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Protein

Elongator complex protein 1

Gene

Ikbkap

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 1UniRule annotation
Gene namesi
Name:IkbkapImported
ORF Names:rCG_31928Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620072. Ikbkap.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiF1LP76.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016725.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022836.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP1/IKA1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1920. Eukaryota.
COG5290. LUCA.
GeneTreeiENSGT00390000013344.
OMAiCIASWDA.
OrthoDBiEOG091G01A5.
TreeFamiTF300402.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR006849. Iki3.
[Graphical view]
PANTHERiPTHR12747. PTHR12747. 1 hit.
PfamiPF04762. IKI3. 1 hit.
[Graphical view]
PIRSFiPIRSF017233. IKAP. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LP76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLKLHQTL EFRDIQAPGK PQCFCLRAEQ GTVLIGSERG LTEVDPVKKE
60 70 80 90 100
VKTEISLVAE GFLPEDGSGC IVGIQDLLDQ ESVCVATASG DVIVCNVSTQ
110 120 130 140 150
QLECVGNVAS GISVMSWSPD QELLLLATAQ QTLIMMTRDY EVITEQQIHQ
160 170 180 190 200
DDFGEGKFIT VGWGSKDTQF HGSEGRPITF PVQMHESALS WDDHRPQITW
210 220 230 240 250
RGDGQFFAVS VVCSQTGARK IRVWNREFAL QSTSESVPGL GPSLAWKPSG
260 270 280 290 300
SLIASTQDKP NQQDVVFFEK NGLLHGYFTL PFLKDEVKVN DLLWNADSSV
310 320 330 340 350
LAVWLEDLPK EGSSTLKSYV QLWTVGNYHW YLKQSLPFST TGKNQIVSLL
360 370 380 390 400
WDPVTPGRLH VLCQGWRYLC CDWHWTTDRS SGNSADDLAN VAVIDGNKVL
410 420 430 440 450
VTVFQRTVTP PPMCTYRLLI PHPVNQVMFS AHLGNDLAVL DASNQISVYK
460 470 480 490 500
CDDKPDMDST VKLGAVGGTG FKVPLRTPHL EKRYRIQFGN KEEEEDVSPL
510 520 530 540 550
QFRFLTWIEG DAFLAISHSH SSPQSIIHHL TMAGSEGDEE QGQLNVSSSV
560 570 580 590 600
TVDGVVIGLC CCSKTKSSAV QLADGQVLKY LWESPSSAVE PWKNSEGRPV
610 620 630 640 650
RFARPCTQME AAAIGGEECV LGLTDRCRFF INDTEVASNI TSFAVCDDFL
660 670 680 690 700
LVTTHSHTCQ CFSLSGASLK MLQAGLCGSQ VPSGEILRKV ERGSRIVTVV
710 720 730 740 750
PQDTKLILQM PRGNLEVVHH RALVLAQIRK WLDKLMFKEA FECMRKLRIN
760 770 780 790 800
LNLIHDHNPK VFLENVETFI KQIDSVNHLN LFFTELKEED VTKTMYPPPV
810 820 830 840 850
TKSVQVSTNP DGKKVDLICD AMRVAMETIN PRKFCLSILT SHVKKTTPEL
860 870 880 890 900
DIVLQKVHEL QGKIPFEPES VSAEEALKYL LLLVDVNELF NHSLGTYDFD
910 920 930 940 950
LVLMVAEKSQ KDPKEYLPFL NTLKKMETNY QRFTIDKYLK RYEKALGHLS
960 970 980 990 1000
KCGPEYFTEC LNLIKDKNLY KEALKLYRPD SPQYQAVSVA YGEHLVQEHL
1010 1020 1030 1040 1050
YEPAGLVFAR CGAHEKALEA FLACGSWQQA LCMAAQLQMA KDKVAGLART
1060 1070 1080 1090 1100
LAGKLVEQRK HSEAATVLEQ YAQDYEEAVL LLLEGSAWEE ALRLVYKYDR
1110 1120 1130 1140 1150
VDIIETSVKP SILEAQKNYM DFLDSQTATF IRHKNRLKVV RELKSQAPRV
1160 1170 1180 1190 1200
HVDHEVAHGR ETDLFSETSS IRSGSEMSGR YSHSNSRISA RSSKNRRKAE
1210 1220 1230 1240 1250
RKKHSLKEGS PLEGLALLEA LSEVVQSIEK LKDEVHAILK VLFLFEFEEQ
1260 1270 1280 1290 1300
ARELQRAFES TLQLMGTALP DIWTLTGQQS SATPVLGPSS TVNSIMASYQ
1310 1320 1330
QQKTCVPVLD AWACLPPKID QRSQWKLSLL E
Length:1,331
Mass (Da):149,199
Last modified:April 3, 2013 - v2
Checksum:iFEA210441C537C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07048324 Genomic DNA. No translation available.
AABR07048325 Genomic DNA. No translation available.
CH474039 Genomic DNA. Translation: EDL91690.1.
UniGeneiRn.162816.

Genome annotation databases

EnsembliENSRNOT00000022836; ENSRNOP00000022836; ENSRNOG00000016725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07048324 Genomic DNA. No translation available.
AABR07048325 Genomic DNA. No translation available.
CH474039 Genomic DNA. Translation: EDL91690.1.
UniGeneiRn.162816.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022836.

Proteomic databases

PeptideAtlasiF1LP76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022836; ENSRNOP00000022836; ENSRNOG00000016725.

Organism-specific databases

RGDi620072. Ikbkap.

Phylogenomic databases

eggNOGiKOG1920. Eukaryota.
COG5290. LUCA.
GeneTreeiENSGT00390000013344.
OMAiCIASWDA.
OrthoDBiEOG091G01A5.
TreeFamiTF300402.

Gene expression databases

BgeeiENSRNOG00000016725.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR006849. Iki3.
[Graphical view]
PANTHERiPTHR12747. PTHR12747. 1 hit.
PfamiPF04762. IKI3. 1 hit.
[Graphical view]
PIRSFiPIRSF017233. IKAP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF1LP76_RAT
AccessioniPrimary (citable) accession number: F1LP76
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: November 2, 2016
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.