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Protein
Submitted name:

Very low-density lipoprotein receptor

Gene

Vldlr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-8855121. VLDL interactions.
R-RNO-8866376. Reelin signalling pathway.
R-RNO-8866427. VLDLR internalisation and degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Very low-density lipoprotein receptorImported
Gene namesi
Name:VldlrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3963. Vldlr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei798 – 819HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500326601924 – 873Sequence analysisAdd BLAST850

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1LPV2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000027491.
GenevisibleiF1LPV2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036229.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 395EGF-likeInterPro annotationAdd BLAST40
Domaini396 – 431EGF-likeInterPro annotationAdd BLAST36

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPT5. Eukaryota.
ENOG410YQ6J. LUCA.
GeneTreeiENSGT00760000118968.
KOiK20053.
OMAiDEHTANC.
OrthoDBiEOG091G01MX.
TreeFamiTF351700.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 8 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR032931. VLDLR.
[Graphical view]
PANTHERiPTHR10529:SF101. PTHR10529:SF101. 1 hit.
PfamiPF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 2 hits.
SM00192. LDLa. 8 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 8 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LPV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSARWALW LLLALCWAPR DSGATASGKK AKCDSSQFQC TNGRCITLLW
60 70 80 90 100
KCDGDEDCTD GSDEKNCVKK TCAESDFVCK NGQCVPNRWQ CDGDPDCEDG
110 120 130 140 150
SDESPEQCHM RTCRINEISC GARSTQCIPE SWRCDGENDC DNGEDEENCG
160 170 180 190 200
NITCSADEFT CSSGRCVSRN FVCNGQDDCD DGSDELDCAP PTCGAHEFQC
210 220 230 240 250
STSSCIPLSW VCDDDADCSD QSDESLEQCG RQPVIHTKCP TSEIQCGSGE
260 270 280 290 300
CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI
310 320 330 340 350
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDITKVCDQ EQDCRDWSDE
360 370 380 390 400
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC
410 420 430 440 450
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD
460 470 480 490 500
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD
510 520 530 540 550
KVGRHFKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGTKRKFL
560 570 580 590 600
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTEDIQ
610 620 630 640 650
WPNGITLDLV KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL
660 670 680 690 700
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIIYHELVQP
710 720 730 740 750
SGKNWCEEDM ENGGCEYLCL PAPQINDHSP KYTCSCPNGY NLEENGRECQ
760 770 780 790 800
STSTPVTYSE TKDVNTTDIL RTSGLVPGGI NVTTAVSEVS VPPKGTSAAW
810 820 830 840 850
AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG
860 870
RHSASVGHTY PAISVVSTDD DLA
Length:873
Mass (Da):96,473
Last modified:May 3, 2011 - v1
Checksum:i6E70D1E0CE12C291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006664 Genomic DNA. No translation available.
RefSeqiNP_037287.2. NM_013155.2.
XP_006231259.1. XM_006231197.2.
XP_006231260.1. XM_006231198.3.
UniGeneiRn.9975.

Genome annotation databases

EnsembliENSRNOT00000035814; ENSRNOP00000036229; ENSRNOG00000027491.
GeneIDi25696.
KEGGirno:25696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006664 Genomic DNA. No translation available.
RefSeqiNP_037287.2. NM_013155.2.
XP_006231259.1. XM_006231197.2.
XP_006231260.1. XM_006231198.3.
UniGeneiRn.9975.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036229.

Proteomic databases

PaxDbiF1LPV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035814; ENSRNOP00000036229; ENSRNOG00000027491.
GeneIDi25696.
KEGGirno:25696.

Organism-specific databases

CTDi7436.
RGDi3963. Vldlr.

Phylogenomic databases

eggNOGiENOG410IPT5. Eukaryota.
ENOG410YQ6J. LUCA.
GeneTreeiENSGT00760000118968.
KOiK20053.
OMAiDEHTANC.
OrthoDBiEOG091G01MX.
TreeFamiTF351700.

Enzyme and pathway databases

ReactomeiR-RNO-8855121. VLDL interactions.
R-RNO-8866376. Reelin signalling pathway.
R-RNO-8866427. VLDLR internalisation and degradation.

Gene expression databases

BgeeiENSRNOG00000027491.
GenevisibleiF1LPV2. RN.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 8 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR032931. VLDLR.
[Graphical view]
PANTHERiPTHR10529:SF101. PTHR10529:SF101. 1 hit.
PfamiPF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 2 hits.
SM00192. LDLa. 8 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 8 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 8 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1LPV2_RAT
AccessioniPrimary (citable) accession number: F1LPV2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 2, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.