F1LMA4 (F1LMA4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Beta-adrenergic receptor kinase 1 Ensembl ENSRNOP00000025847

Gene names

Name:

Adrbk1 Ensembl ENSRNOP00000025847

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000025847

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	652 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. RuleBase RU000308 Contains 1 AGC-kinase C-terminal domain. SAAS SAAS000961 Contains 1 PH domain. RuleBase RU003350 SAAS SAAS000961 Contains 1 RGS domain. RuleBase RU003298
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000025847

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 SAAS SAAS000961 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS000961 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle contraction Inferred from electronic annotation. Source: Compara desensitization of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara negative regulation of striated muscle contraction Inferred from electronic annotation. Source: Compara negative regulation of the force of heart contraction by chemical signal Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara receptor internalization Inferred from electronic annotation. Source: Compara tachykinin receptor signaling pathway Inferred from electronic annotation. Source: Compara termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activity Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	Ensembl ENSRNOP00000025847

Sequences

	Sequence		Length	Mass (Da)
	F1LMA4 [UniParc]. Last modified April 3, 2013. Version 2. Checksum: A35CECB3DEED2737	FASTA	652	75,709
	10 20 30 40 50 60 SIRSVMQKYL EDRGEVTFEK IFSQKLGYLL FRDFCLNHLE EAKPLVEFYE EIKKYEKLET 70 80 90 100 110 120 EEERVVRSRE IFDSYIMKEL LACSHPFSKN ATEHVQGHLV KKQVPPDLFQ PYIEEICQNL 130 140 150 160 170 180 RGDVFHKFIE SDKFTRFCQW KNVELNIHLT MNDFSVHRII GRGGFGEVYG CRKADTGKMY 190 200 210 220 230 240 AMKCLDKKRI KMKQGETLAL NERIMLSLVS TGDCPFIVCM SYAFHTPDKL SFILDLMNGG 250 260 270 280 290 300 DLHYHLSQHG VFSEADMRFY AAEIILGLEH MHNRFVVYRD LKPANILLDE HGHVRISDLG 310 320 330 340 350 360 LACDFSKKKP HASVGTHGYM APEVLQKGVA YDSSADWFSL GCMLFKLLRG HSPFRQHKTK 370 380 390 400 410 420 DKHEIDRMTL TMAVELPDSF SPELRSLLEG LLQRDVNRRL GCLGRGAQEV KESPFFRSLD 430 440 450 460 470 480 WQMVFLQKYP PPLIPPRGEV NAADAFDIGS FDEEDTKGIK LLDSDQELYR NFPLTISERW 490 500 510 520 530 540 QQEVAETVFD TINAETDRLE ARKKAKNKQL GHEEDYALGK DCIMHGYMSK MGNPFLTQWQ 550 560 570 580 590 600 RRYFYLFPNR LEWRGEGEAP QSLLTMEEIQ SVEETQIKER KCLLLKIRGG KQFVLQCDSD 610 620 630 640 650 PELVQWKKEL RDAYREAQQL VQRVPKMKNK PRSPVVELSK VPLIQRGSAN GL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000025847.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000025847.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06009499 Genomic DNA. No translation available.
IPI	IPI00196987.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	F1LMA4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000025847; ENSRNOP00000025847; ENSRNOG00000018985.
Organism-specific databases
RGD	2062. Adrbk1.
Phylogenomic databases
GeneTree	ENSGT00550000074318.
Gene expression databases
ArrayExpress	F1LMA4.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR011009. Kinase-like_dom. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00169. PH. 1 hit. PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR00717. GPCRKINASE.
SMART	SM00233. PH. 1 hit. SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35575443.

Entry information

Entry name

F1LMA4_RAT

Accession

Primary (citable) accession number: F1LMA4

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	April 3, 2013
Last modified:	May 1, 2013
This is version 18 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)