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F1LNK2

- F1LNK2_RAT

UniProt

F1LNK2 - F1LNK2_RAT

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Protein
Phosphoinositide phospholipase C
Gene
Plcb4
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei328 – 3281 By similarityUniRule annotation
Active sitei375 – 3751 By similarityUniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: InterPro
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. lipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotations

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_198661. Synthesis of IP3 and IP4 in the cytosol.
REACT_221588. PLC beta mediated events.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcb4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi3345. Plcb4.

PTM / Processingi

Proteomic databases

PRIDEiF1LNK2.

Expressioni

Gene expression databases

ArrayExpressiF1LNK2.

Structurei

3D structure databases

ProteinModelPortaliF1LNK2.

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains C2 domain.SAAS annotations
Contains Cdomain.SAAS annotations
Contains PI-PLC X-box domain.SAAS annotations
Contains PI-PLC Y-box domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110266.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LNK2-1 [UniParc]FASTAAdd to Basket

« Hide

MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW     50
KSEGKEGQVL ECSLINSIRL AAIPKDPKIL AALESVGKSE NDLEGRILCV 100
CSGTDLVNIG FTYMVAENPE ITKQWVEGLR SIIHNFRANN VSPMTCLKKH 150
WMKLAFLTNT SGKIPVRSIT RTFASGKTEK VIFQALKELG LPSGKNDEIE 200
PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD QLVSFLNEHQ 250
RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE 300
NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL 350
LAGCRCVELD CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS 400
EYPVILSFEN HCSKYQQYKM SKYCEDLFGD LLLKQALESH PLEPGRPLPS 450
PNDLKRKILI KNKRLKPEVE KKQLEALKSM MEAGESAAPA SILEDDNEEE 500
IESAADQEEE AHPEYKFGNE LSADDFSHKE AVANSVKKGL VTVEDEQAWM 550
ASYKYVGATT NIHPYLSTMI NYAQPVKFQG FHVAEERNIH YNMSSFNESV 600
GLGYLKTHAI EFVNYNKRQM SRIYPKGGRV DSSNYMPQIF WNAGCQMVSL 650
NYQTPDLAMQ LNQGKFEYNG SCGYLLKPDF MRRPDRTFDP FSETPVDGVI 700
AATCSVQVIS GQFLSDKKIG TYVEVDMYGL PTDTIRKEFR TRMVMNNGLN 750
PVYNEESFVF RKVILPDLAV LRIAVYDDNN KLIGQRILPL DGLQAGYRHI 800
SLRNEGNKPL SLPTIFCNIV LKTYVPDGFG DIVDALSDPK KFLSITEKRA 850
DQMRAMGIET SDIADVPSDT SKNDKKGKAN PAKANVTPQS SSELRPTTTA 900
ALGSGQEAKK GIELIPQVRI EDLKQMKAYL KHLKKQQKEL NSLKKKHAKE 950
HSTMQKLHCT QVDKIVAQYD KEKSTHEKIL EKAMKKKGGS NCLEIKKETE 1000
IKIQTLTSDH KSKVKEIVAQ HTKEWSEMIN THSAEEQEIR DLHLSQQCEL 1050
LRKLLINAHE QQTQQLKLSH DRESKEMRAH QAKISMENSK AISQDKSIKN 1100
KAERERRVRE LNSSNTKKFL EERKRLAMKQ SKEMDQLKKV QLEHLEFLEK 1150
QNEQAKEMQQ MVKLEAEMDR RPATVV 1176
Length:1,176
Mass (Da):134,570
Last modified:May 3, 2011 - v1
Checksum:i7D0DD3A07780A211
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06026347 Genomic DNA. No translation available.
AABR06026348 Genomic DNA. No translation available.
AABR06026349 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000042853; ENSRNOP00000048553; ENSRNOG00000033119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06026347 Genomic DNA. No translation available.
AABR06026348 Genomic DNA. No translation available.
AABR06026349 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F1LNK2.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1LNK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000042853 ; ENSRNOP00000048553 ; ENSRNOG00000033119 .

Organism-specific databases

RGDi 3345. Plcb4.

Phylogenomic databases

GeneTreei ENSGT00730000110266.

Enzyme and pathway databases

Reactomei REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
REACT_221588. PLC beta mediated events.

Miscellaneous databases

NextBioi 35575833.

Gene expression databases

ArrayExpressi F1LNK2.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
Pfami PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PIRSFi PIRSF000956. PLC-beta. 1 hit.
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LNK2_RAT
AccessioniPrimary (citable) accession number: F1LNK2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi