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F1LSH3

- F1LSH3_RAT

UniProt

F1LSH3 - F1LSH3_RAT

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Protein
Submitted name:

Origin recognition complex subunit 3

Gene

Orc3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA binding Source: InterPro

GO - Biological processi

  1. DNA replication Source: InterPro
  2. neural precursor cell proliferation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_204904. Activation of ATR in response to replication stress.
REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
REACT_208829. Assembly of the pre-replicative complex.
REACT_209879. Activation of the pre-replicative complex.
REACT_211117. Orc1 removal from chromatin.
REACT_212543. Removal of licensing factors from origins.
REACT_213976. CDC6 association with the ORC:origin complex.
REACT_215168. Assembly of the ORC complex at the origin of replication.
REACT_223712. Association of licensing factors with the pre-replicative complex.
REACT_252682. E2F-enabled inhibition of pre-replication complex formation.

Names & Taxonomyi

Protein namesi
Submitted name:
Origin recognition complex subunit 3Imported
Gene namesi
Name:Orc3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi1308457. Orc3.

Subcellular locationi

GO - Cellular componenti

  1. nuclear origin of replication recognition complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000011376.
OMAiCFVFKPN.
OrthoDBiEOG78PV8B.
TreeFamiTF101093.

Family and domain databases

InterProiIPR020795. ORC3.
[Graphical view]
PANTHERiPTHR12748. PTHR12748. 1 hit.
PfamiPF07034. ORC3_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LSH3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSSVSKGC FVFKPDFKKR KISVPIEDYF NNEELDSEDS KLRFETYRLL
60 70 80 90 100
WQRIKSETEQ LQEGLNENLF DNLVDFLQKS HSELQKNSGN WGSQMRLREI
110 120 130 140 150
PTAALILGVN VTDHDVIFRS LTETLHNNVT PYVVSLQAKD CPDVKHFLQK
160 170 180 190 200
LTSELIDCCV DRNSKEEKND KALRRTSYSM DSLSSWYSTV AQKTGPKMTS
210 220 230 240 250
KKRATCSQWQ SPPVVLILKN MESFSTKVLQ DFIIISSQHL HEFPLILIFG
260 270 280 290 300
IATSPVIIHR LLPHSVSSLL CIELFQSLSC KEHLTVVLDK LLLTPQFPFK
310 320 330 340 350
LSKKALQVLT NIFLYHDFSI QNFIKGLKLS LLEHFYSQPL SVLCCDLSEA
360 370 380 390 400
KKRINVFSVN QCEKIRRLPS FRRYVENQPL EKQVALLTNE TFLKEETQSL
410 420 430 440 450
LEDLHVYHIN YFLVLRCLHN FTSSLPKYPL GRQIRELYCT CLEKKIWDSE
460 470 480 490 500
EYESALQLLR MLAKDELMGI LEQCVKVLNS STEKQLSNTA QKIKGFLTQF
510 520 530 540 550
QNLDDSKEEE DACGSQPKGL QKTDLYHLQK SLLEMKELRR TTKKPTKFEM
560 570 580 590 600
LRENVINFID NLVRDYLLPP EGQPLHEVVY FSAANTLREH LNAAPRIALH
610 620 630 640 650
TALNNPYYYL KNEALKSEEG CIPSVAPDIC IAYKLHLECS RLINLVDWSE
660 670 680 690 700
AFATVVTAAE KMDTNSTVSE EMSEIIHARF IRAVSELELL GFIKPTKQKT
710
DHVARLTWGG C
Length:711
Mass (Da):81,867
Last modified:April 3, 2013 - v2
Checksum:i25DB9E205C0333A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06036451 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000011085; ENSRNOP00000011085; ENSRNOG00000008314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06036451 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011085 ; ENSRNOP00000011085 ; ENSRNOG00000008314 .

Organism-specific databases

RGDi 1308457. Orc3.

Phylogenomic databases

GeneTreei ENSGT00390000011376.
OMAi CFVFKPN.
OrthoDBi EOG78PV8B.
TreeFami TF101093.

Enzyme and pathway databases

Reactomei REACT_204904. Activation of ATR in response to replication stress.
REACT_206997. CDT1 association with the CDC6:ORC:origin complex.
REACT_208829. Assembly of the pre-replicative complex.
REACT_209879. Activation of the pre-replicative complex.
REACT_211117. Orc1 removal from chromatin.
REACT_212543. Removal of licensing factors from origins.
REACT_213976. CDC6 association with the ORC:origin complex.
REACT_215168. Assembly of the ORC complex at the origin of replication.
REACT_223712. Association of licensing factors with the pre-replicative complex.
REACT_252682. E2F-enabled inhibition of pre-replication complex formation.

Miscellaneous databases

NextBioi 35577080.
PROi F1LSH3.

Family and domain databases

InterProi IPR020795. ORC3.
[Graphical view ]
PANTHERi PTHR12748. PTHR12748. 1 hit.
Pfami PF07034. ORC3_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LSH3_RAT
AccessioniPrimary (citable) accession number: F1LSH3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: November 26, 2014
This is version 24 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3