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F1LPV2

- F1LPV2_RAT

UniProt

F1LPV2 - F1LPV2_RAT

Protein
Submitted name:

Very low-density lipoprotein receptor

Gene

Vldlr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. glycoprotein transporter activity Source: Ensembl
    3. reelin receptor activity Source: Ensembl
    4. very-low-density lipoprotein particle binding Source: Ensembl
    5. very-low-density lipoprotein particle receptor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. positive regulation of dendrite development Source: Ensembl
    3. positive regulation of protein kinase activity Source: Ensembl
    4. ventral spinal cord development Source: Ensembl
    5. very-low-density lipoprotein particle clearance Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Very low-density lipoprotein receptorImported
    Gene namesi
    Name:VldlrImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3963. Vldlr.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114992.
    OMAiMGTSARW.
    OrthoDBiEOG7NGQ9P.
    TreeFamiTF351700.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    4.10.400.10. 8 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view]
    PfamiPF07645. EGF_CA. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF00058. Ldl_recept_b. 5 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 2 hits.
    SM00192. LDLa. 8 hits.
    SM00135. LY. 5 hits.
    [Graphical view]
    SUPFAMiSSF57424. SSF57424. 8 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 8 hits.
    PS51120. LDLRB. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LPV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTSARWALW LLLALCWAPR DSGATASGKK AKCDSSQFQC TNGRCITLLW    50
    KCDGDEDCTD GSDEKNCVKK TCAESDFVCK NGQCVPNRWQ CDGDPDCEDG 100
    SDESPEQCHM RTCRINEISC GARSTQCIPE SWRCDGENDC DNGEDEENCG 150
    NITCSADEFT CSSGRCVSRN FVCNGQDDCD DGSDELDCAP PTCGAHEFQC 200
    STSSCIPLSW VCDDDADCSD QSDESLEQCG RQPVIHTKCP TSEIQCGSGE 250
    CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI 300
    RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDITKVCDQ EQDCRDWSDE 350
    PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC 400
    QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD 450
    IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD 500
    KVGRHFKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGTKRKFL 550
    FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTEDIQ 600
    WPNGITLDLV KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL 650
    TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIIYHELVQP 700
    SGKNWCEEDM ENGGCEYLCL PAPQINDHSP KYTCSCPNGY NLEENGRECQ 750
    STSTPVTYSE TKDVNTTDIL RTSGLVPGGI NVTTAVSEVS VPPKGTSAAW 800
    AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG 850
    RHSASVGHTY PAISVVSTDD DLA 873
    Length:873
    Mass (Da):96,473
    Last modified:May 3, 2011 - v1
    Checksum:i6E70D1E0CE12C291
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010435 Genomic DNA. No translation available.
    RefSeqiNP_037287.2. NM_013155.2.
    XP_006231259.1. XM_006231197.1.
    XP_006231260.1. XM_006231198.1.
    UniGeneiRn.9975.

    Genome annotation databases

    EnsembliENSRNOT00000035814; ENSRNOP00000036229; ENSRNOG00000027491.
    GeneIDi25696.
    KEGGirno:25696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010435 Genomic DNA. No translation available.
    RefSeqi NP_037287.2. NM_013155.2.
    XP_006231259.1. XM_006231197.1.
    XP_006231260.1. XM_006231198.1.
    UniGenei Rn.9975.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000035814 ; ENSRNOP00000036229 ; ENSRNOG00000027491 .
    GeneIDi 25696.
    KEGGi rno:25696.

    Organism-specific databases

    CTDi 7436.
    RGDi 3963. Vldlr.

    Phylogenomic databases

    GeneTreei ENSGT00740000114992.
    OMAi MGTSARW.
    OrthoDBi EOG7NGQ9P.
    TreeFami TF351700.

    Miscellaneous databases

    NextBioi 607711.
    PROi F1LPV2.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    4.10.400.10. 8 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF00058. Ldl_recept_b. 5 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 2 hits.
    SM00192. LDLa. 8 hits.
    SM00135. LY. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57424. SSF57424. 8 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 8 hits.
    PS51120. LDLRB. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LPV2_RAT
    AccessioniPrimary (citable) accession number: F1LPV2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3