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Protein
Submitted name:

Protein Abca1

Gene

Abca1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-194223. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Abca1Imported
Gene namesi
Name:Abca1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi631344. Abca1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4622HelicalSequence analysisAdd
BLAST
Transmembranei640 – 66021HelicalSequence analysisAdd
BLAST
Transmembranei680 – 70425HelicalSequence analysisAdd
BLAST
Transmembranei716 – 74025HelicalSequence analysisAdd
BLAST
Transmembranei752 – 77120HelicalSequence analysisAdd
BLAST
Transmembranei777 – 79721HelicalSequence analysisAdd
BLAST
Transmembranei818 – 84225HelicalSequence analysisAdd
BLAST
Transmembranei1347 – 136822HelicalSequence analysisAdd
BLAST
Transmembranei1655 – 167723HelicalSequence analysisAdd
BLAST
Transmembranei1697 – 172327HelicalSequence analysisAdd
BLAST
Transmembranei1735 – 175420HelicalSequence analysisAdd
BLAST
Transmembranei1766 – 179025HelicalSequence analysisAdd
BLAST
Transmembranei1855 – 187521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF1LNL3.
PRIDEiF1LNL3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024564.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini899 – 1131233ABC transporterInterPro annotationAdd
BLAST
Domaini1912 – 2144233ABC transporterInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
InParanoidiF1LNL3.
OrthoDBiEOG78D7J6.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030365. ABCA1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF34. PTHR19229:SF34. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LNL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACWSQLRLL LWKNLTFRRR QTCQLLLEVA WPLFIFLILI SVRLSYPPYE
60 70 80 90 100
QHECHFPNKA MPSAGTLPWV QGIICNANNP CFRYPTPGEA PGVVGNFNKS
110 120 130 140 150
IVSRLFSDAQ RILLYSQKDT SIRDMHKVLR TLQQIKHPNS NLKLQDFLVD
160 170 180 190 200
NETFSGFLQH SLSLPRSAVD NLLQADVSLQ KVFLQGYQLH LASLCNGSKL
210 220 230 240 250
EEIIRLGDLE VSALCSLPRE KLDAAERELR SNMDILKPVM TKLNSTSLLP
260 270 280 290 300
TQHLAEATTT LLDSLGGLAQ ELFSTKSWSD MRQEVMFLTN VNNSGSSTQI
310 320 330 340 350
YQAVSRIVCG HPEGGGLKIK SLNWYEDNNY KALFGGNGTE EDTDTFYDNS
360 370 380 390 400
TTPYCNDLMK NLESSPLSRI IWKALKPLLI GKILYTPDTP ATRQVMAEVN
410 420 430 440 450
KTFQELALFH DLEGMWEELS PQIWTFMESS QEMDLVRTML DSRGNDQFWE
460 470 480 490 500
RKLDGLDWTA QDIMAFLAKN PEDVQSPNGS VYTWREAFNE TNQAIQTISR
510 520 530 540 550
FMECVNLNKL EPIPTEVRLI NKSMELLDER KFWAGIVFTG ITPDSVELPH
560 570 580 590 600
HVKYKIRMDI DNVERTNKIK DGYWDPGPRA DPFEDMRYVW GGFAYLQDVV
610 620 630 640 650
EQAIIRVLTG TEKKTGVYVQ QMPYPCYVDD IFLRVMSRSM PLFMTLAWIY
660 670 680 690 700
SVAVIIKSIV YEKEARLKET MRIMGLDNGI LWFSWFISSL IPLLVSAGLL
710 720 730 740 750
VIILKLGDLL PYSDPSVVFV FLSVFAVVTI LQCFLISTLF SRTNLAAACG
760 770 780 790 800
GIIYFTLYLP YVLCVAWQDY VGFSIKIFAS LLSPVAFGFG CEYFALFEEQ
810 820 830 840 850
GIGVQWDNLF KSPVEEDGFN LTTSVSMMLF DTFIYGVMTW YIEAVFPGQY
860 870 880 890 900
GIPRPWYFPC TKSYWFGEEI DEKSHPGSSQ KGASEICMEE EPTHLKLGVS
910 920 930 940 950
IQNLVKVYRD GMKVAVDGLA LNFYEGQITS FLGHNGAGKT TTMSILTGLF
960 970 980 990 1000
PPTSGTAYIL GKDIRSEMNS IRQNLGVCPQ HNVLFDMLTV EEHIWFYARL
1010 1020 1030 1040 1050
KGLSEKHVKA EMEQMALDVG LPPSKLKSKT SQLSGGMQRK LSVALAFVGG
1060 1070 1080 1090 1100
SKVVILDEPT AGVDPYSRRG IWELLLKYRQ GRTIILSTHH MDEADILGDR
1110 1120 1130 1140 1150
IAIISHGKLC CVGSSLFLKN QLGTGYYLTL VKKDVESSLS SCRNSSSTVS
1160 1170 1180 1190 1200
CLKKEDSVSQ SSSDAGLGSD HESDTLTIDV SAISNLIRKH VSEARLVEDI
1210 1220 1230 1240 1250
GHELTYVLPY EAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK
1260 1270 1280 1290 1300
VAEESGVDAE TSDGTLPARR NRRAFGDKQS CLHPFTEDDA VDPNDSDLDP
1310 1320 1330 1340 1350
ESRETDLLSG MDGKGSYQLK GWKLTQQQFV ALLWKRLLIA RRSRKGFFAQ
1360 1370 1380 1390 1400
IVLPAVFVCI ALVFSLIVPP FGKYPNLELQ PWMYNEQYTF VSNDAPEDMG
1410 1420 1430 1440 1450
TQELLNALTK DPGFGTRCME GNPIPNTPCL VGEEDWTTGP VPQTLMDLFQ
1460 1470 1480 1490 1500
NGNWTMKNPS PSCQCSSDKI KKMLPVCPPG AGGLPPPQRK QKTADILQNL
1510 1520 1530 1540 1550
TGRNISDYLV KTYVQIIAKS LKNKVWVNEF RYGGFSLGVS DSQALPPSQE
1560 1570 1580 1590 1600
VNNAIKQMKK LLKLTKDSSA DRFLSSLGRF MTGLDTKNNV KVWFNNKGWH
1610 1620 1630 1640 1650
AISSFLNVIN NAILRANLQK GENPSQYGIT AFNHPLNLTK QQLSEVALMT
1660 1670 1680 1690 1700
TSVDVLVSIC VIFAMSFVPA SFVVFLIQER VSKAKHLQFI CGVKPVIYWL
1710 1720 1730 1740 1750
SNFVWDMCNY VVPATLVVII FICFQQKSYV SSTNLPVLAL LLLLYGWSIT
1760 1770 1780 1790 1800
PLMYPASFVF KIPSTAYVVL TSVNLFIGIN GSVATFVLEL FTNNKFNDIN
1810 1820 1830 1840 1850
DILKSVFLIF PHFCLGRGLI DMVKNQAMAD ALERFGENRF VSPLSWDLVG
1860 1870 1880 1890 1900
RNENAMAVEG VVFFLVTVLI QYRFFIRPRP VKARLPPLND EDEDVRRERQ
1910 1920 1930 1940 1950
RILEGGGQND ILEIKELTKI YRRKRKPAVD RICVGIPPGE CFGLLGVNGA
1960 1970 1980 1990 2000
GKTSTFKMLT GDTAVTRGDA LLNKNSILSN IHEVHQNMGY CPQFDAITEL
2010 2020 2030 2040 2050
LTGREHLEFF ALLRGVPEKE VGKVGEWAIR KLGLVKYGEK YASNYSGGNK
2060 2070 2080 2090 2100
RKLSTAIALI GGPPVVFLDE PTTGMDPKAR RFLWNCALSI IKEGRSVVLT
2110 2120 2130 2140 2150
SHSMEECEAL CTRMAIMVNG RFRCLGSVQH LKNRFGDGYT IVVRIAGSNP
2160 2170 2180 2190 2200
DLKPVQEFFG LAFPGSVLKE KHRNMLQYQL PSSLSSLARI FSILSQSKKR
2210 2220 2230 2240 2250
LHIEDYSVSQ TTLDQVFVNF AKDQSDDDHL KDLSLHKNQT VVDVAVLTSF
2260
LQDEKVKESY V
Length:2,261
Mass (Da):253,990
Last modified:July 22, 2015 - v3
Checksum:i1E1FE16EDF81904A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07048271 Genomic DNA. No translation available.
AABR07048272 Genomic DNA. No translation available.
AABR07048273 Genomic DNA. No translation available.
RefSeqiXP_008761932.1. XM_008763710.1.
UniGeneiRn.148916.
Rn.231131.

Genome annotation databases

EnsembliENSRNOT00000024564; ENSRNOP00000024564; ENSRNOG00000018126.
GeneIDi313210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07048271 Genomic DNA. No translation available.
AABR07048272 Genomic DNA. No translation available.
AABR07048273 Genomic DNA. No translation available.
RefSeqiXP_008761932.1. XM_008763710.1.
UniGeneiRn.148916.
Rn.231131.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024564.

Proteomic databases

PaxDbiF1LNL3.
PRIDEiF1LNL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024564; ENSRNOP00000024564; ENSRNOG00000018126.
GeneIDi313210.

Organism-specific databases

CTDi19.
RGDi631344. Abca1.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
InParanoidiF1LNL3.
OrthoDBiEOG78D7J6.
TreeFamiTF105191.

Enzyme and pathway databases

ReactomeiR-RNO-194223. HDL-mediated lipid transport.

Miscellaneous databases

NextBioi35575844.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030365. ABCA1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF34. PTHR19229:SF34. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LNL3_RAT
AccessioniPrimary (citable) accession number: F1LNL3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: May 11, 2016
This is version 45 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.