

Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan).By similarity

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 1 of the subpathway that synthesizes L-kynurenine from L-tryptophan.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (Tdo2), Indoleamine 2,3-dioxygenase 2 (Ido2)
  2. Kynurenine formamidase (Afmid)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi347 – 3471Iron (heme proximal ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Immunity, Tryptophan catabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-71240. Tryptophan catabolism.
UniPathwayiUPA00333; UER00453.

Names & Taxonomyi

Protein namesi
Recommended name:
Indoleamine 2,3-dioxygenase 2 (EC:1.13.11.-By similarity)
Short name:
IDO-2
Alternative name(s):
Indoleamine 2,3-dioxygenase-like protein 1
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Gene namesi
Name:Ido2
Synonyms:Indol1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1596771. Ido2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Indoleamine 2,3-dioxygenase 2PRO_0000434002Add
BLAST

Proteomic databases

PaxDbiF1LV46.
PeptideAtlasiF1LV46.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025365.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036799.

Family & Domainsi

Sequence similaritiesi

Belongs to the indoleamine 2,3-dioxygenase family.Curated

Phylogenomic databases

eggNOGiENOG410IGEY. Eukaryota.
ENOG410XQHE. LUCA.
InParanoidiF1LV46.
KOiK00463.
OrthoDBiEOG091G0DCU.
TreeFamiTF330978.

Family and domain databases

InterProiIPR000898. Indolamine_dOase.
[Graphical view]
PfamiPF01231. IDO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LV46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAQRQDGKL ASSLSLGKYH ISEEYGFLLP NPLEELPDHY KPWMEIAHRL
60 70 80 90 100
PHLIESHQLQ AHVYEMPLLD CRFLTSYREQ RLAHLVLAAI TMGFVWQEGE
110 120 130 140 150
AQPQKVLPRT LAIPFVEVSR SLGLPPILVH SDLVLTNWTK RNPEGPLEIG
160 170 180 190 200
NLETIISFPG GESLQGFILV TVLVEKAAVP GIKALVLGVE AIRQHSQDTL
210 220 230 240 250
LEALQQLRLS IQDITRALAQ MHDYVDPEIF YLVIRIFLSG WKDNPVMPVG
260 270 280 290 300
LVYEGVSTEP LKYSGGSAAQ SSVLHAFDEF LGIQHCKESV DFLHRMRDYM
310 320 330 340 350
PPSHKAFLED LHSAPSLRDY ILDSGPGGCL MAYNQCVEAL GELRSYHINM
360 370 380 390 400
VARYIISAAS KARSRMLTRL SPHALEDRGT GGTAVLSFLK SVREKTMEAI

LCPGA
Length:405
Mass (Da):45,236
Last modified:October 14, 2015 - v4
Checksum:i5CAE75E87ECAD42F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ109047 mRNA. No translation available.
AABR07026331 Genomic DNA. No translation available.
AABR07026332 Genomic DNA. No translation available.
RefSeqiXP_003752968.1. XM_003752920.3.

Genome annotation databases

GeneIDi681319.
KEGGirno:681319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ109047 mRNA. No translation available.
AABR07026331 Genomic DNA. No translation available.
AABR07026332 Genomic DNA. No translation available.
RefSeqiXP_003752968.1. XM_003752920.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036799.

Proteomic databases

PaxDbiF1LV46.
PeptideAtlasiF1LV46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi681319.
KEGGirno:681319.

Organism-specific databases

CTDi169355.
RGDi1596771. Ido2.

Phylogenomic databases

eggNOGiENOG410IGEY. Eukaryota.
ENOG410XQHE. LUCA.
InParanoidiF1LV46.
KOiK00463.
OrthoDBiEOG091G0DCU.
TreeFamiTF330978.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00453.
ReactomeiR-RNO-71240. Tryptophan catabolism.

Miscellaneous databases

PROiF1LV46.

Gene expression databases

BgeeiENSRNOG00000025365.

Family and domain databases

InterProiIPR000898. Indolamine_dOase.
[Graphical view]
PfamiPF01231. IDO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI23O2_RAT
AccessioniPrimary (citable) accession number: F1LV46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: October 14, 2015
Last modified: September 7, 2016
This is version 42 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ido1 and Ido2 are 2 distinct enzymes which catalyze the same reaction. Ido2 affinity for tryptophan is much lower than that of Ido1. Ido2 may play a role as a negative regulator of Ido1 by competing for heme-binding with Ido1. Low efficiency Ido2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency Ido1 enzymes are dispensable in many lower vertebrate lineages. Ido1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.