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Protein

G protein-coupled receptor kinase

Gene

Grk2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei280Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-111933 Calmodulin induced events
R-RNO-416476 G alpha (q) signalling events
R-RNO-418555 G alpha (s) signalling events
R-RNO-5635838 Activation of SMO

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinaseUniRule annotation (EC:2.7.11.-UniRule annotation)
Gene namesi
Name:Grk2Imported
Synonyms:Adrbk1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2062 Grk2

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiF1LMA4

Expressioni

Gene expression databases

BgeeiENSRNOG00000018985

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 138RGSInterPro annotationAdd BLAST122
Domaini154 – 416Protein kinaseInterPro annotationAdd BLAST263
Domaini417 – 484AGC-kinase C-terminalInterPro annotationAdd BLAST68
Domaini521 – 615PHInterPro annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili603 – 630Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
GeneTreeiENSGT00860000133699
OMAiSEAEMRF
OrthoDBiEOG091G0AEI
TreeFamiTF313940

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

F1LMA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SIRSVMQKYL EDRGEVTFEK IFSQKLGYLL FRDFCLNHLE EAKPLVEFYE
60 70 80 90 100
EIKKYEKLET EEERVVRSRE IFDSYIMKEL LACSHPFSKN ATEHVQGHLV
110 120 130 140 150
KKQVPPDLFQ PYIEEICQNL RGDVFHKFIE SDKFTRFCQW KNVELNIHLT
160 170 180 190 200
MNDFSVHRII GRGGFGEVYG CRKADTGKMY AMKCLDKKRI KMKQGETLAL
210 220 230 240 250
NERIMLSLVS TGDCPFIVCM SYAFHTPDKL SFILDLMNGG DLHYHLSQHG
260 270 280 290 300
VFSEADMRFY AAEIILGLEH MHNRFVVYRD LKPANILLDE HGHVRISDLG
310 320 330 340 350
LACDFSKKKP HASVGTHGYM APEVLQKGVA YDSSADWFSL GCMLFKLLRG
360 370 380 390 400
HSPFRQHKTK DKHEIDRMTL TMAVELPDSF SPELRSLLEG LLQRDVNRRL
410 420 430 440 450
GCLGRGAQEV KESPFFRSLD WQMVFLQKYP PPLIPPRGEV NAADAFDIGS
460 470 480 490 500
FDEEDTKGIK LLDSDQELYR NFPLTISERW QQEVAETVFD TINAETDRLE
510 520 530 540 550
ARKKAKNKQL GHEEDYALGK DCIMHGYMSK MGNPFLTQWQ RRYFYLFPNR
560 570 580 590 600
LEWRGEGEAP QSLLTMEEIQ SVEETQIKER KCLLLKIRGG KQFVLQCDSD
610 620 630 640 650
PELVQWKKEL RDAYREAQQL VQRVPKMKNK PRSPVVELSK VPLIQRGSAN

GL
Length:652
Mass (Da):75,709
Last modified:April 3, 2013 - v2
Checksum:iA35CECB3DEED2737
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006093 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000025847; ENSRNOP00000025847; ENSRNOG00000018985

Similar proteinsi

Entry informationi

Entry nameiF1LMA4_RAT
AccessioniPrimary (citable) accession number: F1LMA4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: May 23, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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