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Protein
Submitted name:

Aggrecan core protein

Gene

Acan

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Aggrecan core proteinImported
Gene namesi
Name:AcanImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi68358 Acan

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500326571920 – 2121Sequence analysisAdd BLAST2102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi199 ↔ 220PROSITE-ProRule annotation
Disulfide bondi297 ↔ 318PROSITE-ProRule annotation
Disulfide bondi530 ↔ 551PROSITE-ProRule annotation
Disulfide bondi628 ↔ 649PROSITE-ProRule annotation
Disulfide bondi2038 ↔ 2081PROSITE-ProRule annotation
Disulfide bondi2067 ↔ 2094PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000028992
ExpressionAtlasiF1LQI4 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 147Ig-likeInterPro annotationAdd BLAST114
Domaini153 – 248LinkInterPro annotationAdd BLAST96
Domaini254 – 350LinkInterPro annotationAdd BLAST97
Domaini487 – 579LinkInterPro annotationAdd BLAST93
Domaini585 – 681LinkInterPro annotationAdd BLAST97
Domaini1918 – 2032C-type lectinInterPro annotationAdd BLAST115
Domaini2036 – 2096SushiInterPro annotationAdd BLAST61

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJP2 Eukaryota
ENOG410XRES LUCA
GeneTreeiENSGT00760000119025

Family and domain databases

CDDicd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit
Gene3Di2.60.40.101 hit
3.10.100.105 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 4 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 4 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 5 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 4 hits
PS50923 SUSHI, 1 hit

Sequencei

Sequence statusi: Complete.

F1LQI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLLLVFVT LRVIAAVISE EVPDHDNSLS VSIPQPSPLK ALLGTSLTIP
60 70 80 90 100
CYFIDPMHPV TTAPSTAPLT PRIKWSRVSK EKEVVLLVAT EGQVRVNSIY
110 120 130 140 150
QDKVSLPNYP AIPSDATLEI QNLRSNDSGI YRCEVMHGIE DSEATLEVIV
160 170 180 190 200
KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD
210 220 230 240 250
AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE
260 270 280 290 300
MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QGGMDMCSAG
310 320 330 340 350
WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT
360 370 380 390 400
GEDFVDIPEN FFGVGGEEDI TIQTVTWPDL ELPLPRNITE GEARGNVILT
410 420 430 440 450
AKPIFDMSPT VSEPGEALTL APEVGTTVFP EAGERTEKTT RPWGFPEEAT
460 470 480 490 500
RGPDSATAFA SEDLVVRVTI SPGAVEVPGQ PRLPGGVVFH YRPGSTRYSL
510 520 530 540 550
TFEEAQQACI RTGAAIASPE QLQAAGYEQC DAGWLXXXTV XYPIVSPRTP
560 570 580 590 600
CVGDKDSSPG VRTYGVRPSS ETYDVYCYVD KLEGEVFFAT QMEQFTFQEA
610 620 630 640 650
QAFCAAQNAT LASTGQLYAA WSQGLDKCYA GWLADGTLRY PIVNPRPACG
660 670 680 690 700
GDKPGVRTVY LYPNQTGLPD PLSKHHAFCF RGVSVAPSPG GTPTSPSDIE
710 720 730 740 750
DWIVTRVEPG VDAVPLEPET TEVPYFTTEP EKQTEWEPAY TPVGTSPLPG
760 770 780 790 800
IPPTWLPTVP AAEEHTESPS ASQEPSASQV PSTSEEPYTP SLAVPSGTEL
810 820 830 840 850
PSSGDTSGAP DLSGDFTGST DTSGRLDSSG EPSGGSESGL PSGDLDSSGL
860 870 880 890 900
GPTVSSGLPV ESGSASGDGE IPWSSTPTVG RLPSGGESLE GSASASGTGD
910 920 930 940 950
LSGLPSGGEI TETSASGTEE ISGLPSGGDD LETSTSGIDG ASVLPTGRGG
960 970 980 990 1000
LETSASGVED LSGLPSGEEG SETSTSGIED ISVLPTGESP ETSASGVGDL
1010 1020 1030 1040 1050
SGLPSGGESL ETSASGVEDV TQLPTERGGL ETSASGIEDI TVLPTGRENL
1060 1070 1080 1090 1100
ETSASGVEDV SGLPSGKEGL ETSASGIEDI SVFPTEAEGL ETSASGGYVS
1110 1120 1130 1140 1150
GIPSGEDGTE TSTSGVEGVS GLPSGGEGLE TSASGVEDLG LPTRDSLETS
1160 1170 1180 1190 1200
ASGVDVTGYP SGREDTETSV PGVGDDLSGL PSGQEGLETS ASGAEDLGGL
1210 1220 1230 1240 1250
PSGKEDLVGS ASGALDFGKL PSGTLGSGQT PEASGLPSGF SGEYSGVDIG
1260 1270 1280 1290 1300
SGPSSGLPDF SGLPSGFPTV SLVDSTLVEV ITATTASELE GRGTISVSGS
1310 1320 1330 1340 1350
GEESGPPLSE LDSSADISGL PSGTELSGQT SGSLDVSGET SGFFDVSGQP
1360 1370 1380 1390 1400
FGSSGTGEGT SGIPEVSGQP SGSPDTTEIS ELSGLSSGQP DVSGEGSGIL
1410 1420 1430 1440 1450
FGSGQSSGIT SVSGETSGIS DLSGQPSGFP VLSGTTPGTP DLASGAMSGS
1460 1470 1480 1490 1500
GDSSGITFVD TSLIEVTPTT FREEEGLGSV ELSGLPSGET DLSGTSGMVD
1510 1520 1530 1540 1550
VSGQSSGAID SSGLISPTPE FSGLPSGVAE VSGEVSGVET GSSLSSGAFD
1560 1570 1580 1590 1600
GSGLVSGFPT VSLVDRTLVE SITLAPTAQE AGEGPSSILE FSGAHSGTPD
1610 1620 1630 1640 1650
ISGDLSGSLD QSTWQPGWTE ASTEPPSSPY FSGDFSSTTD ASGESITAPT
1660 1670 1680 1690 1700
GSGETSGLPE VTLITSELVE GVTEPTVSQE LGHGPSMTYT PRLFEASGEA
1710 1720 1730 1740 1750
SASGDLGGPV TIFPGSGVEA SVPEGSSDPS AYPEAGVGVS AAPEASSQLS
1760 1770 1780 1790 1800
EFPDLHGITS ASRETDLEMT TPGTEVSSNP WTFQEGTREG SAAPEVSGES
1810 1820 1830 1840 1850
STTSDIDAGT SGVPFATPMT SGDRTEISGE WSDHTSEVNV TVSTTVPESR
1860 1870 1880 1890 1900
WAQSTQHPTE TLQEIGSPNP SYSGEETQTA ETAKSLTDTP TLASPEGSGE
1910 1920 1930 1940 1950
TESTAADQEQ CEEGWTKFQG HCYRHFPDRE TWVDAERRCR EQQSHLSSIV
1960 1970 1980 1990 2000
TPEEQEFVNK NAQDYQWIGL NDRTIEGDFR WSDGHSLQFE KWRPNQPDNF
2010 2020 2030 2040 2050
FATGEDCVVM IWHERGEWND VPCNYQLPFT CKKGTVACGE PPAVEHARTL
2060 2070 2080 2090 2100
GQKKDRYEIS SLVRYQCTEG FVQRHVPTIR CQPSGHWEEP RITCTDPNTY
2110 2120
KHRLQKRSMR PTRRSRPSMA H
Length:2,121
Mass (Da):220,565
Last modified:April 3, 2013 - v2
Checksum:i6DDD5BB2F6644FC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07004393 Genomic DNA No translation available.
AABR07071921 Genomic DNA No translation available.
AC106909 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000049681; ENSRNOP00000044130; ENSRNOG00000028992

Similar proteinsi

Entry informationi

Entry nameiF1LQI4_RAT
AccessioniPrimary (citable) accession number: F1LQI4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: April 25, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported