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F1LMP9

- F1LMP9_RAT

UniProt

F1LMP9 - F1LMP9_RAT

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Protein
Submitted name:

Disabled homolog 2

Gene
Dab2
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. cargo receptor activity Source: Ensembl
  2. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl

GO - Biological processi

  1. activation of JUN kinase activity Source: Ensembl
  2. cell morphogenesis involved in differentiation Source: Ensembl
  3. cellular response to transforming growth factor beta stimulus Source: Ensembl
  4. clathrin coat assembly Source: Ensembl
  5. endoderm development Source: Ensembl
  6. excretion Source: Ensembl
  7. in utero embryonic development Source: Ensembl
  8. myeloid cell differentiation Source: Ensembl
  9. negative regulation of androgen receptor signaling pathway Source: Ensembl
  10. negative regulation of apoptotic process Source: Ensembl
  11. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  12. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  13. negative regulation of protein binding Source: Ensembl
  14. negative regulation of transcription, DNA-templated Source: Ensembl
  15. pinocytosis Source: Ensembl
  16. positive regulation of cell migration Source: Ensembl
  17. positive regulation of clathrin-mediated endocytosis Source: Ensembl
  18. positive regulation of early endosome to late endosome transport Source: Ensembl
  19. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  20. positive regulation of integrin-mediated signaling pathway Source: Ensembl
  21. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  22. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  23. positive regulation of receptor recycling Source: Ensembl
  24. positive regulation of SMAD protein import into nucleus Source: Ensembl
  25. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
  26. positive regulation of transcription, DNA-templated Source: Ensembl
  27. positive regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  28. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  29. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Disabled homolog 2Imported
Gene namesi
Name:Dab2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi621007. Dab2.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. clathrin coat of coated pit Source: Ensembl
  3. nucleus Source: Ensembl
  4. transforming growth factor beta receptor homodimeric complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00520000055585.
OMAiLNGDVDY.
OrthoDBiEOG7HQN7R.
TreeFamiTF316724.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
[Graphical view]
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LMP9-1 [UniParc]FASTAAdd to Basket

« Hide

MSNEVETSTT NGQPDQQAAP KAPSKKEKKK GSEKTDEYLL ARFKGDGVKY    50
KAKLIGIDDV PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS 100
GIKIIDEKTG VIEHEHPVNK ISFIARDVTD NRAFGYVCGG EGQHQFFAIK 150
TGQQAEPLVV DLKDLFQVIY NVKKKEEEKK KVEEANKAEE NGSEALMTLD 200
DQANKLKLGV DQMDLFGDMS TPPDLNNPTE SRDILLVDLN SEIDTNQNSL 250
RENPFLTNGV TSCSLPRPKP QASFLPESAF SANLNFFPTP NPDPFRDDPF 300
AQPDQSAPSS FHSLTSADQK KANPGSLSTP QSKRPLNGDT DYFGQQFDQI 350
SNRTGKQEAQ GGPWPYPSSQ TQQAVRTQNG VSEKQNGFHI KSSPNPFVGS 400
PPKGLSVPNG VKQDLESSVQ SSAHDSIAII PPPQSTKPGR GRRTAKSSAN 450
DLLASDIFAS EPPGQMSPTG QPAVPQANFM DLFKTSAPAP MGSGPLVGLG 500
TVPVTPPQAG PWTPVVFTPS TTVVPGAIIS GQPSGFGQPL VFGTTPAVQV 550
WNQPSSFATA ASPPPPAVWC PTTSVAPNTW SSTSPLGNPF QSSNIFPPST 600
ISTQSFPQPM MSSVLVTPPQ PPPRNGPLKD TLSDAFTGLD PLGDKEVKEV 650
KEMFKDFQLR QPPLVPSRKG ETPSSGTSSA FSSYFNNKVG IPQEHVDHDD 700
FDANQLLNKI NEPPKPAPRQ GVLSGTKSAD NSLENPFSKG FSSTNPSVVS 750
QPASSDAHRS PFGNPFA 767
Length:767
Mass (Da):82,347
Last modified:April 3, 2013 - v2
Checksum:i8B9271DF9AECEBC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06013336 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000050655; ENSRNOP00000043878; ENSRNOG00000028930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06013336 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000050655 ; ENSRNOP00000043878 ; ENSRNOG00000028930 .

Organism-specific databases

RGDi 621007. Dab2.

Phylogenomic databases

GeneTreei ENSGT00520000055585.
OMAi LNGDVDY.
OrthoDBi EOG7HQN7R.
TreeFami TF316724.

Miscellaneous databases

NextBioi 35575567.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view ]
Pfami PF00640. PID. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 1 hit.
[Graphical view ]
PROSITEi PS01179. PID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LMP9_RAT
AccessioniPrimary (citable) accession number: F1LMP9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: May 14, 2014
This is version 23 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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