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Protein
Submitted name:

Beta-transducin repeat-containing E3 ubiquitin protein ligase

Gene

Btrc

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091 Activation of NF-kappaB in B cells
R-RNO-1170546 Prolactin receptor signaling
R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-202424 Downstream TCR signaling
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-3769402 Deactivation of the beta-catenin transactivating complex
R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5676590 NIK-->noncanonical NF-kB signaling
R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-RNO-8951664 Neddylation
R-RNO-9020702 Interleukin-1 signaling
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-transducin repeat-containing E3 ubiquitin protein ligaseImported
Gene namesi
Name:BtrcImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359721 Btrc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1LMH8
PRIDEiF1LMH8

Expressioni

Gene expression databases

BgeeiENSRNOG00000016280

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022426

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 210F-boxInterPro annotationAdd BLAST39
Domaini281 – 572WD_REPEATS_REGIONInterPro annotationAdd BLAST292
Repeati294 – 311WDPROSITE-ProRule annotationAdd BLAST18
Repeati321 – 360WDPROSITE-ProRule annotationAdd BLAST40
Repeati361 – 400WDPROSITE-ProRule annotationAdd BLAST40
Repeati404 – 443WDPROSITE-ProRule annotationAdd BLAST40
Repeati444 – 483WDPROSITE-ProRule annotationAdd BLAST40
Repeati484 – 515WDPROSITE-ProRule annotationAdd BLAST32
Repeati533 – 572WDPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0281 Eukaryota
ENOG410XTA8 LUCA
GeneTreeiENSGT00760000119106
InParanoidiF1LMH8
OMAiTQCCFPQ
OrthoDBiEOG091G0437
TreeFamiTF105679

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR021977 Beta-TrCP_D
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12125 Beta-TrCP_D, 1 hit
PF12937 F-box-like, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM01028 Beta-TrCP_D, 1 hit
SM00256 FBOX, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 6 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

F1LMH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSLWLGCS SLADSMPSLR CLYNPGTGAL TAFQNSSERE DCNNGEPPRK
60 70 80 90 100
IIPEKNSLRQ TYNSCARLCI NQETVCLTST AMKTENCVAK TKLANGTSSM
110 120 130 140 150
IVPKQRKLSA SYEKEKELCV KYFEQWSESD QVEFVEHLIS QMCHYQHGHI
160 170 180 190 200
NSYLKPMLQR DFITALPARG LDHIAENILS YLDARSLCAA ELVCKEWYRV
210 220 230 240 250
TSDGMLWKKL IERMVRTDSL WRGLAERRGW GQYLFKNKPP DENAPPNSFY
260 270 280 290 300
RALYPKIIQD IETIESNWRC GRHSLQRIHC RSETSKGVYC LQYDDQKIVS
310 320 330 340 350
GLRDNTIKIW DKSTLECKRI LTGHTGSVLC LQYDERVIIT GSSDSTVRVW
360 370 380 390 400
DVNAGEMLNT LIHHCEAVLH LRFNNGMMVT CSKDRSIAVW DMASPTDITL
410 420 430 440 450
RRVLVGHRAA VNVVDFDDKY IVSASGDRTI KVWNTSTCEF VRTLNGHKRG
460 470 480 490 500
IACLQYRDRL VVSGSSDNTI RLWDIECGAC LRVLEGHEEL VRCIRFDNKR
510 520 530 540 550
IVSGAYDGKI KVWDLMAALD PRAPAGTLCL RTLVEHSGRV FRLQFDEFQI
560 570 580
VSSSHDDTIL IWDFLNDPAT HAEPPRSPSR TYTYISR
Length:587
Mass (Da):67,018
Last modified:July 22, 2015 - v2
Checksum:iBC271BBA07590A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111315 Genomic DNA No translation available.
RefSeqiXP_006231597.1, XM_006231535.3
XP_017444943.1, XM_017589454.1
XP_017444944.1, XM_017589455.1
UniGeneiRn.21800

Genome annotation databases

EnsembliENSRNOT00000022426; ENSRNOP00000022426; ENSRNOG00000016280
GeneIDi361765

Similar proteinsi

Entry informationi

Entry nameiF1LMH8_RAT
AccessioniPrimary (citable) accession number: F1LMH8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: March 28, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health