ID   F1LU96_RAT              Unreviewed;      1910 AA.
AC   F1LU96;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=NCK-associated protein 5 {ECO:0000313|Ensembl:ENSRNOP00000029665.6};
GN   Name=Nckap5 {ECO:0000313|Ensembl:ENSRNOP00000029665.6,
GN   ECO:0000313|RGD:1564507};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000029665.6, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000029665.6, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029665.6,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000029665.6}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029665.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017454529.1; XM_017599040.1.
DR   AlphaFoldDB; F1LU96; -.
DR   STRING; 10116.ENSRNOP00000029665; -.
DR   PaxDb; 10116-ENSRNOP00000029665; -.
DR   Ensembl; ENSRNOT00000038020.7; ENSRNOP00000029665.6; ENSRNOG00000021553.8.
DR   GeneID; 363974; -.
DR   AGR; RGD:1564507; -.
DR   CTD; 344148; -.
DR   RGD; 1564507; Nckap5.
DR   VEuPathDB; HostDB:ENSRNOG00000021553; -.
DR   eggNOG; ENOG502QWN7; Eukaryota.
DR   GeneTree; ENSGT00530000063607; -.
DR   HOGENOM; CLU_002885_0_0_1; -.
DR   InParanoid; F1LU96; -.
DR   OMA; RRDWAQC; -.
DR   TreeFam; TF331208; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000021553; Expressed in lung and 13 other cell types or tissues.
DR   GO; GO:0035371; C:microtubule plus-end; IBA:GO_Central.
DR   GO; GO:0001578; P:microtubule bundle formation; IBA:GO_Central.
DR   GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR   InterPro; IPR032769; NCKAP5_C.
DR   InterPro; IPR026163; Nckap5l.
DR   PANTHER; PTHR21740; NCK-ASSOCIATED PROTEIN 5; 1.
DR   PANTHER; PTHR21740:SF0; NCK-ASSOCIATED PROTEIN 5; 1.
DR   Pfam; PF15246; NCKAP5; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN          1434..1735
FT                   /note="Nck-associated protein 5 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15246"
FT   REGION          119..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          706..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          772..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          854..1434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1451..1573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1612..1656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1683..1841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1854..1910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          189..248
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        131..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..743
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        793..817
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        854..872
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        938..964
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        971..1000
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1024..1105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1144..1159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1203..1217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1265..1304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1314..1334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1345..1359
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1376..1431
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1491..1534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1536..1566
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1612..1628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1629..1646
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1719..1751
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1765..1789
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1815..1836
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1860..1877
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1894..1910
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1910 AA;  209322 MW;  F3A0C033E5FBD860 CRC64;
     MEGKRQLDRR DFGKRLSLDS SLVEYMDSNK CIEHLLAQLR EQHRSLWREK LAVARLQREV
     AQRTSQGAMQ EKLIHELEEE RQLRLQSEER LREVTLESER NRIQMLGLQQ QFSRMEETVR
     SLLQSQGSPE QKKEEPAKIT AYQERVSEEE RKEQAALGDL RVEADEDSRS EHSSTEGGKE
     DSRLLLKRLK ALEAENSALA LENENQREQY ERCLDEVANQ VVRALLTQKD LREECVKLKT
     RVFDLEQQNR ALSILFQQRV RPASDVLLQE HLQNAKSGAP ALKHSGSGVV IPDHPCPRNS
     CSSGSELSLS STCSEYSSGS SYTWQDRKLN GKRQTSQIWD KRLSIDSSLP SGFTSPADEL
     PPTRIKESHI LEGLRKLQKR KVLLESPASV MSKWGYKDCM NSNEGIYSPG IKNSSLKECP
     PCQSPGRGIP CQNLHQTFNY DANSHEYAHE EFLSSASPRT SPSQGCRIQS SKLTHSVSDS
     LFTWEPHRKY FAEGTASVYT REMPERLTRC ASHCPLERKL CPSVHLPWVQ RDRDPHSQGP
     GHVPLNLQLS DTDDNETLHE LHIESSDERS PSDLSLTGDT DRSMENLGVK FGKSECVSHD
     KGKEECPTHL ETSPKAFSFI KQQRVVKRTS SEECVTVIFD AENGEPVEFS SHQAGVVTVT
     RDEISISSTP AGPSEELTEL SPQGITHFQP GATARDYPFL GRPEEEPKTN IPKDENGILT
     APNDSFNSPT TVTQNSPRPK LVKPTQGVAW QSNSRSVANM SVYTKQGLTK IPSRSKISPQ
     KSKLVDPMPT TLVPSSGLGT LAKTPASPTG KLSQCTNAES PGTFCDVQPE SHIPKHPTQL
     PHIPKISNKK NWVQCPKSQT AGIQSRHLMG KSDNGESPTR AKRCGSEPKT RMRSPSPPTP
     PGRSVSLLVR PSYDYPPLPS PAKPETKAPG DTVSTGLKSP VLKGSSAPLV SSSPAMSEIQ
     KKPSVASRKS AFPTALPSTQ AVVHTRYPEH TSSSPFAVTA PGPTKVSPKR GIPKAPHPQA
     LGTTHMDTDL QTPKTRPSSY ELLEMTSCKN LSPGRKGQLS DSTVTPHRPS FSGPNEFLTP
     QVNSTSSSSS SCRNQGTSQG GQNPPEKGPK TRLPVGLRVL MKSPQLLRKT SMVPGKQEKD
     SLNEASRSSV TANKSNPEDS KDPASLETSR DERTTALLGL RGPESLARGL GLESTPPESL
     ESSISRDDGR DGVDSRAIKR SFSSSKPHLK PALGMNGAKA RSQSFSFHLG EKPSTPPIEG
     PGKIRTQIIT NTAERGNSLT RQNISMEGSP SKTPSVSTPD NLPNAGRPLG NPFSRQGSLC
     STGSSSSQHG SPSKLPLRML TRPEGLLTPE EEDQRFSTQE ECPGRGVHEQ SSSNHHRHPS
     STLSDCPQSL QVPGRIQRPS NLETNGISKL ETSGRHPDAS PTGTSVVSPE APLSPSIEEK
     VMLCIQENVE KGQAQTKSAS VEVKPRAGPS FTSWFGFRKS RLPALSSRRM EASKSKVEKK
     DTKLKSERKK EKKKAEVQSK RENELSRGTK KADGQSPDDG LQNTESLKAT QDIYNQMKSE
     PRNRPSPAVS PTKDAFMTEL LNRVDKRAAL QTESGSKGVS CRSVLEGTSQ GSCFASGSVS
     TQGSQKKNIK TKVDMEKPRE SLGAEVDEDV REDEEDRVAD AALQSHVIES NCQMRTLDSG
     IGTFPLPDSG NRSMGRYICQ QDSPEDTDPL LPLQPAPSMP SSARAQTLDR EVPSSTDSQS
     SSESTIIHSV SDPSMMARGI RASQSHLPKP TTSGKTSFEK QNGAESKATT GPSFEYAEDA
     VPSEPLSGWR GEDATTENQE LKQVEETKED PENRLSEISL ESFNKFNSNT VILLEKEQSP
     SEVEGQKEEK GKETEVSLSS SDRPGVDHVE SLSDSLYDSF SSCASQTSNA
//