ID   F1LP76_RAT              Unreviewed;      1331 AA.
AC   F1LP76;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Elongator complex protein 1 {ECO:0000256|ARBA:ARBA00029535, ECO:0000256|PIRNR:PIRNR017233};
GN   Name=Elp1 {ECO:0000313|Ensembl:ENSRNOP00000022836.5,
GN   ECO:0000313|RGD:620072}; Synonyms=Ikbkap {ECO:0000313|RGD:620072};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000022836.5, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000022836.5, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022836.5,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000022836.5}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022836.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine). The elongator complex catalyzes formation
CC       of carboxymethyluridine in the wobble base at position 34 in tRNAs.
CC       {ECO:0000256|PIRNR:PIRNR017233}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00005043}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR017233}.
CC       Nucleus {ECO:0000256|PIRNR:PIRNR017233}.
CC   -!- SIMILARITY: Belongs to the ELP1/IKA1 family.
CC       {ECO:0000256|ARBA:ARBA00006086, ECO:0000256|PIRNR:PIRNR017233}.
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DR   SMR; F1LP76; -.
DR   Ensembl; ENSRNOT00000022836.6; ENSRNOP00000022836.5; ENSRNOG00000016725.6.
DR   RGD; 620072; Elp1.
DR   GeneTree; ENSGT00390000013344; -.
DR   HOGENOM; CLU_001477_1_0_1; -.
DR   OMA; WRESLYC; -.
DR   TreeFam; TF300402; -.
DR   UniPathway; UPA00988; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000016725; Expressed in skeletal muscle tissue and 19 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0033588; C:elongator holoenzyme complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:Ensembl.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR006849; Elp1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12747; ELONGATOR COMPLEX PROTEIN 1; 1.
DR   PANTHER; PTHR12747:SF0; ELONGATOR COMPLEX PROTEIN 1; 1.
DR   Pfam; PF04762; IKI3; 1.
DR   PIRSF; PIRSF017233; IKAP; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR017233};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR017233};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ   SEQUENCE   1331 AA;  149199 MW;  FEA210441C537C69 CRC64;
     MRNLKLHQTL EFRDIQAPGK PQCFCLRAEQ GTVLIGSERG LTEVDPVKKE VKTEISLVAE
     GFLPEDGSGC IVGIQDLLDQ ESVCVATASG DVIVCNVSTQ QLECVGNVAS GISVMSWSPD
     QELLLLATAQ QTLIMMTRDY EVITEQQIHQ DDFGEGKFIT VGWGSKDTQF HGSEGRPITF
     PVQMHESALS WDDHRPQITW RGDGQFFAVS VVCSQTGARK IRVWNREFAL QSTSESVPGL
     GPSLAWKPSG SLIASTQDKP NQQDVVFFEK NGLLHGYFTL PFLKDEVKVN DLLWNADSSV
     LAVWLEDLPK EGSSTLKSYV QLWTVGNYHW YLKQSLPFST TGKNQIVSLL WDPVTPGRLH
     VLCQGWRYLC CDWHWTTDRS SGNSADDLAN VAVIDGNKVL VTVFQRTVTP PPMCTYRLLI
     PHPVNQVMFS AHLGNDLAVL DASNQISVYK CDDKPDMDST VKLGAVGGTG FKVPLRTPHL
     EKRYRIQFGN KEEEEDVSPL QFRFLTWIEG DAFLAISHSH SSPQSIIHHL TMAGSEGDEE
     QGQLNVSSSV TVDGVVIGLC CCSKTKSSAV QLADGQVLKY LWESPSSAVE PWKNSEGRPV
     RFARPCTQME AAAIGGEECV LGLTDRCRFF INDTEVASNI TSFAVCDDFL LVTTHSHTCQ
     CFSLSGASLK MLQAGLCGSQ VPSGEILRKV ERGSRIVTVV PQDTKLILQM PRGNLEVVHH
     RALVLAQIRK WLDKLMFKEA FECMRKLRIN LNLIHDHNPK VFLENVETFI KQIDSVNHLN
     LFFTELKEED VTKTMYPPPV TKSVQVSTNP DGKKVDLICD AMRVAMETIN PRKFCLSILT
     SHVKKTTPEL DIVLQKVHEL QGKIPFEPES VSAEEALKYL LLLVDVNELF NHSLGTYDFD
     LVLMVAEKSQ KDPKEYLPFL NTLKKMETNY QRFTIDKYLK RYEKALGHLS KCGPEYFTEC
     LNLIKDKNLY KEALKLYRPD SPQYQAVSVA YGEHLVQEHL YEPAGLVFAR CGAHEKALEA
     FLACGSWQQA LCMAAQLQMA KDKVAGLART LAGKLVEQRK HSEAATVLEQ YAQDYEEAVL
     LLLEGSAWEE ALRLVYKYDR VDIIETSVKP SILEAQKNYM DFLDSQTATF IRHKNRLKVV
     RELKSQAPRV HVDHEVAHGR ETDLFSETSS IRSGSEMSGR YSHSNSRISA RSSKNRRKAE
     RKKHSLKEGS PLEGLALLEA LSEVVQSIEK LKDEVHAILK VLFLFEFEEQ ARELQRAFES
     TLQLMGTALP DIWTLTGQQS SATPVLGPSS TVNSIMASYQ QQKTCVPVLD AWACLPPKID
     QRSQWKLSLL E
//