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Protein

DNA-directed RNA polymerase subunit beta

Gene

Polr1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-RNO-5250924 B-WICH complex positively regulates rRNA expression
R-RNO-73762 RNA Polymerase I Transcription Initiation
R-RNO-73772 RNA Polymerase I Promoter Escape
R-RNO-73777 RNA Polymerase I Chain Elongation
R-RNO-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:Polr1bImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620822 Polr1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000018349

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 415RNA_pol_Rpb2_1InterPro annotationAdd BLAST378
Domaini186 – 374RNA_pol_Rpb2_2InterPro annotationAdd BLAST189
Domaini456 – 520RNA_pol_Rpb2_3InterPro annotationAdd BLAST65
Domaini669 – 1029RNA_pol_Rpb2_6InterPro annotationAdd BLAST361
Domaini1032 – 1132RNA_pol_Rpb2_7InterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0216 Eukaryota
COG0085 LUCA
GeneTreeiENSGT00760000119399
OMAiAMNIKVK
OrthoDBiEOG091G00TJ

Family and domain databases

CDDicd00653 RNA_pol_B_RPB2, 1 hit
Gene3Di2.40.270.10, 3 hits
2.40.50.150, 2 hits
3.90.1110.10, 1 hit
InterProiView protein in InterPro
IPR015712 DNA-dir_RNA_pol_su2
IPR007120 DNA-dir_RNAP_su2_dom
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR007121 RNA_pol_bsu_CS
IPR007644 RNA_pol_bsu_protrusion
IPR007642 RNA_pol_Rpb2_2
IPR037034 RNA_pol_Rpb2_2_sf
IPR007645 RNA_pol_Rpb2_3
IPR007641 RNA_pol_Rpb2_7
IPR014724 RNA_pol_RPB2_OB-fold
PANTHERiPTHR20856 PTHR20856, 2 hits
PfamiView protein in Pfam
PF04563 RNA_pol_Rpb2_1, 1 hit
PF04561 RNA_pol_Rpb2_2, 1 hit
PF04565 RNA_pol_Rpb2_3, 1 hit
PF00562 RNA_pol_Rpb2_6, 1 hit
PF04560 RNA_pol_Rpb2_7, 1 hit
PROSITEiView protein in PROSITE
PS01166 RNA_POL_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

F1LM57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVDSRWRNL PSGPSLKHLT DPSYAVPPEQ QKAALQDLTR AHVDSFNYAV
60 70 80 90 100
LEGLSHAVQA IPPFEFAFKD ERISLTIVDA AISPPAVPKG TICKELNIYP
110 120 130 140 150
AECRGRRSTY RGKLTADISW AVNGVPKGII KQFLGYVPIM VKSKLCNLYN
160 170 180 190 200
LPPQVLIEHH EEAEEMGGYF IINGIEKVIR MLIMPRRNFP IAMIRPKWKS
210 220 230 240 250
RGLGYTQFGV SIHCVREEHS AVNMNLHYVE NGTVMLNFIY RKELFFLPLG
260 270 280 290 300
FALKALVSFS DYQIFQELIK GKEEDSFFKN SVSQMLRIVM EEGCHTQKQV
310 320 330 340 350
LDYLGERFRV KLSLPDWYPN AEAAEFLFNQ CICIHLKSNT DKFYLLCLMT
360 370 380 390 400
RKLFALARGE CMEDNPDSLV NQEVLTPGQL FLMFLKEKME NWLLSIKIAL
410 420 430 440 450
DKRAQKTNVS INNENLMKIF SMGTELTRPF EYLLATGNLR SKTGLGFMQD
460 470 480 490 500
SGLCVVADKL NFIRYLSHFR CVHRGADFAK MRTTTVRKLL PESWGFLCPV
510 520 530 540 550
HTPDGAPCGL LNHLTAVCEV VTKFVYTASI PALLCGLGVT PVDAAPCRPY
560 570 580 590 600
SDCYPVLLDG VMVGWVDKEL APEVADTLRR FKVLRERRSS LDGGGPDSHD
610 620 630 640 650
RKAKPVPRAV PLHHSLQAGE ACAEPGAGQR RARWNYGAAL HEHCHLRGRG
660 670 680 690 700
FWWSFHTPGA LPSQPAEVIA NFIPFSDHNQ SPRNMYQCQM GKQTMGFPLL
710 720 730 740 750
TYQDRSDNKL YRLQTPQSPL VRPCMYDHYD MDNYPIGTNA IVAVISYTGY
760 770 780 790 800
DMEDAMIVNK ASWERGFAHG SVYKSEFIDL SEKFKQGDDS LVFGVKPGDP
810 820 830 840 850
RVMQKLDNDG LPFIGAKLEF GDPYYGYLNL NTGEGFVVYY KSKENCVVDN
860 870 880 890 900
IKVCSNDTGS GKFKCVCVTV RVPRNPTIGD KFASRHGQKG ILSRLWPAED
910 920 930 940 950
MPFTESGMMP DILFNPHGFP SRMTIGMLIE SMAGKSAALH GLCHDATPFI
960 970 980 990 1000
FSEENSALEY FGEMLKAAGY NFYGTERLYS GISGMELEAD IFIGVVYYQR
1010 1020 1030 1040 1050
LRHMVSDKFQ VRTTGARDKV TNQPIGGRNV QGGIRFGEME RDALLAHGTS
1060 1070 1080 1090 1100
FLLHDRLFNC SDRSVAHVCV KCGSLLSPLL EKPPPSWSAM RNRKYNCTVC
1110 1120 1130
GRSDSIDTVS VPYVFRYFVA ELAAMNIKVK LDVI
Length:1,134
Mass (Da):127,669
Last modified:May 3, 2011 - v1
Checksum:i39DD5A8D6D58A6C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121664 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000024882; ENSRNOP00000024882; ENSRNOG00000018349

Similar proteinsi

Entry informationi

Entry nameiF1LM57_RAT
AccessioniPrimary (citable) accession number: F1LM57
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health