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Protein

Indoleamine 2,3-dioxygenase 2

Gene

Ido2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Involved in immune regulation.By similarity

Miscellaneous

Ido1 and Ido2 are 2 distinct enzymes which catalyze the same reaction. Ido2 affinity for tryptophan is much lower than that of Ido1. Ido2 may play a role as a negative regulator of Ido1 by competing for heme-binding with Ido1. Low efficiency Ido2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency Ido1 enzymes are dispensable in many lower vertebrate lineages. Ido1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals.By similarity

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.By similarity

Enzyme regulationi

Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan).By similarity

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 1 of the subpathway that synthesizes L-kynurenine from L-tryptophan.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (Tdo2), Indoleamine 2,3-dioxygenase 2 (Ido2)
  2. Kynurenine formamidase (Afmid)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi347Iron (heme proximal ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processImmunity, Tryptophan catabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00333; UER00453

Names & Taxonomyi

Protein namesi
Recommended name:
Indoleamine 2,3-dioxygenase 2 (EC:1.13.11.-By similarity)
Short name:
IDO-2
Alternative name(s):
Indoleamine 2,3-dioxygenase-like protein 1
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Gene namesi
Name:Ido2
Synonyms:Indol1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1596771 Ido2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004340021 – 405Indoleamine 2,3-dioxygenase 2Add BLAST405

Proteomic databases

PaxDbiF1LV46
PeptideAtlasiF1LV46

Expressioni

Gene expression databases

BgeeiENSRNOG00000025365

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036799

Structurei

3D structure databases

ProteinModelPortaliF1LV46
SMRiF1LV46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the indoleamine 2,3-dioxygenase family.Curated

Phylogenomic databases

eggNOGiENOG410IGEY Eukaryota
ENOG410XQHE LUCA
InParanoidiF1LV46
KOiK00463
OrthoDBiEOG091G0DCU
TreeFamiTF330978

Family and domain databases

InterProiView protein in InterPro
IPR000898 Indolamine_dOase
IPR037217 Trp/Indoleamine_2_3_dOase-like
PANTHERiPTHR28657 PTHR28657, 1 hit
PfamiView protein in Pfam
PF01231 IDO, 1 hit
SUPFAMiSSF140959 SSF140959, 1 hit

Sequencei

Sequence statusi: Complete.

F1LV46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAQRQDGKL ASSLSLGKYH ISEEYGFLLP NPLEELPDHY KPWMEIAHRL
60 70 80 90 100
PHLIESHQLQ AHVYEMPLLD CRFLTSYREQ RLAHLVLAAI TMGFVWQEGE
110 120 130 140 150
AQPQKVLPRT LAIPFVEVSR SLGLPPILVH SDLVLTNWTK RNPEGPLEIG
160 170 180 190 200
NLETIISFPG GESLQGFILV TVLVEKAAVP GIKALVLGVE AIRQHSQDTL
210 220 230 240 250
LEALQQLRLS IQDITRALAQ MHDYVDPEIF YLVIRIFLSG WKDNPVMPVG
260 270 280 290 300
LVYEGVSTEP LKYSGGSAAQ SSVLHAFDEF LGIQHCKESV DFLHRMRDYM
310 320 330 340 350
PPSHKAFLED LHSAPSLRDY ILDSGPGGCL MAYNQCVEAL GELRSYHINM
360 370 380 390 400
VARYIISAAS KARSRMLTRL SPHALEDRGT GGTAVLSFLK SVREKTMEAI

LCPGA
Length:405
Mass (Da):45,236
Last modified:October 14, 2015 - v4
Checksum:i5CAE75E87ECAD42F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ109047 mRNA No translation available.
AABR07026331 Genomic DNA No translation available.
AABR07026332 Genomic DNA No translation available.
RefSeqiXP_003752968.1, XM_003752920.3

Genome annotation databases

GeneIDi681319
KEGGirno:681319

Similar proteinsi

Entry informationi

Entry nameiI23O2_RAT
AccessioniPrimary (citable) accession number: F1LV46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: October 14, 2015
Last modified: May 23, 2018
This is version 50 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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