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Protein
Submitted name:

Nuclear factor NF-kappa-B p105 subunit

Gene

Nfkb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-1810476. RIP-mediated NFkB activation via ZBP1.
R-RNO-193692. Regulated proteolysis of p75NTR.
R-RNO-202424. Downstream TCR signaling.
R-RNO-209560. NF-kB is activated and signals survival.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-448706. Interleukin-1 processing.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-5621575. CD209 (DC-SIGN) signaling.
R-RNO-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-RNO-933542. TRAF6 mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor NF-kappa-B p105 subunitImported
Gene namesi
Name:Nfkb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi70498. Nfkb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiF1LQH2.

PTM databases

PhosphoSiteiF1LQH2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023258.
GenevisibleiF1LQH2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028944.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 245208RHD (Rel-like)InterPro annotationAdd
BLAST
Domaini540 – 748209ANK_REP_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation
Contains 4 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00500000044765.
OMAiHEQMFHL.
OrthoDBiEOG091G03PF.
TreeFamiTF325632.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR030503. NF-kB_p105.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030492. RHD_CS.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 2 hits.
PTHR24169:SF9. PTHR24169:SF9. 2 hits.
PfamiPF12796. Ank_2. 2 hits.
PF00531. Death. 1 hit.
PF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR00057. NFKBTNSCPFCT.
SMARTiSM00248. ANK. 6 hits.
SM00005. DEATH. 1 hit.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LQH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDDPFGTG QMFHLNTALT HSIFNAELYS TDIPLSTADG PYLQILEQPK
60 70 80 90 100
QRGFRFRYVC EGPSHGGLPG ASSEKNKKSY PQVKICNYVG PAKVIVQLVT
110 120 130 140 150
NGKNIHLHAH SLVGKHCEDG ICTVTAGPKD MVVGFANLGI LHVTKKKVFE
160 170 180 190 200
TLEARMTEAC IRGYNPGLLV HSDLAYLQAE GGGDRQLTDR EKEIIRQAAL
210 220 230 240 250
QQTKEMDLSV VRLMFTAFLP DSTGSFTRRL EPVVSDAIYD SKAPNASNLK
260 270 280 290 300
IVRMDRTAGC VTGGEEIYLL CDKVQKDDIQ IRFYEEEENG GVWEGFGDFS
310 320 330 340 350
PTDVHRQFAI VFKTPKYKDV NITKPASVFV QLRRKSDLET SEPKPFLYYP
360 370 380 390 400
EIKDKEEVQR KRQKLMPNFS DSFGGGSGAG AGGGGMFGSG GGGGGSTGSP
410 420 430 440 450
GPGYGFPHYG FPAYGGIAFH PGATKSNTGI THGTINTKFK NEPRDCAKSD
460 470 480 490 500
DREILNPPEK ETQGEGPSLF MASTKTEAIA PASTMEDKEE DVGFQDNLFL
510 520 530 540 550
EKALQLAKRH ANALFDYAVT GDVKMLLAVQ RHLTAVQDEN GDSVLHLAII
560 570 580 590 600
HLHAQLVRDL LEVTSGSISD DIINMRNDLY QTPLHLAVIT KQEDVVEDLL
610 620 630 640 650
RVGADLSLLD RWGNSVLHLA AKEGHDKILG VLLKNSKAAL LINHPNGEGL
660 670 680 690 700
NAIHIAVMSN SLSCLQLLVA AGAEVNAQEQ KSGRTALHLA VEYDNISLAG
710 720 730 740 750
CLLLEGDALV DSTTYDGTTP LHIAAGRGST RLAALLKAAG ADPLVENFEP
760 770 780 790 800
LYDLDDSWEK AGEDEGVVPG TTPLDMAANW QVFDILNGKP YEPVFTSDDI
810 820 830 840 850
LPQGDIKQLT EDTRLQLCKL LEIPDPDKNW ATLAQKLGLG ILNNAFRLSP
860 870 880 890 900
APSKTLMDNY EVSGGTIKEL VEALRQMGYT EAIEVIQAAF RTPETTASSP
910 920 930 940 950
VTTAQAHLLP LSSSSTRQHI DELRDNDSVC DSGVETSFRK LSFSESLTGD
960 970
GPLLSLNKMP HNYGQDGPIE GKI
Length:973
Mass (Da):105,704
Last modified:July 22, 2015 - v2
Checksum:iD88ECEA20A389AB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07013507 Genomic DNA. No translation available.
AABR07013508 Genomic DNA. No translation available.
AABR07072788 Genomic DNA. No translation available.
RefSeqiXP_006233420.1. XM_006233358.2.
UniGeneiRn.2411.

Genome annotation databases

EnsembliENSRNOT00000036838; ENSRNOP00000028944; ENSRNOG00000023258.
GeneIDi81736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07013507 Genomic DNA. No translation available.
AABR07013508 Genomic DNA. No translation available.
AABR07072788 Genomic DNA. No translation available.
RefSeqiXP_006233420.1. XM_006233358.2.
UniGeneiRn.2411.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028944.

PTM databases

PhosphoSiteiF1LQH2.

Proteomic databases

PaxDbiF1LQH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036838; ENSRNOP00000028944; ENSRNOG00000023258.
GeneIDi81736.

Organism-specific databases

CTDi4790.
RGDi70498. Nfkb1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00500000044765.
OMAiHEQMFHL.
OrthoDBiEOG091G03PF.
TreeFamiTF325632.

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-1810476. RIP-mediated NFkB activation via ZBP1.
R-RNO-193692. Regulated proteolysis of p75NTR.
R-RNO-202424. Downstream TCR signaling.
R-RNO-209560. NF-kB is activated and signals survival.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-448706. Interleukin-1 processing.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-5621575. CD209 (DC-SIGN) signaling.
R-RNO-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-RNO-933542. TRAF6 mediated NF-kB activation.

Gene expression databases

BgeeiENSRNOG00000023258.
GenevisibleiF1LQH2. RN.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR030503. NF-kB_p105.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030492. RHD_CS.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 2 hits.
PTHR24169:SF9. PTHR24169:SF9. 2 hits.
PfamiPF12796. Ank_2. 2 hits.
PF00531. Death. 1 hit.
PF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR00057. NFKBTNSCPFCT.
SMARTiSM00248. ANK. 6 hits.
SM00005. DEATH. 1 hit.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1LQH2_RAT
AccessioniPrimary (citable) accession number: F1LQH2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 7, 2016
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.