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Protein
Submitted name:

Neuroligin 3, isoform CRA_a

Gene

Nlgn3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6794361. Neurexins and neuroligins.

Protein family/group databases

ESTHERiratno-3neur. Neuroligin.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroligin 3, isoform CRA_aImported
Submitted name:
Neuroligin-3Imported
Gene namesi
Name:Nlgn3Imported
ORF Names:rCG_36364Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621119. Nlgn3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei708 – 731HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_501120584538 – 848Sequence analysisAdd BLAST811

Expressioni

Gene expression databases

BgeeiENSRNOG00000003812.
ExpressionAtlasiF1LPZ8. baseline.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 624COesteraseInterPro annotationAdd BLAST584

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
KOiK07378.
OMAiNAVPEIM.
OrthoDBiEOG091G0CHW.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030024. NLGN3.
PANTHERiPTHR43903:SF4. PTHR43903:SF4. 1 hit.
PfamiView protein in Pfam
PF00135. COesterase. 1 hit.
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiView protein in PROSITE
PS00941. CARBOXYLESTERASE_B_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LPZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLQLGLPSL SLSPTPTVGR SLCLILWFLS LVLRASTQAP APTVNTHFGK
60 70 80 90 100
LRGARVPLPS EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT
110 120 130 140 150
HFPPVCPQNI HTAVPEVMLP VWFTANLDIV ATYIQEPNED CLYLNVYVPT
160 170 180 190 200
EDVKRISKEC ARKPNKKICR KGGSGAKKQG EDLADNDGDE DEDIRDSGAK
210 220 230 240 250
PVMVYIHGGS YMEGTGNMID GSVLASYGNV IVITLNYRVG VLGFLSTGDQ
260 270 280 290 300
AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS
310 320 330 340 350
HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD
360 370 380 390 400
CLRQKSAKEL VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD
410 420 430 440 450
IMLGVNQGEG LKFVEGVVDP EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL
460 470 480 490 500
RETIKFMYTD WADRDNPETR RKTLVALFTD HQWVEPSVVT ADLHARYGSP
510 520 530 540 550
TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD LFPCNFSKND
560 570 580 590 600
VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD
610 620 630 640 650
QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP
660 670 680 690 700
DTTHSSHITR RPNGKTWSTK RPAISPAYSN ENAPGSWNGD QDAGPLLVEN
710 720 730 740 750
PRDYSTELSV TIAVGASLLF LNVLAFAALY YRKDKRRQEP LRQPSPQRGT
760 770 780 790 800
GAPELGTAPE EELAALQLGP THHECEAGPP HDTLRLTALP DYTLTLRRSP
810 820 830 840
DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP HSHSTTRV
Length:848
Mass (Da):93,911
Last modified:April 3, 2013 - v2
Checksum:i9B20653B3253E755
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07039195 Genomic DNA. No translation available.
CH473966 Genomic DNA. Translation: EDL95899.1.
RefSeqiNP_599163.2. NM_134336.2.
XP_008771473.1. XM_008773251.2.
UniGeneiRn.226139.

Genome annotation databases

EnsembliENSRNOT00000005077; ENSRNOP00000005077; ENSRNOG00000003812.
GeneIDi171297.
KEGGirno:171297.

Similar proteinsi

Entry informationi

Entry nameiF1LPZ8_RAT
AccessioniPrimary (citable) accession number: F1LPZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: December 20, 2017
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported