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Protein
Submitted name:

Natural resistance-associated macrophage protein 1

Gene

Slc11a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in response to bacteria.
R-RNO-425410. Metal ion SLC transporters.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-6803544. Ion influx/efflux at host-pathogen interface.

Names & Taxonomyi

Protein namesi
Submitted name:
Natural resistance-associated macrophage protein 1Imported
Gene namesi
Name:Slc11a1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1601463. Slc11a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 67HelicalSequence analysisAdd BLAST20
Transmembranei124 – 143HelicalSequence analysisAdd BLAST20
Transmembranei155 – 173HelicalSequence analysisAdd BLAST19
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei236 – 262HelicalSequence analysisAdd BLAST27
Transmembranei301 – 327HelicalSequence analysisAdd BLAST27
Transmembranei354 – 373HelicalSequence analysisAdd BLAST20
Transmembranei393 – 411HelicalSequence analysisAdd BLAST19
Transmembranei423 – 445HelicalSequence analysisAdd BLAST23
Transmembranei451 – 472HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF1LSN8.
PRIDEiF1LSN8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014956.
ExpressionAtlasiF1LSN8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054282.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1291. Eukaryota.
COG1914. LUCA.
GeneTreeiENSGT00390000006526.

Family and domain databases

HAMAPiMF_00221. NRAMP. 1 hit.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LSN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW
60 70 80 90 100
VLLWATVLGL LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA
110 120 130 140 150
IVGSDMQEVI GTAISFNLLS AGRIPLWGGV LITIVDTFFF LFLDNYGLRK
160 170 180 190 200
LEAFFGFLIT IMALTFGYEY VVARPSQGAL LKGLFLPSCP GCGQPELLQA
210 220 230 240 250
VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF LTEATIALFV
260 270 280 290 300
SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD
310 320 330 340 350
IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR
360 370 380 390 400
WSRFARVLLT RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL
410 420 430 440 450
PILTFTSMPA VMQEFANGWL SKVITSCIMA LVCAINLYFV ISYLPSLPHP
460 470 480 490 500
AYFGLVALLA IGYLGLTAYL AWTCCIAHGA KFLTHSSHQR FLYGLPIEEQ

EGREGSG
Length:507
Mass (Da):55,936
Last modified:May 3, 2011 - v1
Checksum:i66AA452FBBEA12BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07068077 Genomic DNA. No translation available.
AABR07068078 Genomic DNA. No translation available.
AABR07068079 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000057472; ENSRNOP00000054282; ENSRNOG00000014956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07068077 Genomic DNA. No translation available.
AABR07068078 Genomic DNA. No translation available.
AABR07068079 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054282.

Proteomic databases

PaxDbiF1LSN8.
PRIDEiF1LSN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057472; ENSRNOP00000054282; ENSRNOG00000014956.

Organism-specific databases

RGDi1601463. Slc11a1.

Phylogenomic databases

eggNOGiKOG1291. Eukaryota.
COG1914. LUCA.
GeneTreeiENSGT00390000006526.

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in response to bacteria.
R-RNO-425410. Metal ion SLC transporters.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-6803544. Ion influx/efflux at host-pathogen interface.

Gene expression databases

BgeeiENSRNOG00000014956.
ExpressionAtlasiF1LSN8. baseline and differential.

Family and domain databases

HAMAPiMF_00221. NRAMP. 1 hit.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF1LSN8_RAT
AccessioniPrimary (citable) accession number: F1LSN8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 30, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.