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F1LM57

- F1LM57_RAT

UniProt

F1LM57 - F1LM57_RAT

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Protein

DNA-directed RNA polymerase

Gene

Polr1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. ribonucleoside binding Source: InterPro

GO - Biological processi

  1. embryo implantation Source: Ensembl
  2. nucleologenesis Source: Ensembl
  3. rRNA transcription Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiREACT_206206. RNA Polymerase I Transcription Initiation.
REACT_218876. RNA Polymerase I Promoter Escape.
REACT_231914. RNA Polymerase I Transcription Termination.
REACT_259307. RNA Polymerase I Chain Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:Polr1bImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi620822. Polr1b.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. DNA-directed RNA polymerase I complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiF1LM57.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119399.
OMAiEVFAGVT.
OrthoDBiEOG77M8MW.

Family and domain databases

Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LM57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVDSRWRNL PSGPSLKHLT DPSYAVPPEQ QKAALQDLTR AHVDSFNYAV
60 70 80 90 100
LEGLSHAVQA IPPFEFAFKD ERISLTIVDA AISPPAVPKG TICKELNIYP
110 120 130 140 150
AECRGRRSTY RGKLTADISW AVNGVPKGII KQFLGYVPIM VKSKLCNLYN
160 170 180 190 200
LPPQVLIEHH EEAEEMGGYF IINGIEKVIR MLIMPRRNFP IAMIRPKWKS
210 220 230 240 250
RGLGYTQFGV SIHCVREEHS AVNMNLHYVE NGTVMLNFIY RKELFFLPLG
260 270 280 290 300
FALKALVSFS DYQIFQELIK GKEEDSFFKN SVSQMLRIVM EEGCHTQKQV
310 320 330 340 350
LDYLGERFRV KLSLPDWYPN AEAAEFLFNQ CICIHLKSNT DKFYLLCLMT
360 370 380 390 400
RKLFALARGE CMEDNPDSLV NQEVLTPGQL FLMFLKEKME NWLLSIKIAL
410 420 430 440 450
DKRAQKTNVS INNENLMKIF SMGTELTRPF EYLLATGNLR SKTGLGFMQD
460 470 480 490 500
SGLCVVADKL NFIRYLSHFR CVHRGADFAK MRTTTVRKLL PESWGFLCPV
510 520 530 540 550
HTPDGAPCGL LNHLTAVCEV VTKFVYTASI PALLCGLGVT PVDAAPCRPY
560 570 580 590 600
SDCYPVLLDG VMVGWVDKEL APEVADTLRR FKVLRERRSS LDGGGPDSHD
610 620 630 640 650
RKAKPVPRAV PLHHSLQAGE ACAEPGAGQR RARWNYGAAL HEHCHLRGRG
660 670 680 690 700
FWWSFHTPGA LPSQPAEVIA NFIPFSDHNQ SPRNMYQCQM GKQTMGFPLL
710 720 730 740 750
TYQDRSDNKL YRLQTPQSPL VRPCMYDHYD MDNYPIGTNA IVAVISYTGY
760 770 780 790 800
DMEDAMIVNK ASWERGFAHG SVYKSEFIDL SEKFKQGDDS LVFGVKPGDP
810 820 830 840 850
RVMQKLDNDG LPFIGAKLEF GDPYYGYLNL NTGEGFVVYY KSKENCVVDN
860 870 880 890 900
IKVCSNDTGS GKFKCVCVTV RVPRNPTIGD KFASRHGQKG ILSRLWPAED
910 920 930 940 950
MPFTESGMMP DILFNPHGFP SRMTIGMLIE SMAGKSAALH GLCHDATPFI
960 970 980 990 1000
FSEENSALEY FGEMLKAAGY NFYGTERLYS GISGMELEAD IFIGVVYYQR
1010 1020 1030 1040 1050
LRHMVSDKFQ VRTTGARDKV TNQPIGGRNV QGGIRFGEME RDALLAHGTS
1060 1070 1080 1090 1100
FLLHDRLFNC SDRSVAHVCV KCGSLLSPLL EKPPPSWSAM RNRKYNCTVC
1110 1120 1130
GRSDSIDTVS VPYVFRYFVA ELAAMNIKVK LDVI
Length:1,134
Mass (Da):127,669
Last modified:May 3, 2011 - v1
Checksum:i39DD5A8D6D58A6C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06026125 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000024882; ENSRNOP00000024882; ENSRNOG00000018349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06026125 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1LM57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024882 ; ENSRNOP00000024882 ; ENSRNOG00000018349 .

Organism-specific databases

RGDi 620822. Polr1b.

Phylogenomic databases

GeneTreei ENSGT00760000119399.
OMAi EVFAGVT.
OrthoDBi EOG77M8MW.

Enzyme and pathway databases

Reactomei REACT_206206. RNA Polymerase I Transcription Initiation.
REACT_218876. RNA Polymerase I Promoter Escape.
REACT_231914. RNA Polymerase I Transcription Termination.
REACT_259307. RNA Polymerase I Chain Elongation.

Miscellaneous databases

NextBioi 35575404.

Family and domain databases

Gene3Di 2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProi IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view ]
PANTHERi PTHR20856. PTHR20856. 1 hit.
Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view ]
PROSITEi PS01166. RNA_POL_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LM57_RAT
AccessioniPrimary (citable) accession number: F1LM57
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3