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F1LR25

- F1LR25_RAT

UniProt

F1LR25 - F1LR25_RAT

Protein
Submitted name:

Hepatocyte nuclear factor 3-alpha

Gene

Foxa1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: Ensembl
    2. chromatin remodeling Source: Ensembl
    3. dorsal/ventral neural tube patterning Source: Ensembl
    4. epithelial cell maturation involved in prostate gland development Source: Ensembl
    5. epithelial-mesenchymal signaling involved in prostate gland development Source: Ensembl
    6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    7. glucose homeostasis Source: Ensembl
    8. hormone metabolic process Source: Ensembl
    9. lung epithelial cell differentiation Source: Ensembl
    10. negative regulation of epithelial to mesenchymal transition Source: Ensembl
    11. neuron fate specification Source: Ensembl
    12. positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
    13. positive regulation of mitotic cell cycle Source: Ensembl
    14. positive regulation of neuron differentiation Source: Ensembl
    15. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    16. positive regulation of smoothened signaling pathway Source: Ensembl
    17. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    18. prostate gland epithelium morphogenesis Source: Ensembl
    19. prostate gland stromal morphogenesis Source: Ensembl
    20. response to estradiol Source: Ensembl
    21. secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl

    Keywords - Ligandi

    DNA-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hepatocyte nuclear factor 3-alphaImported
    Gene namesi
    Name:Foxa1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi2807. Foxa1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Contains fork-head DNA-binding domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115483.
    OMAiMNTMNTY.
    OrthoDBiEOG7C8GHD.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR013638. Fork-head_N.
    IPR018533. Forkhead_box_C.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    PF08430. Fork_head_N. 1 hit.
    PF09354. HNF_C. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LR25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGTVKMEGH ESNDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM    50
    NTMTTSGNMT PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG 100
    VTAMGAALSP GGMGSMGAQP AASMNGLGPY AAAMNPCMSP MAYAPSNLGR 150
    SRAGGGGDAK TFKRSYPHAK PPYSYISLIT MAIQQAPSKM LTLSEIYQWI 200
    MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK GSYWTLHPDS 250
    GNMFENGCYL RRQKRFKCEK QPGAGGGSGG GGSKGVPENR KDPSGPVNPS 300
    AESPIHRGVH GKASQLEGAP APGPAASPQT LDHSGATATG GASELKSPAS 350
    SSAPPISSGP GAICTPLSPG TWAPHESQLH LKGDPHYSFN HPFSINNLMS 400
    SSEQQHKLDF KAYEQALQYS PYGATLPASL PLGSASVATR SPIEPSALEP 450
    AYYQGVYSRP VLNTS 465
    Length:465
    Mass (Da):48,678
    Last modified:April 3, 2013 - v2
    Checksum:iC97DAC21C725A7BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06044192 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000009940; ENSRNOP00000009940; ENSRNOG00000009284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06044192 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009940 ; ENSRNOP00000009940 ; ENSRNOG00000009284 .

    Organism-specific databases

    RGDi 2807. Foxa1.

    Phylogenomic databases

    GeneTreei ENSGT00740000115483.
    OMAi MNTMNTY.
    OrthoDBi EOG7C8GHD.

    Miscellaneous databases

    NextBioi 35576631.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR013638. Fork-head_N.
    IPR018533. Forkhead_box_C.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    PF08430. Fork_head_N. 1 hit.
    PF09354. HNF_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LR25_RAT
    AccessioniPrimary (citable) accession number: F1LR25
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 26 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3