Gak

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein kinase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

clathrin coat disassembly Source: Ensembl
clathrin-coated pit assembly Source: Ensembl
clathrin-dependent endocytosis Source: Ensembl
Golgi organization Source: Ensembl
Golgi to lysosome transport Source: Ensembl
negative regulation of neuron projection development Source: Ensembl
protein localization to Golgi apparatus Source: Ensembl
protein localization to plasma membrane Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-432722 Golgi Associated Vesicle Biogenesis R-RNO-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-RNO-432722 Golgi Associated Vesicle Biogenesis
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Cyclin-G-associated kinaseImported
Gene namesⁱ	Name:GakImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 14

Organism-specific databases

Rat genome database More...RGDⁱ	621589 Gak

RGDⁱ

621589 Gak

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	F1LMD9

PRIDEⁱ

F1LMD9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000000048

Bgeeⁱ

ENSRNOG00000000048

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	40 – 317	Protein kinaseInterPro annotationAdd BLAST	278
Domainⁱ	397 – 564	Phosphatase tensin-typeInterPro annotationAdd BLAST	168
Domainⁱ	570 – 708	C2 tensin-typeInterPro annotationAdd BLAST	139
Domainⁱ	1241 – 1305	JInterPro annotationAdd BLAST	65

Phylogenomic databases

eggNOGⁱ	KOG0431 Eukaryota KOG1989 Eukaryota KOG2283 Eukaryota ENOG410Y515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119113
OMAⁱ	RPSRFHN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06HJ
TreeFamⁱ	TF105165

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.1101 hit 3.90.190.101 hit
InterProⁱ	View protein in InterPro IPR001623 DnaJ_domain IPR036869 J_dom_sf IPR011009 Kinase-like_dom_sf IPR029021 Prot-tyrosine_phosphatase-like IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR014020 Tensin_C2-dom IPR029023 Tensin_phosphatase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF00069 Pkinase, 1 hit PF10409 PTEN_C2, 1 hit
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit SM01326 PTEN_C2, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF52799 SSF52799, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51182 C2_TENSIN, 1 hit PS50076 DNAJ_2, 1 hit PS51181 PPASE_TENSIN, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F1LMD9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLLQSALDF LAGPGSLGGA AGRDQSDFVG QTVELGELRL RVRRVLAEGG 
        60         70         80         90        100
FAFVYEAQDL GSGREYALKR LLSNEEEKNR AIIQEVCFLK KLSGHPNIVQ 
       110        120        130        140        150
FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLRRVECK GPLSCDSILK 
       160        170        180        190        200
IFYQTCRAVQ HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH 
       210        220        230        240        250
YPDYSWSAQK RAMVEEEITR NTTPMYRTPE IVDLYSNFPI GEKQDIWALG 
       260        270        280        290        300
CILYLLCFRQ HPFEDGAKLR IVNGKYSIPV NDTRYTVFHD LIRGMLKVNP 
       310        320        330        340        350
EERLSIAEVV RQLQEIAAAR NVNPKAPITE LLEQNGGYGN SGPSRAQPPS 
       360        370        380        390        400
GGPVNSSGVL ALAEYDQPYG GFLDILRGGT ERLFTNLKDT SSKVIQSVAN 
       410        420        430        440        450
YAKGDLDISY ITSRIAVMSF PAEGVESAIK NNIEDVRLFL DAKHPGHYAV 
       460        470        480        490        500
YNLSPRIYRA SKFHNRVTEC GWAVRRAPHL HSLYTLCRSM HAWLREDHRN 
       510        520        530        540        550
VCVVHCMDGR AASAVAVCAF LCFCRLFSTA EAAVYMFSMK RCPPGIWPSH 
       560        570        580        590        600
KRYIEYVCDM VAEEPITPHS KPMLVKSVVM TPVPLFSKQR NGCRPFCEVY 
       610        620        630        640        650
VGEERVTTTS QEYDRMKEFK IEDGKAVIPL GITVQGDVLI IIYHARSTLG 
       660        670        680        690        700
GRLQAKMASM KMFQIQFHTG FVPRNATTVK FAKYDLDACD IQEKYPDLFQ 
       710        720        730        740        750
VNLEVEVEPR DRPSRDVPPW ENTSLRGLNP KILFSNREEQ QDILSKFGKP 
       760        770        780        790        800
ELPRQPGSTA QYDAEAGSPE AEITESDSPQ SSSTDTNHFL HTLDWQEEKD 
       810        820        830        840        850
PETGVDNTSP KESQSNLIAD GDGSEVSDEE EASCPSEERK PGAGEDTPRL 
       860        870        880        890        900
AAGTRQQDLI FDVGMLAAPQ EPVQPEEGVD LLGLHSEGDL RPAAPLQASG 
       910        920        930        940        950
VQSSNTDLLS SLLEPSDASQ VGPPGDLLGG ETPLLLASPV SLLGVQSNLQ 
       960        970        980        990       1000
GKVPDTVDPF DQFLLPSSSD TQPCSKPDLF GEFLNSDSVA SSTAFPSTHS 
      1010       1020       1030       1040       1050
APPPSCSTAF LHLGDLPAEP NKVIASSSHP DLLGGWDTWA ETALPGPASM 
      1060       1070       1080       1090       1100
PVPEGTLFSS AGHPAPPGPN PSQTKSQNPD PFADLSDLSS SLQGLPAGLP 
      1110       1120       1130       1140       1150
AGSFVGTSAT THKSNSSWQT TRPTAPGTSW PPQAKPAPRA SEQLRSHFSV 
      1160       1170       1180       1190       1200
IGAREERGVR APSFAQKPKV SENDFEDLLP NQGFSKSDKK GPKTMAEMRK 
      1210       1220       1230       1240       1250
QELARDTDPF KLKLLDWIEG KERNIRALLS TLHTVLWDGE SRWTPVSMAD 
      1260       1270       1280       1290       1300
LVTPEQVKKQ YRRAVLVVHP DKATGQPYEQ SAKMIFMELN DAWSEFENQG 

SRPLF

Length:1,305

Mass (Da):143,715

Last modified:May 3, 2011 - v1

Checksum:ⁱ85E2C40F84D520C6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC106245 Genomic DNA No translation available. AC117047 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC106245 Genomic DNA No translation available.
AC117047 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048

Ensemblⁱ

ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F1LMD9	Q99KY4 UPI000A309FE3 UPI000A30A2AC UPI000A30E790 P97874 UPI00015510D0 A0A0R4J0F6 UPI00038906C6 UPI0003890177 Q3UDE5 +5	Mus musculus (Mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Rattus norvegicus (Rat) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	1,305	UniRef90_Q99KY4	Cluster: Cyclin-G-associated kinase	16

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F1LMD9	Q99KY4 UPI000A309FE3 UPI000A30A2AC UPI000A30E790 Q3UIZ0 A0A0R4J0F6 UPI00038906C6 UPI0003890177 Q3UDE5 UPI00015510D0 +68	Mus musculus (Mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Rattus norvegicus (Rat) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Bos taurus (Bovine) Myotis brandtii (Brandt's bat) Pan troglodytes (Chimpanzee) Capra hircus (Goat) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	1,305	UniRef50_Q99KY4	Cluster: Cyclin-G-associated kinase	79

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC106245 Genomic DNA No translation available. AC117047 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC106245 Genomic DNA No translation available.
AC117047 Genomic DNA No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	F1LMD9

PRIDEⁱ

F1LMD9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048

Ensemblⁱ

ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048

Organism-specific databases

Rat genome database More...RGDⁱ	621589 Gak

RGDⁱ

621589 Gak

Phylogenomic databases

eggNOGⁱ	KOG0431 Eukaryota KOG1989 Eukaryota KOG2283 Eukaryota ENOG410Y515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119113
OMAⁱ	RPSRFHN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06HJ
TreeFamⁱ	TF105165

Enzyme and pathway databases

Reactomeⁱ	R-RNO-432722 Golgi Associated Vesicle Biogenesis R-RNO-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-RNO-432722 Golgi Associated Vesicle Biogenesis
R-RNO-8856828 Clathrin-mediated endocytosis

Gene expression databases

Bgeeⁱ	ENSRNOG00000000048

Bgeeⁱ

ENSRNOG00000000048

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.1101 hit 3.90.190.101 hit
InterProⁱ	View protein in InterPro IPR001623 DnaJ_domain IPR036869 J_dom_sf IPR011009 Kinase-like_dom_sf IPR029021 Prot-tyrosine_phosphatase-like IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR014020 Tensin_C2-dom IPR029023 Tensin_phosphatase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF00069 Pkinase, 1 hit PF10409 PTEN_C2, 1 hit
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit SM01326 PTEN_C2, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF52799 SSF52799, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51182 C2_TENSIN, 1 hit PS50076 DNAJ_2, 1 hit PS51181 PPASE_TENSIN, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1LMD9_RAT
Accessionⁱ	F1LMD9Primary (citable) accession number: F1LMD9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	May 3, 2011
	Last modified:	April 25, 2018
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F1LMD9 (F1LMD9_RAT)

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Cyclin-G-associated kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Golgi apparatus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ