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F1LSN8

- F1LSN8_RAT

UniProt

F1LSN8 - F1LSN8_RAT

Protein
Submitted name:

Natural resistance-associated macrophage protein 1

Gene

Slc11a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. manganese ion transmembrane transporter activity Source: Ensembl
    2. metal ion:proton antiporter activity Source: Ensembl

    GO - Biological processi

    1. activation of protein kinase activity Source: Ensembl
    2. antigen processing and presentation of peptide antigen Source: Ensembl
    3. cadmium ion transmembrane transport Source: Ensembl
    4. cellular cadmium ion homeostasis Source: Ensembl
    5. cellular iron ion homeostasis Source: Ensembl
    6. defense response to Gram-negative bacterium Source: Ensembl
    7. defense response to protozoan Source: Ensembl
    8. divalent metal ion export Source: Ensembl
    9. inflammatory response Source: Ensembl
    10. interleukin-2 production Source: Ensembl
    11. interleukin-3 production Source: Ensembl
    12. iron ion transport Source: Ensembl
    13. L-arginine import Source: Ensembl
    14. macrophage activation Source: Ensembl
    15. MHC class II biosynthetic process Source: Ensembl
    16. mRNA stabilization Source: Ensembl
    17. multicellular organismal iron ion homeostasis Source: Ensembl
    18. negative regulation of cytokine production Source: Ensembl
    19. nitrite transport Source: Ensembl
    20. phagocytosis Source: Ensembl
    21. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
    22. positive regulation of interferon-gamma production Source: Ensembl
    23. positive regulation of phagocytosis Source: Ensembl
    24. positive regulation of T-helper 1 type immune response Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. protein import into nucleus, translocation Source: Ensembl
    27. respiratory burst Source: Ensembl
    28. response to interferon-gamma Source: Ensembl
    29. T cell cytokine production Source: Ensembl
    30. T cell proliferation involved in immune response Source: Ensembl
    31. vacuolar acidification Source: Ensembl
    32. wound healing Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196741. Phagosomal maturation (early endosomal stage).

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Natural resistance-associated macrophage protein 1Imported
    Gene namesi
    Name:Slc11a1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1601463. Slc11a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: Ensembl
    2. endosome membrane Source: Ensembl
    3. late endosome Source: Ensembl
    4. lysosome Source: Ensembl
    5. phagocytic vesicle membrane Source: Ensembl
    6. plasma membrane Source: Ensembl
    7. tertiary granule membrane Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000006526.
    OMAiTSMPTLM.
    OrthoDBiEOG77127K.

    Family and domain databases

    HAMAPiMF_00221. NRAMP.
    InterProiIPR001046. NRAMP_fam.
    [Graphical view]
    PANTHERiPTHR11706. PTHR11706. 1 hit.
    PfamiPF01566. Nramp. 1 hit.
    [Graphical view]
    PRINTSiPR00447. NATRESASSCMP.
    TIGRFAMsiTIGR01197. nramp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F1LSN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW    50
    VLLWATVLGL LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA 100
    IVGSDMQEVI GTAISFNLLS AGRIPLWGGV LITIVDTFFF LFLDNYGLRK 150
    LEAFFGFLIT IMALTFGYEY VVARPSQGAL LKGLFLPSCP GCGQPELLQA 200
    VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF LTEATIALFV 250
    SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD 300
    IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR 350
    WSRFARVLLT RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL 400
    PILTFTSMPA VMQEFANGWL SKVITSCIMA LVCAINLYFV ISYLPSLPHP 450
    AYFGLVALLA IGYLGLTAYL AWTCCIAHGA KFLTHSSHQR FLYGLPIEEQ 500
    EGREGSG 507
    Length:507
    Mass (Da):55,936
    Last modified:May 3, 2011 - v1
    Checksum:i66AA452FBBEA12BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06061095 Genomic DNA. No translation available.
    AABR06061096 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000057472; ENSRNOP00000054282; ENSRNOG00000014956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06061095 Genomic DNA. No translation available.
    AABR06061096 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000057472 ; ENSRNOP00000054282 ; ENSRNOG00000014956 .

    Organism-specific databases

    RGDi 1601463. Slc11a1.

    Phylogenomic databases

    GeneTreei ENSGT00390000006526.
    OMAi TSMPTLM.
    OrthoDBi EOG77127K.

    Enzyme and pathway databases

    Reactomei REACT_196741. Phagosomal maturation (early endosomal stage).

    Miscellaneous databases

    NextBioi 35577140.

    Family and domain databases

    HAMAPi MF_00221. NRAMP.
    InterProi IPR001046. NRAMP_fam.
    [Graphical view ]
    PANTHERi PTHR11706. PTHR11706. 1 hit.
    Pfami PF01566. Nramp. 1 hit.
    [Graphical view ]
    PRINTSi PR00447. NATRESASSCMP.
    TIGRFAMsi TIGR01197. nramp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LSN8_RAT
    AccessioniPrimary (citable) accession number: F1LSN8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3