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Protein

Phospholipase

Gene

Pld1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1483166 Synthesis of PA
R-RNO-2029485 Role of phospholipids in phagocytosis
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
PhospholipaseUniRule annotation (EC:3.1.4.4UniRule annotation)
Gene namesi
Name:Pld1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3349 Pld1

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiF1LMG4

Expressioni

Gene expression databases

BgeeiENSRNOG00000028156
ExpressionAtlasiF1LMG4 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 212PXInterPro annotationAdd BLAST132
Domaini219 – 328PHInterPro annotationAdd BLAST110
Domaini459 – 486PLD phosphodiesteraseInterPro annotationAdd BLAST28
Domaini891 – 918PLD phosphodiesteraseInterPro annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1329 Eukaryota
COG1502 LUCA
GeneTreeiENSGT00390000008356
TreeFamiTF300589

Family and domain databases

Gene3Di2.30.29.301 hit
3.30.1520.101 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001683 Phox
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
IPR016555 PLipase_D_euk
IPR015679 PLipase_D_fam
IPR036871 PX_dom_sf
PANTHERiPTHR18896 PTHR18896, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00614 PLDc, 1 hit
PF13091 PLDc_2, 1 hit
PF00787 PX, 1 hit
PIRSFiPIRSF009376 Phospholipase_D_euk, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00155 PLDc, 2 hits
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50035 PLD, 2 hits
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

F1LMG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKSEARVN TSTLQKIAAD MSNLIENLDT RELHFEGEEV EYDASPGDPT
60 70 80 90 100
AQEACIPFSS IYNTQGFKEP NIQIYLSGCP VKAQVLEVER FTSTSRMPSV
110 120 130 140 150
NLYTIELTHG EFTWQVKRKF KHFQEFHREL LKYKAFIRIP IPTKRHTFRR
160 170 180 190 200
QNVKEEPREM PSLPRSSENA IQEEQFFGRR KQLEDYLTKI LKMPMYRNYH
210 220 230 240 250
ATTEFLDVSQ LSFIHDLGPK GLEGMIMKRS GGHRIPGVNC CGHGRACYRW
260 270 280 290 300
SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFRIKVGKKE TETKYGLRID
310 320 330 340 350
NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTDFLKDHRF GSYAAVHENI
360 370 380 390 400
LAKWYVNAKG YFEDIANAME GATEEIFITD WWLSPEIFLK RPVVEGNRWR
410 420 430 440 450
LDCILKRKAQ QGVRIFIMLY KEVELALGIN SEYTKRTLMR LHPNIKVMRH
460 470 480 490 500
PDHVSSSVYL WAHHEKLVII DQSVAFVGGI DLAYGRWDDN EHRLTDVGSV
510 520 530 540 550
KRVTSGQSLG SLTAASVESM ESLSLKDKHQ SHKNEPVLKS VNDTDMKLKG
560 570 580 590 600
IGKSRKFSKF SLYRQLHRRN LHNSDSISSV DSASSYFNHY RSHQNLIHGL
610 620 630 640 650
KPHLKLFRPS SESEQGLTRH SADTGSIRSV QTGVGELHGE TRFWHGKDYC
660 670 680 690 700
NFVFKDWVQL DKPFADFIDR YSTPRMPWHD IGSVVHGKAA RDVARHFIQR
710 720 730 740 750
WNFTKIMKPK YRSLSYPFLL PKSQATAHEL RYQVPGAVHA KAQLLRSAAD
760 770 780 790 800
WSAGIKHHEE SIHAAYTHVI ENSKHYIYIE NQFFISCADD KVVFNKVGNA
810 820 830 840 850
IAQRILKAHR EGQRYRVYIV IPLLPGFEGD ISTGGGNALQ AIMHFNYRTM
860 870 880 890 900
CRGESSILEQ LKPELGNKWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL
910 920 930 940 950
IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR
960 970 980 990 1000
FAQGLRLECF RLVLGYLSDP SEDIQDPVSD KFFKEIWVST AARNATIYDK
1010 1020 1030 1040 1050
VFRCLPNDEV HNLIQLRDFI NKPILAKEDR LRAEEELRKI RGFLVQFPFY
1060 1070
FLSEENLLPS VGTKEAIVPM EVWT
Length:1,074
Mass (Da):123,786
Last modified:April 3, 2013 - v2
Checksum:i17560B13BF580A87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07009820 Genomic DNA No translation available.
AABR07009821 Genomic DNA No translation available.
AABR07009822 Genomic DNA No translation available.
AABR07009823 Genomic DNA No translation available.
AABR07009824 Genomic DNA No translation available.
RefSeqiXP_006232267.1, XM_006232205.3
XP_006232268.1, XM_006232206.3
XP_017446126.1, XM_017590637.1
UniGeneiRn.11130

Genome annotation databases

EnsembliENSRNOT00000039296; ENSRNOP00000034466; ENSRNOG00000028156
GeneIDi25096

Similar proteinsi

Entry informationi

Entry nameiF1LMG4_RAT
AccessioniPrimary (citable) accession number: F1LMG4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported