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Protein

Phosphoinositide phospholipase C

Gene

Plcb4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei328UniRule annotation1
Active sitei375UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotationSAAS annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-112043 PLC beta mediated events
R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcb4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3345 Plcb4

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiF1LNK2

Expressioni

Gene expression databases

BgeeiENSRNOG00000033119
ExpressionAtlasiF1LNK2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF1LNK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 463PI-PLC X-boxInterPro annotationAdd BLAST151
Domaini566 – 682PI-PLC Y-boxInterPro annotationAdd BLAST117
Domaini689 – 787C2InterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili490 – 510Sequence analysisAdd BLAST21
Coiled coili923 – 953Sequence analysisAdd BLAST31
Coiled coili966 – 986Sequence analysisAdd BLAST21
Coiled coili1138 – 1168Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00760000118936

Family and domain databases

CDDicd13361 PH_PLC_beta, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR009535 PLC-beta_CS
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF06631 DUF1154, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PIRSFiPIRSF000956 PLC-beta, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

F1LNK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW
60 70 80 90 100
KSEGKEGQVL ECSLINSIRL AAIPKDPKIL AALESVGKSE NDLEGRILCV
110 120 130 140 150
CSGTDLVNIG FTYMVAENPE ITKQWVEGLR SIIHNFRANN VSPMTCLKKH
160 170 180 190 200
WMKLAFLTNT SGKIPVRSIT RTFASGKTEK VIFQALKELG LPSGKNDEIE
210 220 230 240 250
PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD QLVSFLNEHQ
260 270 280 290 300
RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE
310 320 330 340 350
NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL
360 370 380 390 400
LAGCRCVELD CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS
410 420 430 440 450
EYPVILSFEN HCSKYQQYKM SKYCEDLFGD LLLKQALESH PLEPGRPLPS
460 470 480 490 500
PNDLKRKILI KNKRLKPEVE KKQLEALKSM MEAGESAAPA SILEDDNEEE
510 520 530 540 550
IESAADQEEE AHPEYKFGNE LSADDFSHKE AVANSVKKGL VTVEDEQAWM
560 570 580 590 600
ASYKYVGATT NIHPYLSTMI NYAQPVKFQG FHVAEERNIH YNMSSFNESV
610 620 630 640 650
GLGYLKTHAI EFVNYNKRQM SRIYPKGGRV DSSNYMPQIF WNAGCQMVSL
660 670 680 690 700
NYQTPDLAMQ LNQGKFEYNG SCGYLLKPDF MRRPDRTFDP FSETPVDGVI
710 720 730 740 750
AATCSVQVIS GQFLSDKKIG TYVEVDMYGL PTDTIRKEFR TRMVMNNGLN
760 770 780 790 800
PVYNEESFVF RKVILPDLAV LRIAVYDDNN KLIGQRILPL DGLQAGYRHI
810 820 830 840 850
SLRNEGNKPL SLPTIFCNIV LKTYVPDGFG DIVDALSDPK KFLSITEKRA
860 870 880 890 900
DQMRAMGIET SDIADVPSDT SKNDKKGKAN PAKANVTPQS SSELRPTTTA
910 920 930 940 950
ALGSGQEAKK GIELIPQVRI EDLKQMKAYL KHLKKQQKEL NSLKKKHAKE
960 970 980 990 1000
HSTMQKLHCT QVDKIVAQYD KEKSTHEKIL EKAMKKKGGS NCLEIKKETE
1010 1020 1030 1040 1050
IKIQTLTSDH KSKVKEIVAQ HTKEWSEMIN THSAEEQEIR DLHLSQQCEL
1060 1070 1080 1090 1100
LRKLLINAHE QQTQQLKLSH DRESKEMRAH QAKISMENSK AISQDKSIKN
1110 1120 1130 1140 1150
KAERERRVRE LNSSNTKKFL EERKRLAMKQ SKEMDQLKKV QLEHLEFLEK
1160 1170
QNEQAKEMQQ MVKLEAEMDR RPATVV
Length:1,176
Mass (Da):134,570
Last modified:May 3, 2011 - v1
Checksum:i7D0DD3A07780A211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053821 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000042853; ENSRNOP00000048553; ENSRNOG00000033119

Similar proteinsi

Entry informationi

Entry nameiF1LNK2_RAT
AccessioniPrimary (citable) accession number: F1LNK2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health