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F1LNK2

- F1LNK2_RAT

UniProt

F1LNK2 - F1LNK2_RAT

Protein

Phosphoinositide phospholipase C

Gene

Plcb4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei328 – 3281UniRule annotation
    Active sitei375 – 3751UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotation, TransducerSAAS annotation

    Keywords - Biological processi

    Lipid degradationUniRule annotation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_198661. Synthesis of IP3 and IP4 in the cytosol.
    REACT_221588. PLC beta mediated events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
    Gene namesi
    Name:Plcb4Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi3345. Plcb4.

    PTM / Processingi

    Proteomic databases

    PRIDEiF1LNK2.

    Expressioni

    Gene expression databases

    ArrayExpressiF1LNK2.

    Structurei

    3D structure databases

    ProteinModelPortaliF1LNK2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains 1 PI-PLC X-box domain.UniRule annotation
    Contains 1 PI-PLC Y-box domain.UniRule annotation
    Contains C2 domain.SAAS annotation
    Contains PI-PLC X-box domain.SAAS annotation
    Contains PI-PLC Y-box domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110266.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000956. PLC-beta. 1 hit.
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LNK2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW     50
    KSEGKEGQVL ECSLINSIRL AAIPKDPKIL AALESVGKSE NDLEGRILCV 100
    CSGTDLVNIG FTYMVAENPE ITKQWVEGLR SIIHNFRANN VSPMTCLKKH 150
    WMKLAFLTNT SGKIPVRSIT RTFASGKTEK VIFQALKELG LPSGKNDEIE 200
    PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD QLVSFLNEHQ 250
    RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE 300
    NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL 350
    LAGCRCVELD CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS 400
    EYPVILSFEN HCSKYQQYKM SKYCEDLFGD LLLKQALESH PLEPGRPLPS 450
    PNDLKRKILI KNKRLKPEVE KKQLEALKSM MEAGESAAPA SILEDDNEEE 500
    IESAADQEEE AHPEYKFGNE LSADDFSHKE AVANSVKKGL VTVEDEQAWM 550
    ASYKYVGATT NIHPYLSTMI NYAQPVKFQG FHVAEERNIH YNMSSFNESV 600
    GLGYLKTHAI EFVNYNKRQM SRIYPKGGRV DSSNYMPQIF WNAGCQMVSL 650
    NYQTPDLAMQ LNQGKFEYNG SCGYLLKPDF MRRPDRTFDP FSETPVDGVI 700
    AATCSVQVIS GQFLSDKKIG TYVEVDMYGL PTDTIRKEFR TRMVMNNGLN 750
    PVYNEESFVF RKVILPDLAV LRIAVYDDNN KLIGQRILPL DGLQAGYRHI 800
    SLRNEGNKPL SLPTIFCNIV LKTYVPDGFG DIVDALSDPK KFLSITEKRA 850
    DQMRAMGIET SDIADVPSDT SKNDKKGKAN PAKANVTPQS SSELRPTTTA 900
    ALGSGQEAKK GIELIPQVRI EDLKQMKAYL KHLKKQQKEL NSLKKKHAKE 950
    HSTMQKLHCT QVDKIVAQYD KEKSTHEKIL EKAMKKKGGS NCLEIKKETE 1000
    IKIQTLTSDH KSKVKEIVAQ HTKEWSEMIN THSAEEQEIR DLHLSQQCEL 1050
    LRKLLINAHE QQTQQLKLSH DRESKEMRAH QAKISMENSK AISQDKSIKN 1100
    KAERERRVRE LNSSNTKKFL EERKRLAMKQ SKEMDQLKKV QLEHLEFLEK 1150
    QNEQAKEMQQ MVKLEAEMDR RPATVV 1176
    Length:1,176
    Mass (Da):134,570
    Last modified:May 3, 2011 - v1
    Checksum:i7D0DD3A07780A211
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06026347 Genomic DNA. No translation available.
    AABR06026348 Genomic DNA. No translation available.
    AABR06026349 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000042853; ENSRNOP00000048553; ENSRNOG00000033119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06026347 Genomic DNA. No translation available.
    AABR06026348 Genomic DNA. No translation available.
    AABR06026349 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F1LNK2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1LNK2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000042853 ; ENSRNOP00000048553 ; ENSRNOG00000033119 .

    Organism-specific databases

    RGDi 3345. Plcb4.

    Phylogenomic databases

    GeneTreei ENSGT00730000110266.

    Enzyme and pathway databases

    Reactomei REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
    REACT_221588. PLC beta mediated events.

    Miscellaneous databases

    NextBioi 35575833.

    Gene expression databases

    ArrayExpressi F1LNK2.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000956. PLC-beta. 1 hit.
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LNK2_RAT
    AccessioniPrimary (citable) accession number: F1LNK2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3