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F1LQH2

- F1LQH2_RAT

UniProt

F1LQH2 - F1LQH2_RAT

Protein
Submitted name:

Nuclear factor NF-kappa-B p105 subunit

Gene

Nfkb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. cellular response to interleukin-1 Source: Ensembl
    2. cellular response to mechanical stimulus Source: Ensembl
    3. negative regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    4. negative regulation of cytokine production Source: Ensembl
    5. negative regulation of inflammatory response Source: Ensembl
    6. negative regulation of interleukin-12 biosynthetic process Source: Ensembl
    7. negative regulation of transcription, DNA-templated Source: Ensembl
    8. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    9. positive regulation of hyaluronan biosynthetic process Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nuclear factor NF-kappa-B p105 subunitImported
    Gene namesi
    Name:Nfkb1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi70498. Nfkb1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Expressioni

    Gene expression databases

    ArrayExpressiF1LQH2.

    Structurei

    3D structure databases

    ProteinModelPortaliF1LQH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RHD (Rel-like) domain.UniRule annotation
    Contains 6 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, RepeatUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00500000044765.
    KOiK02580.
    OMAiPGYGFPH.
    OrthoDBiEOG7W154S.
    TreeFamiTF325632.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    1.25.40.20. 1 hit.
    2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF00531. Death. 1 hit.
    PF00554. RHD. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    PR00057. NFKBTNSCPFCT.
    SMARTiSM00248. ANK. 6 hits.
    SM00005. DEATH. 1 hit.
    SM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LQH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADDDPFGTG QMFHLNTALT HSIFNAELYS TDIPLSTDGP YLQILEQPKQ    50
    RGFRFRYVCE GPSHGGLPGA SSEKNKKSYP QVKICNYVGP AKVIVQLVTN 100
    GKNIHLHAHS LVGKHCEDGI CTVTAGPKDM VVGFANLGIL HVTKKKVFET 150
    LEARMTEACI RGYNPGLLVH SDLAYLQAEG GGDRQLTDRE KEIIRQAALQ 200
    QTKEMDLSVV RLMFTAFLPD STGSFTRRLE PVVSDAIYDS KAPNASNLKI 250
    VRMDRTAGCV TGGEEIYLLC DKVQKDDIQI RFYEEEENGG VWEGFGDFSP 300
    TDVHRQFAIV FKTPKYKDVN ITKPASVFVQ LRRKSDLETS EPKPFLYYPE 350
    IKDKEEVQRK RQKLMPNFSD SFGGGSGAGA GGGGMFGSGG GGGGSTGSPG 400
    PGYGFPHYGF PAYGGIAFHP GATKSNTGIT HGTINTKFKN EPRDCAKSDD 450
    REILNPPEKE TQGEGPSLFM ASTKTEAIAP ASTMEDKEED VGFQDNLFLE 500
    KALQLAKRHA NALFDYAVTG DVKMLLAVQR HLTAVQDENG DSVLHLAIIH 550
    LHAQLVRDLL EVTSGSISDD IINMRNDLYQ TPLHLAVITK QEDVVEDLLR 600
    VGADLSLLDR WGNSVLHLAA KEGHDKILGV LLKNSKAALL INHPNGEGLN 650
    AIHIAVMSNS LSCLQLLVAA GAEVNAQEQK SGRTALHLAV EYDNISLAGC 700
    LLLEGDALVD STTYDGTTPL HIAAGRGSTR LAALLKAAGA DPLVENFEPL 750
    YDLDDSWEKA GEDEGVVPGT TPLDMAANWQ VFDILNGKPY EPVFTSDDIL 800
    PQGDIKQLTE DTRLQLCKLL EIPDPDKNWA TLAQKLGLGI LNNAFRLSPA 850
    PSKTLMDNYE VSGGTIKELV EALRQMGYTE AIEVIQAAFR TPETTASSPV 900
    TTAQAHLLPL SSSSTRQHID ELRDNDSVCD SGVETSFRKL SFSESLTGDG 950
    PLLSLNKMPH NYGQDGPIEG KI 972
    Length:972
    Mass (Da):105,633
    Last modified:May 3, 2011 - v1
    Checksum:i892B84AF39134462
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06020892 Genomic DNA. No translation available.
    AABR06020893 Genomic DNA. No translation available.
    AABR06020894 Genomic DNA. No translation available.
    AABR06020895 Genomic DNA. No translation available.
    AABR06020896 Genomic DNA. No translation available.
    RefSeqiNP_001263640.1. NM_001276711.1.
    XP_006233421.1. XM_006233359.1.
    UniGeneiRn.2411.

    Genome annotation databases

    EnsembliENSRNOT00000036838; ENSRNOP00000028944; ENSRNOG00000023258.
    GeneIDi81736.
    KEGGirno:81736.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06020892 Genomic DNA. No translation available.
    AABR06020893 Genomic DNA. No translation available.
    AABR06020894 Genomic DNA. No translation available.
    AABR06020895 Genomic DNA. No translation available.
    AABR06020896 Genomic DNA. No translation available.
    RefSeqi NP_001263640.1. NM_001276711.1.
    XP_006233421.1. XM_006233359.1.
    UniGenei Rn.2411.

    3D structure databases

    ProteinModelPortali F1LQH2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000036838 ; ENSRNOP00000028944 ; ENSRNOG00000023258 .
    GeneIDi 81736.
    KEGGi rno:81736.

    Organism-specific databases

    CTDi 4790.
    RGDi 70498. Nfkb1.

    Phylogenomic databases

    GeneTreei ENSGT00500000044765.
    KOi K02580.
    OMAi PGYGFPH.
    OrthoDBi EOG7W154S.
    TreeFami TF325632.

    Miscellaneous databases

    NextBioi 615420.
    PROi F1LQH2.

    Gene expression databases

    ArrayExpressi F1LQH2.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    1.25.40.20. 1 hit.
    2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF00531. Death. 1 hit.
    PF00554. RHD. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    PR00057. NFKBTNSCPFCT.
    SMARTi SM00248. ANK. 6 hits.
    SM00005. DEATH. 1 hit.
    SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LQH2_RAT
    AccessioniPrimary (citable) accession number: F1LQH2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3