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Protein
Submitted name:

Natural resistance-associated macrophage protein 1

Gene

Slc11a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. manganese ion transmembrane transporter activity Source: Ensembl
  2. metal ion:proton antiporter activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase activity Source: Ensembl
  2. antigen processing and presentation of peptide antigen Source: Ensembl
  3. cadmium ion transmembrane transport Source: Ensembl
  4. cellular cadmium ion homeostasis Source: Ensembl
  5. cellular iron ion homeostasis Source: Ensembl
  6. defense response to Gram-negative bacterium Source: Ensembl
  7. defense response to protozoan Source: Ensembl
  8. divalent metal ion export Source: Ensembl
  9. inflammatory response Source: Ensembl
  10. interleukin-2 production Source: Ensembl
  11. interleukin-3 production Source: Ensembl
  12. iron ion transport Source: Ensembl
  13. L-arginine import Source: Ensembl
  14. macrophage activation Source: Ensembl
  15. MHC class II biosynthetic process Source: Ensembl
  16. mRNA stabilization Source: Ensembl
  17. multicellular organismal iron ion homeostasis Source: Ensembl
  18. negative regulation of cytokine production Source: Ensembl
  19. nitrite transport Source: Ensembl
  20. phagocytosis Source: Ensembl
  21. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
  22. positive regulation of interferon-gamma production Source: Ensembl
  23. positive regulation of phagocytosis Source: Ensembl
  24. positive regulation of T-helper 1 type immune response Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  26. protein import into nucleus, translocation Source: Ensembl
  27. respiratory burst Source: Ensembl
  28. response to interferon-gamma Source: Ensembl
  29. T cell cytokine production Source: Ensembl
  30. T cell proliferation involved in immune response Source: Ensembl
  31. vacuolar acidification Source: Ensembl
  32. wound healing Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196741. Phagosomal maturation (early endosomal stage).
REACT_254464. Metal ion SLC transporters.

Names & Taxonomyi

Protein namesi
Submitted name:
Natural resistance-associated macrophage protein 1Imported
Gene namesi
Name:Slc11a1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1601463. Slc11a1.

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: Ensembl
  2. endosome membrane Source: Ensembl
  3. late endosome Source: Ensembl
  4. lysosome Source: Ensembl
  5. phagocytic vesicle membrane Source: Ensembl
  6. plasma membrane Source: Ensembl
  7. tertiary granule membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000006526.
OMAiTSMPTLM.
OrthoDBiEOG77127K.

Family and domain databases

HAMAPiMF_00221. NRAMP.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LSN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW
60 70 80 90 100
VLLWATVLGL LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA
110 120 130 140 150
IVGSDMQEVI GTAISFNLLS AGRIPLWGGV LITIVDTFFF LFLDNYGLRK
160 170 180 190 200
LEAFFGFLIT IMALTFGYEY VVARPSQGAL LKGLFLPSCP GCGQPELLQA
210 220 230 240 250
VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF LTEATIALFV
260 270 280 290 300
SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD
310 320 330 340 350
IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR
360 370 380 390 400
WSRFARVLLT RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL
410 420 430 440 450
PILTFTSMPA VMQEFANGWL SKVITSCIMA LVCAINLYFV ISYLPSLPHP
460 470 480 490 500
AYFGLVALLA IGYLGLTAYL AWTCCIAHGA KFLTHSSHQR FLYGLPIEEQ

EGREGSG
Length:507
Mass (Da):55,936
Last modified:May 3, 2011 - v1
Checksum:i66AA452FBBEA12BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061095 Genomic DNA. No translation available.
AABR06061096 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000057472; ENSRNOP00000054282; ENSRNOG00000014956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061095 Genomic DNA. No translation available.
AABR06061096 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057472; ENSRNOP00000054282; ENSRNOG00000014956.

Organism-specific databases

RGDi1601463. Slc11a1.

Phylogenomic databases

GeneTreeiENSGT00390000006526.
OMAiTSMPTLM.
OrthoDBiEOG77127K.

Enzyme and pathway databases

ReactomeiREACT_196741. Phagosomal maturation (early endosomal stage).
REACT_254464. Metal ion SLC transporters.

Miscellaneous databases

NextBioi35577140.

Family and domain databases

HAMAPiMF_00221. NRAMP.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LSN8_RAT
AccessioniPrimary (citable) accession number: F1LSN8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 7, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.