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Protein
Submitted name:

Glutathione reductase

Gene

Gsr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: RGD
  • glutathione binding Source: RGD
  • glutathione-disulfide reductase activity Source: RGD
  • NADP binding Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • glutathione metabolic process Source: RGD
  • response to ethanol Source: RGD
  • response to nicotine Source: RGD
  • response to vitamin A Source: RGD
  • spermatogenesis Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_304258. Synthesis and interconversion of nucleotide di- and triphosphates.
REACT_317923. Detoxification of Reactive Oxygen Species.
REACT_358301. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutathione reductaseImported
Gene namesi
Name:GsrImported
ORF Names:rCG_43149Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621747. Gsr.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: Ensembl
  • mitochondrion Source: RGD
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020252.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000007578.
KOiK00383.
OMAiSFDPMII.
OrthoDBiEOG7HHWS0.
TreeFamiTF105353.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01421. gluta_reduc_1. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LRE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNTAVHSEF IHDHVDYGFQ NCKSKFNWHV IKEKRDAYVS RLNNIYQNNL
60 70 80 90 100
TKSHIEVIHG YATFADGPQP TVEVNGKKFT APHILIATGG VPTVPHENQI
110 120 130 140 150
PGASLGITSD GFFQLEDLPS RSVIVGAGYI AVEIAGILSA LGSKTSLMIR
160 170 180 190 200
HDKVLRSFDS LISSNCTEEL ENAGVEVLKF SQVKEVKKTP SGLELHVVTA
210 220 230 240 250
LPGRKPTVTT IPDVDCLLWA IGRDPNSKGL NLNKLGIQTD DKGHILVDEF
260 270 280 290 300
QNTNVKGVYA VGDVCGKALL TPVAIAAGRK LAHRLFEGKE DSRLDYDNIP
310 320 330 340 350
TVVFSHPPIG TVGLTEDEAV HKYGKDNVKI YSTAFTPMYH AVTTRKTKCV
360 370 380 390 400
MKMVCANKEE KVVGIHMQGI GCDEMLQGFA VAVKMGATKA DFDNTVAIHP
410
TSSEELVTLR
Length:410
Mass (Da):44,789
Last modified:April 3, 2013 - v2
Checksum:iD433AAEDEB6D9BA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06088698 Genomic DNA. No translation available.
CH473970 Genomic DNA. Translation: EDM09143.1.
RefSeqiNP_446358.2. NM_053906.2.
UniGeneiRn.19721.

Genome annotation databases

EnsembliENSRNOT00000020252; ENSRNOP00000020252; ENSRNOG00000014915.
GeneIDi116686.
KEGGirno:116686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06088698 Genomic DNA. No translation available.
CH473970 Genomic DNA. Translation: EDM09143.1.
RefSeqiNP_446358.2. NM_053906.2.
UniGeneiRn.19721.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020252; ENSRNOP00000020252; ENSRNOG00000014915.
GeneIDi116686.
KEGGirno:116686.

Organism-specific databases

CTDi2936.
RGDi621747. Gsr.

Phylogenomic databases

GeneTreeiENSGT00390000007578.
KOiK00383.
OMAiSFDPMII.
OrthoDBiEOG7HHWS0.
TreeFamiTF105353.

Enzyme and pathway databases

ReactomeiREACT_304258. Synthesis and interconversion of nucleotide di- and triphosphates.
REACT_317923. Detoxification of Reactive Oxygen Species.
REACT_358301. TP53 Regulates Metabolic Genes.

Miscellaneous databases

NextBioi35576736.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01421. gluta_reduc_1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LRE1_RAT
AccessioniPrimary (citable) accession number: F1LRE1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: June 24, 2015
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.