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Protein

Ryanodine receptor 1

Gene

Ryr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ryanodine receptor 1
Short name:
RYR-1
Short name:
RyR1
Alternative name(s):
Skeletal muscle calcium release channel
Skeletal muscle ryanodine receptor
Skeletal muscle-type ryanodine receptor
Type 1 ryanodine receptor
Gene namesi
Name:Ryr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1586637. Ryr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 43234323CytoplasmicSequence analysisAdd
BLAST
Transmembranei4324 – 434421HelicalSequence analysisAdd
BLAST
Transmembranei4345 – 436521HelicalSequence analysisAdd
BLAST
Transmembranei4557 – 457721HelicalSequence analysisAdd
BLAST
Transmembranei4649 – 466921HelicalSequence analysisAdd
BLAST
Transmembranei4778 – 479821HelicalSequence analysisAdd
BLAST
Transmembranei4805 – 482521HelicalSequence analysisAdd
BLAST
Transmembranei4837 – 485721HelicalSequence analysisAdd
BLAST
Intramembranei4888 – 489710Pore-formingBy similarity
Transmembranei4918 – 493821HelicalSequence analysisAdd
BLAST
Topological domaini4939 – 503597CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extrinsic component of cytoplasmic side of plasma membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • sarcolemma Source: RGD
  • sarcoplasmic reticulum Source: RGD
  • sarcoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 50355035Ryanodine receptor 1PRO_0000415567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1338 – 13381PhosphoserineCombined sources
Modified residuei2344 – 23441PhosphoserineCombined sources
Modified residuei2840 – 28401PhosphoserineCombined sources
Modified residuei3634 – 36341S-nitrosocysteineBy similarity
Modified residuei4464 – 44641PhosphothreonineCombined sources
Modified residuei4468 – 44681PhosphoserineCombined sources
Modified residuei4861 – 48611PhosphotyrosineBy similarity
Modified residuei4864 – 48641PhosphoserineBy similarity

Post-translational modificationi

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2840 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2840 (By similarity).By similarity
Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiF1LMY4.

PTM databases

iPTMnetiF1LMY4.
PhosphoSiteiF1LMY4.

Expressioni

Tissue specificityi

Detected in myometrium smooth muscle.1 Publication

Interactioni

Subunit structurei

Homotetramer. Can also form heterotetramers with RYR2. Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity. Interacts with S100A1. Interacts with FKBP1A; this stabilizes the closed conformation of the channel. Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel. Interacts with CACNB1. Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1). Interacts with SEPN1 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-195292.
STRINGi10116.ENSRNOP00000027893.

Structurei

3D structure databases

ProteinModelPortaliF1LMY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 15456MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini161 – 20646MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini212 – 26655MIR 3PROSITE-ProRule annotationAdd
BLAST
Domaini272 – 32958MIR 4PROSITE-ProRule annotationAdd
BLAST
Domaini337 – 39458MIR 5PROSITE-ProRule annotationAdd
BLAST
Domaini583 – 799217B30.2/SPRY 1PROSITE-ProRule annotationAdd
BLAST
Repeati843 – 9561141Add
BLAST
Repeati957 – 10701142Add
BLAST
Domaini1015 – 1209195B30.2/SPRY 2PROSITE-ProRule annotationAdd
BLAST
Repeati1345 – 1360163; truncatedAdd
BLAST
Domaini1358 – 1571214B30.2/SPRY 3PROSITE-ProRule annotationAdd
BLAST
Repeati1373 – 1388164; truncatedAdd
BLAST
Repeati2723 – 28421205Add
BLAST
Repeati2843 – 29561146Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni843 – 295621146 X approximate repeatsAdd
BLAST
Regioni3613 – 364230Interaction with CALMBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1867 – 2087221Glu-richAdd
BLAST
Compositional biasi3681 – 376080Glu-richAdd
BLAST
Compositional biasi4459 – 452567Pro-richAdd
BLAST

Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum (SR) and the T-tubule.By similarity

Sequence similaritiesi

Contains 3 B30.2/SPRY domains.PROSITE-ProRule annotation
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOGENOMiHOG000231428.
HOVERGENiHBG102939.
InParanoidiF1LMY4.
TreeFamiTF315244.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR033215. RyR1.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PTHR13715:SF15. PTHR13715:SF15. 6 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LMY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL
60 70 80 90 100
EPTSNAQNVP PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR
110 120 130 140 150
TLLYGHAILL RHAHSRMYLS CLTTSRSMTD KLAFDVGLQE DATGEACWWT
160 170 180 190 200
MHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSTASGEL QVDASFMQTL
210 220 230 240 250
WNMNPICSCC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD DQRRLVYYEG
260 270 280 290 300
GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLALTEDQGL
310 320 330 340 350
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ
360 370 380 390 400
HVASGLWLTY AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ
410 420 430 440 450
AARMIYSTAG LYNQFIKGLD SFSGKPRGSG PPAGSALPIE GVILSLQDLI
460 470 480 490 500
GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ EEGMLSLVLN CIDRLNVYTT
510 520 530 540 550
AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL FSTNLDWLVS
560 570 580 590 600
KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV
610 620 630 640 650
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF
660 670 680 690 700
VGRAEGSTQY GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG
710 720 730 740 750
EGWGGNGVGD DLYSYGFDGL HLWTGHVARP VTSPGQHLLG PEDVVSCCLD
760 770 780 790 800
LSVPSISFRI NGCPVQGVFE SFNLDGLFFP VVSFSAGIKV RFLLGGRHGE
810 820 830 840 850
FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL VGPSRCLSHL
860 870 880 890 900
DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD
910 920 930 940 950
NKRLHPCLVD FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN
960 970 980 990 1000
LKKTKLPKTY MMNNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD
1010 1020 1030 1040 1050
RVAQGWSYSA VQDIPARRNP RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY
1060 1070 1080 1090 1100
GYNIEPPDQE PSQVDSQSRG DRARIFRAEK SYAVQSGRWY FEFEAVTTGR
1110 1120 1130 1140 1150
ELGWARPELR PDVELGADDL AYVFNGHRGQ RWHLGSEPFG RPWQSGDVVG
1160 1170 1180 1190 1200
CMIDLTENTI IFTLNGEVLM SDSGSETAFR EIEIGDGFLP VCSLGPGQVG
1210 1220 1230 1240 1250
HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEPVPL
1260 1270 1280 1290 1300
EHPHYEVARM DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFHQH
1310 1320 1330 1340 1350
FRCTAGATPL ASPGLQPPAE DEARAAEPDT DYENLRRSAG GWGEAEAGKD
1360 1370 1380 1390 1400
GTAKEGTPGG AAQPGVEAQP ARAENEKDAT TEKNKKRGFL FKAKKVAMMT
1410 1420 1430 1440 1450
QPPSTPALPR LPRDVVPADN RDDPEIILNT TTYYYSVRVF AGQEPSCVWV
1460 1470 1480 1490 1500
GWVTPDYHQH DMSFDLSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF
1510 1520 1530 1540 1550
VSPGQQGRIS HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP
1560 1570 1580 1590 1600
AVFVLPTHQN VVQFDLRPGA NIMPLSAAMF LSERKNPAPQ CPPRLEVQML
1610 1620 1630 1640 1650
MPVSWSRMPN HFLHVDTRRA GERLGWAVQC QEPLMMMALH IPEENSEPYI
1660 1670 1680 1690 1700
HLKRAQLDPR DLRDYRDTKF DSESSDSDQT PQPGCYHVDQ AQLLHALEDA
1710 1720 1730 1740 1750
HLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTEE TRAITLFPPG
1760 1770 1780 1790 1800
RSAEDGPRRH GLPGVGVTTS LRPPHHFSPP CFVVALPAAG AAEAPARLSP
1810 1820 1830 1840 1850
AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV
1860 1870 1880 1890 1900
MGVFSDEDVK QILKMIEPEV FTEEEEVEEE EEEEEEDEEE KEEDEEEEAH
1910 1920 1930 1940 1950
EKEDEEKEEA EEAAEEEKEE LEEGLLQMKL PESVKLQMCH LLEYFCDQEL
1960 1970 1980 1990 2000
QHRVESLAAF AERYVDKLQS NQRGRYGLLM KAFTMSAAET ARRTREFRSP
2010 2020 2030 2040 2050
PQEQINMLLQ FKNGADEEDC PLPEEIREDL VNFHQDLLAH CGIQLEGEEE
2060 2070 2080 2090 2100
EPEEESTLGS RLMSLLEKVR LVKKKEEKPE EEPAAEEHKP QSLQELVSHT
2110 2120 2130 2140 2150
VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISLSSVED
2160 2170 2180 2190 2200
TMSLLECLGQ IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL
2210 2220 2230 2240 2250
GMHETVMEVM VNVLGGGESK EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF
2260 2270 2280 2290 2300
DHLSYLLENS GIGLGMQGST PLDVAAASVI DNNELALALQ EQDLEKVVSY
2310 2320 2330 2340 2350
LAGCGLQSCP MLLAKGYPDI GWNPCGGERY LDFLRFAVFV NGESVEENAN
2360 2370 2380 2390 2400
VVVRLLIRKP ECFGPALRGE GGSGLLAAIE EAIRISEDPA RDGPGVRRDR
2410 2420 2430 2440 2450
RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQAGKGEAL
2460 2470 2480 2490 2500
RIRAILRSLV PLDDLVGIIS LPLQIPTLGK DGALVQPKMS ASFVPDHKAS
2510 2520 2530 2540 2550
MVLFLDRVYG IENQDFLLHV LDVGFLPDMR AAASLDTATF SRRWALALTR
2560 2570 2580 2590 2600
YLCAVLPLIT KCAPLLRGTE HRAIMVDSML HTVYRLSRGR SLTKAQRDVI
2610 2620 2630 2640 2650
EDCLMALCRY IRPSMLQHLL RRLVFDVPIL NEFAKMPLKL LTNHYERCWK
2660 2670 2680 2690 2700
YYCLPTGWAN FGVTSEEELH LTRKLFWGIF DSLAHKKYDQ ELYRIAMPCL
2710 2720 2730 2740 2750
CAIAGALPPD YVDASYSSKT EKKATVDAEG NFDPRPVETL NVIIPEKLDS
2760 2770 2780 2790 2800
FINKFAEYAH EKWAFDKIQN NWSYGENIDE ELKTHPMLRP YKTFSEKDKE
2810 2820 2830 2840 2850
IYRWPIKESL KAMIAWEWTV EKAREGEEEK TEKKKTRKIS QTAQTYDPRE
2860 2870 2880 2890 2900
GYNPQPPDLS VVTLSRELQA MAEQLAENYH NTWGRKKKQE LEAKGGGSHP
2910 2920 2930 2940 2950
LLVPYDTLTA KEKARDREKA QELLKFLQMN GYAVTRHGKD MELDTSSIEK
2960 2970 2980 2990 3000
RFAFGFLQQL LRWMDISQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL
3010 3020 3030 3040 3050
PLINQYFTNH CLYFLSTPAK VLGSGGHASN KEKEMITSLF CKLAALVRHR
3060 3070 3080 3090 3100
VSLFGTDAPA VVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESASEDI
3110 3120 3130 3140 3150
EKMVENLRLG KVSQARTQVK GVGQNLTYTT VALLPVLTTL FQHIAQHQFG
3160 3170 3180 3190 3200
DDVILDDVQV SCYRTLCSIY SLGTTRNPYV EKLRPALGEC LARLAAAMPV
3210 3220 3230 3240 3250
AFLEPELNEY NACSVYTTKS PRERAILGLP NSVEEMCPDI PVLERLMAEI
3260 3270 3280 3290 3300
GGLAESGARY TEMPHVIEIT LPMLCSYLPR WWERGPEAPP PALPAGAPPP
3310 3320 3330 3340 3350
CTAVTSDHLN SLLGNILRII VNNLGIDEAS WMKRLAVFAQ PIVSRARPEL
3360 3370 3380 3390 3400
LRSHFIPTIG RLRKRAGKVV AEEEQLRLEA KAEAEEGELL VRDEFSVLCR
3410 3420 3430 3440 3450
DLYALYPLLI RYVDNNRSAW PRLPPSPSSS FSLPSPSELG RWLMKDHGHQ
3460 3470 3480 3490 3500
LYEESFTVPL ILDNAAFPLA RNQSRAIGCA GVVRSGGSDQ ERTKKKRRGD
3510 3520 3530 3540 3550
RYSVQTSLIV ATLKKMLPIG LNMCAPTDQD LIVLAKARYA LKDTDEEVRE
3560 3570 3580 3590 3600
FLQNNLNLQG KVEGSPSLRW QMALYRGVPG REEDADDPEK IVRRVQEVSA
3610 3620 3630 3640 3650
VLYHLDQTEH PYKSKKAVWH KLLSKQRRRA VVACFRMTPL YNLPTHRACN
3660 3670 3680 3690 3700
MFLESYKASW ILTEDHSFED RMIDDLSKAG EQEEEEEEVE EKKPDPLHQL
3710 3720 3730 3740 3750
VLHFSRTALT EKSKLDEDYL YMAYADIMAK SCHLEEGGEN VEEGGEEEEV
3760 3770 3780 3790 3800
EVSFEEKEME KQRLLYQQSR LHNRGAAEMV LQMISACKGE TGAMVSSTLK
3810 3820 3830 3840 3850
LGISILNGGN AEVQQKMLDY LKDKKEVGFF QSIQALMQTC RWPHKTLSQR
3860 3870 3880 3890 3900
EGQEERVMKV QTSGTLVIIN RQNGEKVMAD DEFTQDLFRF LQLLCEGHNN
3910 3920 3930 3940 3950
DFQNYLRTQT GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG
3960 3970 3980 3990 4000
KRNFSKAMSV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA
4010 4020 4030 4040 4050
HMMMKLAQDS SQIELLKELL DLQKDMVVML LSLLEGNVVN GMIARQMVDM
4060 4070 4080 4090 4100
LVESSSNVEM ILKFFDMFLK LKDIVGSEAF QDYVTDPRGL ISKKDFQKAM
4110 4120 4130 4140 4150
DSQKQFTGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR DIGFNVAVLL
4160 4170 4180 4190 4200
TNLSEHVPHD PRLRNFLELA ESILDYFRPY LGRIEIMGAS RRIERIYFEI
4210 4220 4230 4240 4250
SETNRAQWEM PQVKESKRQF IFDVVNEGGE SEKMELFVSF CEDTIFEMQI
4260 4270 4280 4290 4300
AAQISEPEGE PEEDDDEGAE EAEEGAAGPD GSGSAAAAGV WTWLATAAGR
4310 4320 4330 4340 4350
TLRGLSYRSL RRRVRRLRRL TAREAATAVA VLLWAMVARA GGAGAGAAAG
4360 4370 4380 4390 4400
VLRLLWGSLF GGGLVDSAKK VTVTELLAGM PDPTGDEVHG QQPSGAGSDA
4410 4420 4430 4440 4450
EGEGQGEGEG DAAEGVGDEE VAADQAGTGG ADRTVAVADG SPFRPEGAGG
4460 4470 4480 4490 4500
LGDMGDTTPV EPPTPEGSPI LKRKLGVDGE EEEPQPEPEP EPEPEPEKAD
4510 4520 4530 4540 4550
TENGEKEVPE PPPEPPKKAP PPPPPKKEEA GGAGLEEFWG ELEVQRVKFL
4560 4570 4580 4590 4600
NYLSRNFYTL RFLALFLAFA INFILLFYKV SDSPPGEDDI EGSGAGDMSG
4610 4620 4630 4640 4650
AGSGDGSGWG SRASEEVEGD EDENMVYYFL EESTGYMEPA LRCLSLLHTL
4660 4670 4680 4690 4700
VAFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYITEQP EDDDVKGQWD
4710 4720 4730 4740 4750
RLVLNTPSFP SNYWDKFVKR KVLDKHGDIF GRERIAELLG MDLASLEITA
4760 4770 4780 4790 4800
HNERKPDPPP GLLTWIMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG
4810 4820 4830 4840 4850
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT
4860 4870 4880 4890 4900
VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
4910 4920 4930 4940 4950
DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE
4960 4970 4980 4990 5000
DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE
5010 5020 5030
HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLG
Length:5,035
Mass (Da):565,483
Last modified:May 3, 2011 - v1
Checksum:i51705805EDCAF5CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti673 – 6731A → V in AAD48899 (PubMed:10444400).Curated
Sequence conflicti4728 – 47281D → H in AAD31270 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112256 mRNA. Translation: AAD48899.1.
AF130879 mRNA. Translation: AAD31270.1.
AF011788 mRNA. Translation: AAB65756.1.
UniGeneiRn.225306.
Rn.87520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112256 mRNA. Translation: AAD48899.1.
AF130879 mRNA. Translation: AAD31270.1.
AF011788 mRNA. Translation: AAB65756.1.
UniGeneiRn.225306.
Rn.87520.

3D structure databases

ProteinModelPortaliF1LMY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-195292.
STRINGi10116.ENSRNOP00000027893.

PTM databases

iPTMnetiF1LMY4.
PhosphoSiteiF1LMY4.

Proteomic databases

PaxDbiF1LMY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1586637. Ryr1.

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOGENOMiHOG000231428.
HOVERGENiHBG102939.
InParanoidiF1LMY4.
TreeFamiTF315244.

Miscellaneous databases

PROiF1LMY4.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR033215. RyR1.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PTHR13715:SF15. PTHR13715:SF15. 6 hits.
PfamiPF13833. EF-hand_8. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRYR1_RAT
AccessioniPrimary (citable) accession number: F1LMY4
Secondary accession number(s): O35208, Q9R1G1, Q9R272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 3, 2011
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.