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Protein
Submitted name:

MutS homolog 3

Gene

Msh3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5358606. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).

Names & Taxonomyi

Protein namesi
Submitted name:
MutS homolog 3Imported
Gene namesi
Name:Msh3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1563954. Msh3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1LQM8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013673.
GenevisibleiF1LQM8. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018449.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini927 – 943DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST17

Phylogenomic databases

eggNOGiKOG0217. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000074949.
InParanoidiF1LQM8.
OMAiYHLKSEF.
OrthoDBiEOG091G0JQY.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
InterProiView protein in InterPro
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR017261. DNA_mismatch_repair_MutS/MSH.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR036187. DNA_mismatch_repair_MutS_sf.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR036678. MutS_con_dom_sf.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PIRSFiPIRSF037677. DNA_mis_repair_Msh6. 1 hit.
SMARTiView protein in SMART
SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 2 hits.
SSF55271. SSF55271. 1 hit.
PROSITEiView protein in PROSITE
PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LQM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRKSASGG SNAAGPDPGR QVVLSRFFKS AGSLRSSVSP TEPAEKVTEG
60 70 80 90 100
DSRKRSLGNG EPTNKKAKKV PEEEGENTSV ASHNPEPKKC LRPRIVSKSL
110 120 130 140 150
EKLKEFCCDS ALPQNRVQTE ALWERLAVLP KCTDFEDITL QRAKNAVLSE
160 170 180 190 200
DSKSQANQKD TQFGPSPEAF QKTSTCKPFN RRSKSIYTPL ELQYLDVKQL
210 220 230 240 250
HKDAVLCVEC GYKYRFFGED AEIAARELNI YCHLDHNFMT ASIPTHRLFV
260 270 280 290 300
HVRRLVAKGY KVGVVKQTET AALKAIGDNK SSVFSRKLTA LYTKSTLIGE
310 320 330 340 350
DVNPLIRLDD SVNIDEAVTD TSTNYLLCIY EEKENIKDKK KGNISFGIVG
360 370 380 390 400
VQPATGEVVF DCFQDSASRL ELETRTASLQ PVELLLPSQL SEPTEMLIRR
410 420 430 440 450
ATAVSVGDDR IRVERMNNTH FEYSHAFQTV MEFYARETVD TQGSQSLSGV
460 470 480 490 500
IHLEKPVICA LAAIIRYLKE FNLDKVLSKP ENFKQLSSGM EFMRINGTTL
510 520 530 540 550
RNLEILQNQT DMKTRGSLLW VLDHTKTSFG RRKLKKWVTQ PLLKLRDINA
560 570 580 590 600
RLDAISDVLH SESSVFEQIE NLLRKLPDVE RGLCSIYHKK CSTQEFFLIV
610 620 630 640 650
KNLCQLKSEL QALMPAVNSH VQSDLLRARV LEVPELLSPV EPYLKVLNEQ
660 670 680 690 700
AAKAGDKTEL FKDLSDFPLI KKRKNEIQEV IHSIQMHLQE LRKILKLPSL
710 720 730 740 750
QYVTVSGQEF MVEIKNSAVS CVPTDWVKVG STKAVSRFHS PFVVENYRRL
760 770 780 790 800
NQLREQLVLD CNAEWLDFLE NFGEHYHTLC KAVDHLATVD CIFSLAKVAK
810 820 830 840 850
QGSYCRPTLQ EEKKIIIKNG RHPMIDVLLG EQDQFVPNST NLSDSERVMI
860 870 880 890 900
ITGPNMGGKS SYIKQVALVV IMAQIGSYVP AEEATIGIVD GIFTRRGAAD
910 920 930 940 950
NIYKGRSTFM EELTDTAEII QKATQRSLVI LDELGRGTST HDGIAIAYAT
960 970 980 990 1000
LEYFIRDVKS LTLFVTHYPP VCELEKRYPE QVGNYHMGFL VNEDGSKQDS
1010 1020 1030 1040 1050
GDMEQMPDSV TFLYQITRGI AARSYGLNVA KLADVPREIL QKAAHKSKEL
1060 1070 1080 1090 1100
EGLVNLRRKR LEYFIDLWTT HSVKDLHTRA AELEIQEIQT SPHNEMKTTL

LELK
Length:1,104
Mass (Da):124,618
Last modified:July 22, 2015 - v2
Checksum:i5BF774EFFBF9AF32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07007645 Genomic DNA. No translation available.
RefSeqiXP_006231830.1. XM_006231768.2.
UniGeneiRn.162551.

Genome annotation databases

EnsembliENSRNOT00000018449; ENSRNOP00000018449; ENSRNOG00000013673.
GeneIDi499505.

Similar proteinsi

Entry informationi

Entry nameiF1LQM8_RAT
AccessioniPrimary (citable) accession number: F1LQM8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: November 22, 2017
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported