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F1LMP9

- F1LMP9_RAT

UniProt

F1LMP9 - F1LMP9_RAT

Protein
Submitted name:

Disabled homolog 2

Gene

Dab2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cargo receptor activity Source: Ensembl
    2. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl

    GO - Biological processi

    1. activation of JUN kinase activity Source: Ensembl
    2. cell morphogenesis involved in differentiation Source: Ensembl
    3. cellular response to transforming growth factor beta stimulus Source: Ensembl
    4. clathrin coat assembly Source: Ensembl
    5. endoderm development Source: Ensembl
    6. excretion Source: Ensembl
    7. in utero embryonic development Source: Ensembl
    8. myeloid cell differentiation Source: Ensembl
    9. negative regulation of androgen receptor signaling pathway Source: Ensembl
    10. negative regulation of apoptotic process Source: Ensembl
    11. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    12. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    13. negative regulation of protein binding Source: Ensembl
    14. negative regulation of transcription, DNA-templated Source: Ensembl
    15. pinocytosis Source: Ensembl
    16. positive regulation of cell migration Source: Ensembl
    17. positive regulation of clathrin-mediated endocytosis Source: Ensembl
    18. positive regulation of early endosome to late endosome transport Source: Ensembl
    19. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    20. positive regulation of integrin-mediated signaling pathway Source: Ensembl
    21. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    22. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    23. positive regulation of receptor recycling Source: Ensembl
    24. positive regulation of SMAD protein import into nucleus Source: Ensembl
    25. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
    26. positive regulation of transcription, DNA-templated Source: Ensembl
    27. positive regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
    28. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    29. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Disabled homolog 2Imported
    Gene namesi
    Name:Dab2Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi621007. Dab2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. clathrin coat of coated pit Source: Ensembl
    3. nucleus Source: Ensembl
    4. transforming growth factor beta receptor homodimeric complex Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00520000055585.
    OMAiLNGDVDY.
    OrthoDBiEOG7HQN7R.
    TreeFamiTF316724.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 1 hit.
    [Graphical view]
    PROSITEiPS01179. PID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LMP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNEVETSTT NGQPDQQAAP KAPSKKEKKK GSEKTDEYLL ARFKGDGVKY    50
    KAKLIGIDDV PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS 100
    GIKIIDEKTG VIEHEHPVNK ISFIARDVTD NRAFGYVCGG EGQHQFFAIK 150
    TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK KVEEANKAEE NGSEALMTLD 200
    DQANKLKLGV DQMDLFGDMS TPPDLNNPTE SRDILLVDLN SEIDTNQNSL 250
    RENPFLTNGV TSCSLPRPKP QASFLPESAF SANLNFFPTP NPDPFRDDPF 300
    AQPDQSAPSS FHSLTSADQK KANPGSLSTP QSKRPLNGDT DYFGQQFDQI 350
    SNRTGKQEAQ GGPWPYPSSQ TQQAVRTQNG VSEKQNGFHI KSSPNPFVGS 400
    PPKGLSVPNG VKQDLESSVQ SSAHDSIAII PPPQSTKPGR GRRTAKSSAN 450
    DLLASDIFAS EPPGQMSPTG QPAVPQANFM DLFKTSAPAP MGSGPLVGLG 500
    TVPVTPPQAG PWTPVVFTPS TTVVPGAIIS GQPSGFGQPL VFGTTPAVQV 550
    WNQPSSFATA ASPPPPAVWC PTTSVAPNTW SSTSPLGNPF QSSNIFPPST 600
    ISTQSFPQPM MSSVLVTPPQ PPPRNGPLKD TLSDAFTGLD PLGDKEVKEV 650
    KEMFKDFQLR QPPLVPSRKG ETPSSGTSSA FSSYFNNKVG IPQEHVDHDD 700
    FDANQLLNKI NEPPKPAPRQ GVLSGTKSAD NSLENPFSKG FSSTNPSVVS 750
    QPASSDAHRS PFGNPFA 767
    Length:767
    Mass (Da):82,347
    Last modified:April 3, 2013 - v2
    Checksum:i8B9271DF9AECEBC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06013336 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000050655; ENSRNOP00000043878; ENSRNOG00000028930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06013336 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000050655 ; ENSRNOP00000043878 ; ENSRNOG00000028930 .

    Organism-specific databases

    RGDi 621007. Dab2.

    Phylogenomic databases

    GeneTreei ENSGT00520000055585.
    OMAi LNGDVDY.
    OrthoDBi EOG7HQN7R.
    TreeFami TF316724.

    Miscellaneous databases

    NextBioi 35575567.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 1 hit.
    [Graphical view ]
    PROSITEi PS01179. PID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LMP9_RAT
    AccessioniPrimary (citable) accession number: F1LMP9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 24 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3