Gak

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein kinase activity Source: InterPro

GO - Biological processⁱ

Golgi organization Source: Ensembl
negative regulation of neuron projection development Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Cyclin-G-associated kinaseImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSRNOP00000000064
Gene namesⁱ	Name:GakImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSRNOP00000000064 RGD:621589
Organismⁱ	Rattus norvegicus (Rat)Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSRNOP00000000064 Proteomes:UP000002494
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 14

Organism-specific databases

RGDⁱ	621589. Gak.

Subcellular locationⁱ

GO - Cellular componentⁱ

Golgi apparatus Source: Ensembl
membrane Source: Ensembl
vesicle Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	F1LMD9.
PRIDEⁱ	F1LMD9.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000000048.

Bgeeⁱ

ENSRNOG00000000048.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000000064.

STRINGⁱ

10116.ENSRNOP00000000064.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Actions
Domainⁱ	40 – 317	278	Protein kinaseInterPro annotation Automatic assertion inferred from signature matchⁱ PROSITE:PS50011	Add BLAST
Domainⁱ	397 – 564	168	Phosphatase tensin-typeInterPro annotation Automatic assertion inferred from signature matchⁱ PROSITE:PS51181	Add BLAST
Domainⁱ	570 – 708	139	C2 tensin-typeInterPro annotation Automatic assertion inferred from signature matchⁱ PROSITE:PS51182	Add BLAST
Domainⁱ	1241 – 1305	65	JInterPro annotation Automatic assertion inferred from signature matchⁱ PROSITE:PS50076	Add BLAST

Phylogenomic databases

eggNOGⁱ	KOG0431. Eukaryota. KOG1989. Eukaryota. KOG2283. Eukaryota. ENOG410Y515. LUCA.
GeneTreeⁱ	ENSGT00760000119113.
OMAⁱ	KKNNIRA.
OrthoDBⁱ	EOG091G06HJ.
TreeFamⁱ	TF105165.

Family and domain databases

CDDⁱ	cd06257. DnaJ. 1 hit.
Gene3Dⁱ	1.10.287.110. 1 hit. 3.90.190.10. 1 hit.
InterProⁱ	IPR000008. C2_dom. IPR001623. DnaJ_domain. IPR011009. Kinase-like_dom. IPR029021. Prot-tyrosine_phosphatase-like. IPR000719. Prot_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR014020. Tensin_C2-dom. IPR029023. Tensin_lipid_phosphatase_dom. [Graphical view]
Pfamⁱ	PF00226. DnaJ. 1 hit. PF00069. Pkinase. 1 hit. PF10409. PTEN_C2. 1 hit. [Graphical view]
SMARTⁱ	SM00271. DnaJ. 1 hit. SM01326. PTEN_C2. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAMⁱ	SSF46565. SSF46565. 1 hit. SSF49562. SSF49562. 1 hit. SSF52799. SSF52799. 1 hit. SSF56112. SSF56112. 1 hit.
PROSITEⁱ	PS51182. C2_TENSIN. 1 hit. PS50076. DNAJ_2. 1 hit. PS51181. PPASE_TENSIN. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

F1LMD9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLLQSALDF LAGPGSLGGA AGRDQSDFVG QTVELGELRL RVRRVLAEGG 
        60         70         80         90        100
FAFVYEAQDL GSGREYALKR LLSNEEEKNR AIIQEVCFLK KLSGHPNIVQ 
       110        120        130        140        150
FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLRRVECK GPLSCDSILK 
       160        170        180        190        200
IFYQTCRAVQ HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH 
       210        220        230        240        250
YPDYSWSAQK RAMVEEEITR NTTPMYRTPE IVDLYSNFPI GEKQDIWALG 
       260        270        280        290        300
CILYLLCFRQ HPFEDGAKLR IVNGKYSIPV NDTRYTVFHD LIRGMLKVNP 
       310        320        330        340        350
EERLSIAEVV RQLQEIAAAR NVNPKAPITE LLEQNGGYGN SGPSRAQPPS 
       360        370        380        390        400
GGPVNSSGVL ALAEYDQPYG GFLDILRGGT ERLFTNLKDT SSKVIQSVAN 
       410        420        430        440        450
YAKGDLDISY ITSRIAVMSF PAEGVESAIK NNIEDVRLFL DAKHPGHYAV 
       460        470        480        490        500
YNLSPRIYRA SKFHNRVTEC GWAVRRAPHL HSLYTLCRSM HAWLREDHRN 
       510        520        530        540        550
VCVVHCMDGR AASAVAVCAF LCFCRLFSTA EAAVYMFSMK RCPPGIWPSH 
       560        570        580        590        600
KRYIEYVCDM VAEEPITPHS KPMLVKSVVM TPVPLFSKQR NGCRPFCEVY 
       610        620        630        640        650
VGEERVTTTS QEYDRMKEFK IEDGKAVIPL GITVQGDVLI IIYHARSTLG 
       660        670        680        690        700
GRLQAKMASM KMFQIQFHTG FVPRNATTVK FAKYDLDACD IQEKYPDLFQ 
       710        720        730        740        750
VNLEVEVEPR DRPSRDVPPW ENTSLRGLNP KILFSNREEQ QDILSKFGKP 
       760        770        780        790        800
ELPRQPGSTA QYDAEAGSPE AEITESDSPQ SSSTDTNHFL HTLDWQEEKD 
       810        820        830        840        850
PETGVDNTSP KESQSNLIAD GDGSEVSDEE EASCPSEERK PGAGEDTPRL 
       860        870        880        890        900
AAGTRQQDLI FDVGMLAAPQ EPVQPEEGVD LLGLHSEGDL RPAAPLQASG 
       910        920        930        940        950
VQSSNTDLLS SLLEPSDASQ VGPPGDLLGG ETPLLLASPV SLLGVQSNLQ 
       960        970        980        990       1000
GKVPDTVDPF DQFLLPSSSD TQPCSKPDLF GEFLNSDSVA SSTAFPSTHS 
      1010       1020       1030       1040       1050
APPPSCSTAF LHLGDLPAEP NKVIASSSHP DLLGGWDTWA ETALPGPASM 
      1060       1070       1080       1090       1100
PVPEGTLFSS AGHPAPPGPN PSQTKSQNPD PFADLSDLSS SLQGLPAGLP 
      1110       1120       1130       1140       1150
AGSFVGTSAT THKSNSSWQT TRPTAPGTSW PPQAKPAPRA SEQLRSHFSV 
      1160       1170       1180       1190       1200
IGAREERGVR APSFAQKPKV SENDFEDLLP NQGFSKSDKK GPKTMAEMRK 
      1210       1220       1230       1240       1250
QELARDTDPF KLKLLDWIEG KERNIRALLS TLHTVLWDGE SRWTPVSMAD 
      1260       1270       1280       1290       1300
LVTPEQVKKQ YRRAVLVVHP DKATGQPYEQ SAKMIFMELN DAWSEFENQG 

SRPLF

Length:1,305

Mass (Da):143,715

Last modified:May 3, 2011 - v1

Checksum:ⁱ85E2C40F84D520C6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC106245 Genomic DNA. No translation available. AC117047 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC106245 Genomic DNA. No translation available.
AC117047 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Ensemblⁱ

ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC106245 Genomic DNA. No translation available. AC117047 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC106245 Genomic DNA. No translation available.
AC117047 Genomic DNA. No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000000064.

STRINGⁱ

10116.ENSRNOP00000000064.

Proteomic databases

PaxDbⁱ	F1LMD9.
PRIDEⁱ	F1LMD9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Ensemblⁱ

ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Organism-specific databases

RGDⁱ	621589. Gak.

Phylogenomic databases

eggNOGⁱ	KOG0431. Eukaryota. KOG1989. Eukaryota. KOG2283. Eukaryota. ENOG410Y515. LUCA.
GeneTreeⁱ	ENSGT00760000119113.
OMAⁱ	KKNNIRA.
OrthoDBⁱ	EOG091G06HJ.
TreeFamⁱ	TF105165.

Gene expression databases

Bgeeⁱ	ENSRNOG00000000048.

Bgeeⁱ

ENSRNOG00000000048.

Family and domain databases

CDDⁱ	cd06257. DnaJ. 1 hit.
Gene3Dⁱ	1.10.287.110. 1 hit. 3.90.190.10. 1 hit.
InterProⁱ	IPR000008. C2_dom. IPR001623. DnaJ_domain. IPR011009. Kinase-like_dom. IPR029021. Prot-tyrosine_phosphatase-like. IPR000719. Prot_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR014020. Tensin_C2-dom. IPR029023. Tensin_lipid_phosphatase_dom. [Graphical view]
Pfamⁱ	PF00226. DnaJ. 1 hit. PF00069. Pkinase. 1 hit. PF10409. PTEN_C2. 1 hit. [Graphical view]
SMARTⁱ	SM00271. DnaJ. 1 hit. SM01326. PTEN_C2. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAMⁱ	SSF46565. SSF46565. 1 hit. SSF49562. SSF49562. 1 hit. SSF52799. SSF52799. 1 hit. SSF56112. SSF56112. 1 hit.
PROSITEⁱ	PS51182. C2_TENSIN. 1 hit. PS50076. DNAJ_2. 1 hit. PS51181. PPASE_TENSIN. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

F1LMD9_RAT

Accessionⁱ

Primary (citable) accession number: F1LMD9

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	September 7, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F1LMD9 (F1LMD9_RAT)

UniProt

F1LMD9 - F1LMD9_RAT

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Cyclin-G-associated kinase

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ