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Protein
Submitted name:

Protein Btrc

Gene

Btrc

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-1170546. Prolactin receptor signaling.
R-RNO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-RNO-195253. Degradation of beta-catenin by the destruction complex.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.
R-RNO-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-5610780. Degradation of GLI1 by the proteasome.
R-RNO-5610785. GLI3 is processed to GLI3R by the proteasome.
R-RNO-5676590. NIK-->noncanonical NF-kB signaling.
R-RNO-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein BtrcImported
Gene namesi
Name:BtrcImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359721. Btrc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiF1LMH8.
PRIDEiF1LMH8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016280.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022426.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 21039F-boxInterPro annotationAdd
BLAST
Domaini281 – 572292WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
GeneTreeiENSGT00760000119106.
InParanoidiF1LMH8.
OMAiWIQYLFK.
OrthoDBiEOG091G0437.
TreeFamiTF105679.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 6 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LMH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSLWLGCS SLADSMPSLR CLYNPGTGAL TAFQNSSERE DCNNGEPPRK
60 70 80 90 100
IIPEKNSLRQ TYNSCARLCI NQETVCLTST AMKTENCVAK TKLANGTSSM
110 120 130 140 150
IVPKQRKLSA SYEKEKELCV KYFEQWSESD QVEFVEHLIS QMCHYQHGHI
160 170 180 190 200
NSYLKPMLQR DFITALPARG LDHIAENILS YLDARSLCAA ELVCKEWYRV
210 220 230 240 250
TSDGMLWKKL IERMVRTDSL WRGLAERRGW GQYLFKNKPP DENAPPNSFY
260 270 280 290 300
RALYPKIIQD IETIESNWRC GRHSLQRIHC RSETSKGVYC LQYDDQKIVS
310 320 330 340 350
GLRDNTIKIW DKSTLECKRI LTGHTGSVLC LQYDERVIIT GSSDSTVRVW
360 370 380 390 400
DVNAGEMLNT LIHHCEAVLH LRFNNGMMVT CSKDRSIAVW DMASPTDITL
410 420 430 440 450
RRVLVGHRAA VNVVDFDDKY IVSASGDRTI KVWNTSTCEF VRTLNGHKRG
460 470 480 490 500
IACLQYRDRL VVSGSSDNTI RLWDIECGAC LRVLEGHEEL VRCIRFDNKR
510 520 530 540 550
IVSGAYDGKI KVWDLMAALD PRAPAGTLCL RTLVEHSGRV FRLQFDEFQI
560 570 580
VSSSHDDTIL IWDFLNDPAT HAEPPRSPSR TYTYISR
Length:587
Mass (Da):67,018
Last modified:July 22, 2015 - v2
Checksum:iBC271BBA07590A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111315 Genomic DNA. No translation available.
RefSeqiXP_006231597.1. XM_006231535.2.
UniGeneiRn.21800.

Genome annotation databases

EnsembliENSRNOT00000022426; ENSRNOP00000022426; ENSRNOG00000016280.
GeneIDi361765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111315 Genomic DNA. No translation available.
RefSeqiXP_006231597.1. XM_006231535.2.
UniGeneiRn.21800.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022426.

Proteomic databases

PaxDbiF1LMH8.
PRIDEiF1LMH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022426; ENSRNOP00000022426; ENSRNOG00000016280.
GeneIDi361765.

Organism-specific databases

CTDi8945.
RGDi1359721. Btrc.

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
GeneTreeiENSGT00760000119106.
InParanoidiF1LMH8.
OMAiWIQYLFK.
OrthoDBiEOG091G0437.
TreeFamiTF105679.

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-1170546. Prolactin receptor signaling.
R-RNO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-RNO-195253. Degradation of beta-catenin by the destruction complex.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.
R-RNO-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-5610780. Degradation of GLI1 by the proteasome.
R-RNO-5610785. GLI3 is processed to GLI3R by the proteasome.
R-RNO-5676590. NIK-->noncanonical NF-kB signaling.
R-RNO-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiENSRNOG00000016280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 6 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1LMH8_RAT
AccessioniPrimary (citable) accession number: F1LMH8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 7, 2016
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.