F1LSN8 (F1LSN8_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Natural resistance-associated macrophage protein 1 Ensembl ENSRNOP00000054282

Gene names

Name:

Slc11a1 Ensembl ENSRNOP00000054282 RGD 1601463

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000054282

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000054282

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-arginine import Inferred from electronic annotation. Source: Compara MHC class II biosynthetic process Inferred from electronic annotation. Source: Compara T cell cytokine production Inferred from electronic annotation. Source: Compara T cell proliferation involved in immune response Inferred from electronic annotation. Source: Compara activation of protein kinase activity Inferred from electronic annotation. Source: Compara antigen processing and presentation of peptide antigen Inferred from electronic annotation. Source: Compara cadmium ion transmembrane transport Inferred from electronic annotation. Source: Compara cellular cadmium ion homeostasis Inferred from electronic annotation. Source: Compara cellular iron ion homeostasis Inferred from electronic annotation. Source: Compara defense response to Gram-negative bacterium Inferred from electronic annotation. Source: Compara defense response to protozoan Inferred from electronic annotation. Source: Compara divalent metal ion export Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara interleukin-2 production Inferred from electronic annotation. Source: Compara interleukin-3 production Inferred from electronic annotation. Source: Compara iron ion transport Inferred from electronic annotation. Source: Compara mRNA stabilization Inferred from electronic annotation. Source: Compara macrophage activation Inferred from electronic annotation. Source: Compara multicellular organismal iron ion homeostasis Inferred from electronic annotation. Source: Compara negative regulation of cytokine production Inferred from electronic annotation. Source: Compara nitrite transport Inferred from electronic annotation. Source: Compara phagocytosis Inferred from electronic annotation. Source: Compara positive regulation of T-helper 1 type immune response Inferred from electronic annotation. Source: Compara positive regulation of dendritic cell antigen processing and presentation Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of phagocytosis Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara respiratory burst Inferred from electronic annotation. Source: Compara response to interferon-gamma Inferred from electronic annotation. Source: Compara vacuolar acidification Inferred from electronic annotation. Source: Compara wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: Compara endosome membrane Inferred from electronic annotation. Source: Compara late endosome Inferred from electronic annotation. Source: Compara lysosome Inferred from electronic annotation. Source: Compara phagocytic vesicle membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara tertiary granule membrane Inferred from electronic annotation. Source: Compara
Molecular_function	manganese ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara metal ion:hydrogen antiporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F1LSN8 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 66AA452FBBEA12BE	FASTA	507	55,936
	10 20 30 40 50 60 MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW VLLWATVLGL 70 80 90 100 110 120 LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA IVGSDMQEVI GTAISFNLLS 130 140 150 160 170 180 AGRIPLWGGV LITIVDTFFF LFLDNYGLRK LEAFFGFLIT IMALTFGYEY VVARPSQGAL 190 200 210 220 230 240 LKGLFLPSCP GCGQPELLQA VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF 250 260 270 280 290 300 LTEATIALFV SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD 310 320 330 340 350 360 IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR WSRFARVLLT 370 380 390 400 410 420 RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL PILTFTSMPA VMQEFANGWL 430 440 450 460 470 480 SKVITSCIMA LVCAINLYFV ISYLPSLPHP AYFGLVALLA IGYLGLTAYL AWTCCIAHGA 490 500 KFLTHSSHQR FLYGLPIEEQ EGREGSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000054282.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000054282.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06061095 Genomic DNA. No translation available. AABR06061096 Genomic DNA. No translation available.
IPI	IPI00362939.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000057472; ENSRNOP00000054282; ENSRNOG00000014956.
Organism-specific databases
RGD	1601463. Slc11a1.
Phylogenomic databases
GeneTree	ENSGT00390000006526.
Gene expression databases
ArrayExpress	F1LSN8.
Family and domain databases
InterPro	IPR001046. Nat-R-assoc-macro_Nramp. [Graphical view]
PANTHER	PTHR11706. PTHR11706. 1 hit.
Pfam	PF01566. Nramp. 1 hit. [Graphical view]
PRINTS	PR00447. NATRESASSCMP.
TIGRFAMs	TIGR01197. nramp. 1 hit.
ProtoNet	Search...
Other
NextBio	35577140.

Entry information

Entry name

F1LSN8_RAT

Accession

Primary (citable) accession number: F1LSN8

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)