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Protein

Dual specificity protein phosphatase

Gene

Dusp5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei263Phosphocysteine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-112409. RAF-independent MAPK1/3 activation.
R-RNO-5675221. Negative regulation of MAPK pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation, EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Dusp5Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620854. Dusp5.

PTM / Processingi

Proteomic databases

PaxDbiF1LPJ5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014061.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 141RhodaneseInterPro annotationAdd BLAST123
Domaini178 – 318Tyrosine-protein phosphataseInterPro annotationAdd BLAST141
Domaini240 – 297TYR_PHOSPHATASE_2InterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
OMAiCVREKGG.
OrthoDBiEOG091G0249.
TreeFamiTF105122.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR036873. Rhodanese-like_dom_sf.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00450. RHOD. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiView protein in PROSITE
PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LPJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTSLDGRR LRKMLRKEAE ARCVVLDCRP YLAFAASSVR GSLNVNLNSV
60 70 80 90 100
VLRRARGGAV SARYVLPDEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR
110 120 130 140 150
EESAARVVLT SLLACLPAGP RVYFLKGGYE TFYSQYPECC VDAKPISQEK
160 170 180 190 200
LEGERGLLSQ CGKPILSVAY RPAYDQGGPV EILPFLYLGS AYHASKCEFL
210 220 230 240 250
ANLHITALLN VSRRTSEACT THLHYKWIPV EDSHTADISS HFQEAIDFID
260 270 280 290 300
CVREEGGKVL VHCEAGVSRS PTICMAYLMK TKQFRLKEAF EYIKQRRSVV
310 320 330 340 350
SPNFGFMGQL LQYESEILPS TPTPQPPSCQ GEAASSTFIG HLQTLSPDMQ
360 370 380
GAYCTFPTSV LAPVPTHATV AELHRSPVAT ATSC
Length:384
Mass (Da):42,130
Last modified:May 3, 2011 - v1
Checksum:iBD32004E7DA93314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115255 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000018889; ENSRNOP00000018889; ENSRNOG00000014061.

Similar proteinsi

Entry informationi

Entry nameiF1LPJ5_RAT
AccessioniPrimary (citable) accession number: F1LPJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 25, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported