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Protein
Submitted name:

DNA mismatch repair protein Mlh1

Gene

Mlh1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Names & Taxonomyi

Protein namesi
Submitted name:
DNA mismatch repair protein Mlh1Imported
Gene namesi
Name:Mlh1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620937 Mlh1

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSRNOG00000033809
ExpressionAtlasiF1LSD8 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 335DNA_mis_repairInterPro annotationAdd BLAST120

Phylogenomic databases

eggNOGiKOG1979 Eukaryota
COG0323 LUCA
GeneTreeiENSGT00800000124177

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR013507 DNA_mismatch_repair_C
IPR014762 DNA_mismatch_repair_CS
IPR002099 DNA_mismatch_repair_fam
IPR011186 DNA_mismatch_repair_MLH1
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR032189 Mlh1_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073:SF40 PTHR10073:SF40, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF16413 Mlh1_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

Sequencei

Sequence statusi: Complete.

F1LSD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTNIQVI
60 70 80 90 100
VKEGGLKLIQ IQDNGTGIRK EDLDIVCERF TTSKLQTFED LASISTYGFR
110 120 130 140 150
GEALASISHV AHVTITTKTA DGKCAYRASY SDGKLQAPPK PCAGNQGTLI
160 170 180 190 200
TVEDLFYNII TRRKALKNPS EEYGKILEVV GRYSIHNSGI SFSVKKQGET
210 220 230 240 250
VSDVRTLPNA TTVDNIRSIF GNAVSRELIE VGCEDKTLAF KMNGYISNAN
260 270 280 290 300
YSVKKCIFLL FINHRLVESA ALKKAIEAVY AAYLPKNTHP FLYLSLEISP
310 320 330 340 350
QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP
360 370 380 390 400
GLAGPSGEAV KSTTGIASSS TSGSGDKVHA YQMVRTDSRD QKLDAFMQPV
410 420 430 440 450
SRRLPSQPQD PVPGNRTEGS PEKAMQKDQE MSELPAAMEA AADSASLERE
460 470 480 490 500
SVIGASEVAP QRHPSSPGSS RKRHREDSDE EMMENDSRKE MTAACYPRRR
510 520 530 540 550
IINLTSVLSL QEEINDRGHE TLREMLRNHT FVGCVNPQWA LAQHQTKLYL
560 570 580 590 600
LNTTKLSEEL FYQILIYDFA NFGVLRLSEP APLFDLAMLA LDSPESGWTE
610 620 630 640 650
EDGPKEGLAE YIVEFLKKKA EMLADYFSVE IDEEGNLIGL PLLIDSYVPP
660 670 680 690 700
LEGLPIFILR LATEVNWDEE KECFESLSKE CAVFYSIRKQ YILEESALSG
710 720 730 740 750
QQSDMPGSPS KPWKWTVEHI IYKAFRSHLL PPKHFTEDGN VLQLANLPDL

YKVFERC
Length:757
Mass (Da):84,593
Last modified:May 3, 2011 - v1
Checksum:iF77BCE7C6161958A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122675 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000064581; ENSRNOP00000061834; ENSRNOG00000033809

Similar proteinsi

Entry informationi

Entry nameiF1LSD8_RAT
AccessioniPrimary (citable) accession number: F1LSD8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health