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Protein

Acyl-coenzyme A oxidase

Gene

Acox2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei437Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

ReactomeiR-RNO-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-RNO-389887. Beta-oxidation of pristanoyl-CoA.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidaseUniRule annotation
Gene namesi
Name:Acox2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi628684. Acox2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiF1LNW3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007378.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 148Acyl-CoA_ox_NInterPro annotationAdd BLAST116
Domaini151 – 260Acyl-CoA_dh_MInterPro annotationAdd BLAST110
Domaini496 – 674ACOXInterPro annotationAdd BLAST179

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0136. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00530000062919.
KOiK10214.
OMAiQKACVIA.
OrthoDBiEOG091G0A1P.
TreeFamiTF300672.

Family and domain databases

CDDicd01150. AXO. 1 hit.
Gene3Di1.10.540.10. 1 hit.
InterProiView protein in InterPro
IPR034171. ACO.
IPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR036250. AcylCo_DH-like_C.
IPR037069. AcylCoA_DH/ox_N_sf.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
PfamiView protein in Pfam
PF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LNW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPMHRVSL GDTWSWQVHP DIDSERHSPS FSVERLTNIL DGGLPNTVLR
60 70 80 90 100
RKVESIIQSD PVFNLKKLYF MTREELYEDA IQKRFHLEKL AWSLGWSEDG
110 120 130 140 150
PERIYANRVL DGNVNLSLHG VAMNAIRSLG SDEQIAKWGQ LCKNFQIITT
160 170 180 190 200
YAQTELGHGT YLQGLETEAT YDEARQEFVI HSPTMTSTKW WPGDLGWSVT
210 220 230 240 250
HAVVLAQLTC LGVRHGMHAF IVPIRSLEDH TPLPGITVGD IGPKMGLEHI
260 270 280 290 300
DNGFLQLNHV RVPRENMLSR FAEVLPDGTY QRLGTPQSNY LGMLVTRVQL
310 320 330 340 350
LCKGILPSLQ KACIIATRYS VIRHQSRLRP SDPEAKILEY QTQQQKLLPQ
360 370 380 390 400
LAVSYAFHFT ATSLSEFFHS SYSAILKRDF SLLPELHALS TGMKATFADF
410 420 430 440 450
CAQGAEICRR ACGGHGYSKL SGLPTLVARA TASCTYEGEN TVLYLQVARF
460 470 480 490 500
LMKSYLQAQA SPGATPQKPL PQSVMYIATQ RPARCSAQTA ADFRCPDVYT
510 520 530 540 550
TAWAYVSTRL IRDAAHRTQT LMKSGVDQHD AWNQTTVIHL QAAKAYCYFI
560 570 580 590 600
TVKNFKEAVE KLDKEPEIQR VLQRLCDLYA LHGVLTNSGD FLHDGFLSGA
610 620 630 640 650
QVDMAREAFL DLLPLIRKDA ILLTDAFDFS DHCLNSALGC YDGHVYERLF
660 670 680
EWAQKSPANT QENPAYKKYI RPLMLGWRHK M
Length:681
Mass (Da):76,747
Last modified:May 3, 2011 - v1
Checksum:i33B0292B5E2C240E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07017234 Genomic DNA. No translation available.
RefSeqiNP_665713.2. NM_145770.2.
XP_006251806.1. XM_006251744.2.
XP_006251807.1. XM_006251745.2.
UniGeneiRn.10622.

Genome annotation databases

EnsembliENSRNOT00000010260; ENSRNOP00000010260; ENSRNOG00000007378.
GeneIDi252898.
KEGGirno:252898.

Similar proteinsi

Entry informationi

Entry nameiF1LNW3_RAT
AccessioniPrimary (citable) accession number: F1LNW3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported