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Protein

Phosphoinositide phospholipase C

Gene

Plcb4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei328UniRule annotation1
Active sitei375UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-112043. PLC beta mediated events.
R-RNO-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcb4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3345. Plcb4.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiF1LNK2.
PRIDEiF1LNK2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033119.
ExpressionAtlasiF1LNK2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF1LNK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 463PI-PLC X-boxInterPro annotationAdd BLAST151
Domaini566 – 682PI-PLC Y-boxInterPro annotationAdd BLAST117
Domaini689 – 787C2InterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili923 – 953Sequence analysisAdd BLAST31
Coiled coili1138 – 1168Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

F1LNK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW
60 70 80 90 100
KSEGKEGQVL ECSLINSIRL AAIPKDPKIL AALESVGKSE NDLEGRILCV
110 120 130 140 150
CSGTDLVNIG FTYMVAENPE ITKQWVEGLR SIIHNFRANN VSPMTCLKKH
160 170 180 190 200
WMKLAFLTNT SGKIPVRSIT RTFASGKTEK VIFQALKELG LPSGKNDEIE
210 220 230 240 250
PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD QLVSFLNEHQ
260 270 280 290 300
RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE
310 320 330 340 350
NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL
360 370 380 390 400
LAGCRCVELD CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS
410 420 430 440 450
EYPVILSFEN HCSKYQQYKM SKYCEDLFGD LLLKQALESH PLEPGRPLPS
460 470 480 490 500
PNDLKRKILI KNKRLKPEVE KKQLEALKSM MEAGESAAPA SILEDDNEEE
510 520 530 540 550
IESAADQEEE AHPEYKFGNE LSADDFSHKE AVANSVKKGL VTVEDEQAWM
560 570 580 590 600
ASYKYVGATT NIHPYLSTMI NYAQPVKFQG FHVAEERNIH YNMSSFNESV
610 620 630 640 650
GLGYLKTHAI EFVNYNKRQM SRIYPKGGRV DSSNYMPQIF WNAGCQMVSL
660 670 680 690 700
NYQTPDLAMQ LNQGKFEYNG SCGYLLKPDF MRRPDRTFDP FSETPVDGVI
710 720 730 740 750
AATCSVQVIS GQFLSDKKIG TYVEVDMYGL PTDTIRKEFR TRMVMNNGLN
760 770 780 790 800
PVYNEESFVF RKVILPDLAV LRIAVYDDNN KLIGQRILPL DGLQAGYRHI
810 820 830 840 850
SLRNEGNKPL SLPTIFCNIV LKTYVPDGFG DIVDALSDPK KFLSITEKRA
860 870 880 890 900
DQMRAMGIET SDIADVPSDT SKNDKKGKAN PAKANVTPQS SSELRPTTTA
910 920 930 940 950
ALGSGQEAKK GIELIPQVRI EDLKQMKAYL KHLKKQQKEL NSLKKKHAKE
960 970 980 990 1000
HSTMQKLHCT QVDKIVAQYD KEKSTHEKIL EKAMKKKGGS NCLEIKKETE
1010 1020 1030 1040 1050
IKIQTLTSDH KSKVKEIVAQ HTKEWSEMIN THSAEEQEIR DLHLSQQCEL
1060 1070 1080 1090 1100
LRKLLINAHE QQTQQLKLSH DRESKEMRAH QAKISMENSK AISQDKSIKN
1110 1120 1130 1140 1150
KAERERRVRE LNSSNTKKFL EERKRLAMKQ SKEMDQLKKV QLEHLEFLEK
1160 1170
QNEQAKEMQQ MVKLEAEMDR RPATVV
Length:1,176
Mass (Da):134,570
Last modified:May 3, 2011 - v1
Checksum:i7D0DD3A07780A211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053821 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000042853; ENSRNOP00000048553; ENSRNOG00000033119.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF1LNK2_RAT
AccessioniPrimary (citable) accession number: F1LNK2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported