Gak

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein kinase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

clathrin coat disassembly Source: Ensembl
clathrin-coated pit assembly Source: Ensembl
clathrin-dependent endocytosis Source: Ensembl
establishment of protein localization to Golgi Source: Ensembl
establishment of protein localization to plasma membrane Source: Ensembl
Golgi organization Source: Ensembl
Golgi to lysosome transport Source: Ensembl
negative regulation of neuron projection development Source: Ensembl

Complete GO annotation...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-432722. Golgi Associated Vesicle Biogenesis. R-RNO-8856828. Clathrin-mediated endocytosis.

Reactomeⁱ

R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Cyclin-G-associated kinaseImported
Gene namesⁱ	Name:GakImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 14

Organism-specific databases

Rat genome database More...RGDⁱ	621589. Gak.

RGDⁱ

621589. Gak.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: GOC
Golgi apparatus Source: Ensembl
membrane Source: Ensembl
vesicle Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	F1LMD9.
PRIDEⁱ	F1LMD9.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000000048.

Bgeeⁱ

ENSRNOG00000000048.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000000064.

STRINGⁱ

10116.ENSRNOP00000000064.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	40 – 317	Protein kinaseInterPro annotationAdd BLAST	278
Domainⁱ	397 – 564	Phosphatase tensin-typeInterPro annotationAdd BLAST	168
Domainⁱ	570 – 708	C2 tensin-typeInterPro annotationAdd BLAST	139
Domainⁱ	1241 – 1305	JInterPro annotationAdd BLAST	65

Phylogenomic databases

eggNOGⁱ	KOG0431. Eukaryota. KOG1989. Eukaryota. KOG2283. Eukaryota. ENOG410Y515. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136426.
OMAⁱ	KKNNIRA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06HJ.
TreeFamⁱ	TF105165.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257. DnaJ. 1 hit.
Gene3Dⁱ	1.10.287.110. 1 hit. 3.90.190.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000008. C2_dom. IPR001623. DnaJ_domain. IPR011009. Kinase-like_dom. IPR029021. Prot-tyrosine_phosphatase-like. IPR000719. Prot_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR014020. Tensin_C2-dom. IPR029023. Tensin_phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226. DnaJ. 1 hit. PF00069. Pkinase. 1 hit. PF10409. PTEN_C2. 1 hit.
SMARTⁱ	View protein in SMART SM00271. DnaJ. 1 hit. SM01326. PTEN_C2. 1 hit. SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF46565. SSF46565. 1 hit. SSF49562. SSF49562. 1 hit. SSF52799. SSF52799. 1 hit. SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51182. C2_TENSIN. 1 hit. PS50076. DNAJ_2. 1 hit. PS51181. PPASE_TENSIN. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F1LMD9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLLQSALDF LAGPGSLGGA AGRDQSDFVG QTVELGELRL RVRRVLAEGG 
        60         70         80         90        100
FAFVYEAQDL GSGREYALKR LLSNEEEKNR AIIQEVCFLK KLSGHPNIVQ 
       110        120        130        140        150
FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLRRVECK GPLSCDSILK 
       160        170        180        190        200
IFYQTCRAVQ HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH 
       210        220        230        240        250
YPDYSWSAQK RAMVEEEITR NTTPMYRTPE IVDLYSNFPI GEKQDIWALG 
       260        270        280        290        300
CILYLLCFRQ HPFEDGAKLR IVNGKYSIPV NDTRYTVFHD LIRGMLKVNP 
       310        320        330        340        350
EERLSIAEVV RQLQEIAAAR NVNPKAPITE LLEQNGGYGN SGPSRAQPPS 
       360        370        380        390        400
GGPVNSSGVL ALAEYDQPYG GFLDILRGGT ERLFTNLKDT SSKVIQSVAN 
       410        420        430        440        450
YAKGDLDISY ITSRIAVMSF PAEGVESAIK NNIEDVRLFL DAKHPGHYAV 
       460        470        480        490        500
YNLSPRIYRA SKFHNRVTEC GWAVRRAPHL HSLYTLCRSM HAWLREDHRN 
       510        520        530        540        550
VCVVHCMDGR AASAVAVCAF LCFCRLFSTA EAAVYMFSMK RCPPGIWPSH 
       560        570        580        590        600
KRYIEYVCDM VAEEPITPHS KPMLVKSVVM TPVPLFSKQR NGCRPFCEVY 
       610        620        630        640        650
VGEERVTTTS QEYDRMKEFK IEDGKAVIPL GITVQGDVLI IIYHARSTLG 
       660        670        680        690        700
GRLQAKMASM KMFQIQFHTG FVPRNATTVK FAKYDLDACD IQEKYPDLFQ 
       710        720        730        740        750
VNLEVEVEPR DRPSRDVPPW ENTSLRGLNP KILFSNREEQ QDILSKFGKP 
       760        770        780        790        800
ELPRQPGSTA QYDAEAGSPE AEITESDSPQ SSSTDTNHFL HTLDWQEEKD 
       810        820        830        840        850
PETGVDNTSP KESQSNLIAD GDGSEVSDEE EASCPSEERK PGAGEDTPRL 
       860        870        880        890        900
AAGTRQQDLI FDVGMLAAPQ EPVQPEEGVD LLGLHSEGDL RPAAPLQASG 
       910        920        930        940        950
VQSSNTDLLS SLLEPSDASQ VGPPGDLLGG ETPLLLASPV SLLGVQSNLQ 
       960        970        980        990       1000
GKVPDTVDPF DQFLLPSSSD TQPCSKPDLF GEFLNSDSVA SSTAFPSTHS 
      1010       1020       1030       1040       1050
APPPSCSTAF LHLGDLPAEP NKVIASSSHP DLLGGWDTWA ETALPGPASM 
      1060       1070       1080       1090       1100
PVPEGTLFSS AGHPAPPGPN PSQTKSQNPD PFADLSDLSS SLQGLPAGLP 
      1110       1120       1130       1140       1150
AGSFVGTSAT THKSNSSWQT TRPTAPGTSW PPQAKPAPRA SEQLRSHFSV 
      1160       1170       1180       1190       1200
IGAREERGVR APSFAQKPKV SENDFEDLLP NQGFSKSDKK GPKTMAEMRK 
      1210       1220       1230       1240       1250
QELARDTDPF KLKLLDWIEG KERNIRALLS TLHTVLWDGE SRWTPVSMAD 
      1260       1270       1280       1290       1300
LVTPEQVKKQ YRRAVLVVHP DKATGQPYEQ SAKMIFMELN DAWSEFENQG 

SRPLF

Length:1,305

Mass (Da):143,715

Last modified:May 3, 2011 - v1

Checksum:ⁱ85E2C40F84D520C6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC106245 Genomic DNA. No translation available. AC117047 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC106245 Genomic DNA. No translation available.
AC117047 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Ensemblⁱ

ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC106245 Genomic DNA. No translation available. AC117047 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC106245 Genomic DNA. No translation available.
AC117047 Genomic DNA. No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000000064.

STRINGⁱ

10116.ENSRNOP00000000064.

Proteomic databases

PaxDbⁱ	F1LMD9.
PRIDEⁱ	F1LMD9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Ensemblⁱ

ENSRNOT00000000064; ENSRNOP00000000064; ENSRNOG00000000048.

Organism-specific databases

Rat genome database More...RGDⁱ	621589. Gak.

RGDⁱ

621589. Gak.

Phylogenomic databases

eggNOGⁱ	KOG0431. Eukaryota. KOG1989. Eukaryota. KOG2283. Eukaryota. ENOG410Y515. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136426.
OMAⁱ	KKNNIRA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06HJ.
TreeFamⁱ	TF105165.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-432722. Golgi Associated Vesicle Biogenesis. R-RNO-8856828. Clathrin-mediated endocytosis.

Reactomeⁱ

R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Gene expression databases

Bgeeⁱ	ENSRNOG00000000048.

Bgeeⁱ

ENSRNOG00000000048.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257. DnaJ. 1 hit.
Gene3Dⁱ	1.10.287.110. 1 hit. 3.90.190.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000008. C2_dom. IPR001623. DnaJ_domain. IPR011009. Kinase-like_dom. IPR029021. Prot-tyrosine_phosphatase-like. IPR000719. Prot_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR014020. Tensin_C2-dom. IPR029023. Tensin_phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226. DnaJ. 1 hit. PF00069. Pkinase. 1 hit. PF10409. PTEN_C2. 1 hit.
SMARTⁱ	View protein in SMART SM00271. DnaJ. 1 hit. SM01326. PTEN_C2. 1 hit. SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF46565. SSF46565. 1 hit. SSF49562. SSF49562. 1 hit. SSF52799. SSF52799. 1 hit. SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51182. C2_TENSIN. 1 hit. PS50076. DNAJ_2. 1 hit. PS51181. PPASE_TENSIN. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F1LMD9_RAT
Accessionⁱ	F1LMD9Primary (citable) accession number: F1LMD9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 3, 2011
	Last sequence update:	May 3, 2011
	Last modified:	May 10, 2017
	This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F1LMD9 (F1LMD9_RAT)

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Cyclin-G-associated kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ