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Protein

Protein phosphatase 1G

Gene

Ppm1g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi60Manganese 2By similarity1
Metal bindingi61Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi438Manganese 2By similarity1
Metal bindingi493Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1GCurated (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase magnesium-dependent 1 gammaCurated
Gene namesi
Name:Ppm1gImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628676. Ppm1g.

Subcellular locationi

  • Cytoplasm Curated
  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004324292 – 542Protein phosphatase 1GAdd BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei22Omega-N-methylarginineBy similarity1
Modified residuei122PhosphothreonineBy similarity1
Modified residuei380N6-acetyllysineBy similarity1
Modified residuei524PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

PaxDbiF1LNI5.
PeptideAtlasiF1LNI5.
PRIDEiF1LNI5.

Expressioni

Gene expression databases

GenevisibleiF1LNI5. RN.

Interactioni

Subunit structurei

Interacts with NOL3; may dephosphorylate NOL3.1 Publication1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029414.

Structurei

3D structure databases

SMRiF1LNI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 502PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST477

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 319Glu-richPROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0699. Eukaryota.
COG0631. LUCA.
InParanoidiF1LNI5.
OrthoDBiEOG091G0D0W.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiView protein in Pfam
PF00481. PP2C. 2 hits.
SMARTiView protein in SMART
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiView protein in PROSITE
PS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F1LNI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
NETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALQDAFLA
110 120 130 140 150
IDAKLTTDEV IKELAQIAGR PTEDEDDKEK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCQKGPPH TKSGTGIGDE PEPQGLNGEA GPEDPSRETP
210 220 230 240 250
SQENGPTAKG HTGPSSNSDH GTEAGQIGEP GTATGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEVEEE EDDIEECSED EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDDEEMM VPGMEGKEEP GSDSGTTAVV ALIRGKQLIV ANAGDSRCVV
360 370 380 390 400
SEAGKALDMS YDHKPEDEVE LARIKNAGGK VTMDGRVNGG LNLSRAIGDH
410 420 430 440 450
FYKRNKNLPP QEQMISALPD IKVLTLTDDH EFMVIACDGI WNVMSSQEVV
460 470 480 490 500
DFIQSKISQR DENGELRLLS SIVEELLDQC LAPDTSGDGT GCDNMTCIII
510 520 530 540
CFKPRNTVEL QPESGKRKLE EALSTEGAEE NGNSDKKKAK RD
Length:542
Mass (Da):58,743
Last modified:April 3, 2013 - v2
Checksum:i189AB14A1E596F9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06042433 Genomic DNA. No translation available.
AABR06042434 Genomic DNA. No translation available.
AABR06042435 Genomic DNA. No translation available.
UniGeneiRn.16969.

Similar proteinsi

Entry informationi

Entry nameiPPM1G_RAT
AccessioniPrimary (citable) accession number: F1LNI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 3, 2013
Last modified: August 30, 2017
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families