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F1LSH3

- F1LSH3_RAT

UniProt

F1LSH3 - F1LSH3_RAT

Protein
Submitted name:

Origin recognition complex subunit 3

Gene

Orc3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA replication Source: InterPro
    2. neural precursor cell proliferation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_204904. Activation of ATR in response to replication stress.
    REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
    REACT_208829. Assembly of the pre-replicative complex.
    REACT_209879. Activation of the pre-replicative complex.
    REACT_211117. Orc1 removal from chromatin.
    REACT_212543. Removal of licensing factors from origins.
    REACT_213976. CDC6 association with the ORC:origin complex.
    REACT_215168. Assembly of the ORC complex at the origin of replication.
    REACT_223712. Association of licensing factors with the pre-replicative complex.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Origin recognition complex subunit 3Imported
    Gene namesi
    Name:Orc3Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1308457. Orc3.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear origin of replication recognition complex Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000011376.
    OMAiCFVFKPN.
    OrthoDBiEOG78PV8B.
    TreeFamiTF101093.

    Family and domain databases

    InterProiIPR020795. ORC3.
    [Graphical view]
    PANTHERiPTHR12748. PTHR12748. 1 hit.
    PfamiPF07034. ORC3_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LSH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSSVSKGC FVFKPDFKKR KISVPIEDYF NNEELDSEDS KLRFETYRLL    50
    WQRIKSETEQ LQEGLNENLF DNLVDFLQKS HSELQKNSGN WGSQMRLREI 100
    PTAALILGVN VTDHDVIFRS LTETLHNNVT PYVVSLQAKD CPDVKHFLQK 150
    LTSELIDCCV DRNSKEEKND KALRRTSYSM DSLSSWYSTV AQKTGPKMTS 200
    KKRATCSQWQ SPPVVLILKN MESFSTKVLQ DFIIISSQHL HEFPLILIFG 250
    IATSPVIIHR LLPHSVSSLL CIELFQSLSC KEHLTVVLDK LLLTPQFPFK 300
    LSKKALQVLT NIFLYHDFSI QNFIKGLKLS LLEHFYSQPL SVLCCDLSEA 350
    KKRINVFSVN QCEKIRRLPS FRRYVENQPL EKQVALLTNE TFLKEETQSL 400
    LEDLHVYHIN YFLVLRCLHN FTSSLPKYPL GRQIRELYCT CLEKKIWDSE 450
    EYESALQLLR MLAKDELMGI LEQCVKVLNS STEKQLSNTA QKIKGFLTQF 500
    QNLDDSKEEE DACGSQPKGL QKTDLYHLQK SLLEMKELRR TTKKPTKFEM 550
    LRENVINFID NLVRDYLLPP EGQPLHEVVY FSAANTLREH LNAAPRIALH 600
    TALNNPYYYL KNEALKSEEG CIPSVAPDIC IAYKLHLECS RLINLVDWSE 650
    AFATVVTAAE KMDTNSTVSE EMSEIIHARF IRAVSELELL GFIKPTKQKT 700
    DHVARLTWGG C 711
    Length:711
    Mass (Da):81,867
    Last modified:April 3, 2013 - v2
    Checksum:i25DB9E205C0333A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06036451 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000011085; ENSRNOP00000011085; ENSRNOG00000008314.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06036451 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011085 ; ENSRNOP00000011085 ; ENSRNOG00000008314 .

    Organism-specific databases

    RGDi 1308457. Orc3.

    Phylogenomic databases

    GeneTreei ENSGT00390000011376.
    OMAi CFVFKPN.
    OrthoDBi EOG78PV8B.
    TreeFami TF101093.

    Enzyme and pathway databases

    Reactomei REACT_204904. Activation of ATR in response to replication stress.
    REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
    REACT_208829. Assembly of the pre-replicative complex.
    REACT_209879. Activation of the pre-replicative complex.
    REACT_211117. Orc1 removal from chromatin.
    REACT_212543. Removal of licensing factors from origins.
    REACT_213976. CDC6 association with the ORC:origin complex.
    REACT_215168. Assembly of the ORC complex at the origin of replication.
    REACT_223712. Association of licensing factors with the pre-replicative complex.

    Miscellaneous databases

    NextBioi 35577080.
    PROi F1LSH3.

    Family and domain databases

    InterProi IPR020795. ORC3.
    [Graphical view ]
    PANTHERi PTHR12748. PTHR12748. 1 hit.
    Pfami PF07034. ORC3_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LSH3_RAT
    AccessioniPrimary (citable) accession number: F1LSH3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 23 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3