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F1LM57

- F1LM57_RAT

UniProt

F1LM57 - F1LM57_RAT

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Protein

DNA-directed RNA polymerase

Gene
Polr1b
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. ribonucleoside binding Source: InterPro

GO - Biological processi

  1. embryo development Source: Ensembl
  2. embryo implantation Source: Ensembl
  3. nucleologenesis Source: Ensembl
  4. rRNA transcription Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiREACT_206206. RNA Polymerase I Transcription Initiation.
REACT_218876. RNA Polymerase I Promoter Escape.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:Polr1bImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi620822. Polr1b.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. DNA-directed RNA polymerase I complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiF1LM57.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00750000117589.
OMAiEVFAGVT.
OrthoDBiEOG77M8MW.

Family and domain databases

Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LM57-1 [UniParc]FASTAAdd to Basket

« Hide

MDVDSRWRNL PSGPSLKHLT DPSYAVPPEQ QKAALQDLTR AHVDSFNYAV     50
LEGLSHAVQA IPPFEFAFKD ERISLTIVDA AISPPAVPKG TICKELNIYP 100
AECRGRRSTY RGKLTADISW AVNGVPKGII KQFLGYVPIM VKSKLCNLYN 150
LPPQVLIEHH EEAEEMGGYF IINGIEKVIR MLIMPRRNFP IAMIRPKWKS 200
RGLGYTQFGV SIHCVREEHS AVNMNLHYVE NGTVMLNFIY RKELFFLPLG 250
FALKALVSFS DYQIFQELIK GKEEDSFFKN SVSQMLRIVM EEGCHTQKQV 300
LDYLGERFRV KLSLPDWYPN AEAAEFLFNQ CICIHLKSNT DKFYLLCLMT 350
RKLFALARGE CMEDNPDSLV NQEVLTPGQL FLMFLKEKME NWLLSIKIAL 400
DKRAQKTNVS INNENLMKIF SMGTELTRPF EYLLATGNLR SKTGLGFMQD 450
SGLCVVADKL NFIRYLSHFR CVHRGADFAK MRTTTVRKLL PESWGFLCPV 500
HTPDGAPCGL LNHLTAVCEV VTKFVYTASI PALLCGLGVT PVDAAPCRPY 550
SDCYPVLLDG VMVGWVDKEL APEVADTLRR FKVLRERRSS LDGGGPDSHD 600
RKAKPVPRAV PLHHSLQAGE ACAEPGAGQR RARWNYGAAL HEHCHLRGRG 650
FWWSFHTPGA LPSQPAEVIA NFIPFSDHNQ SPRNMYQCQM GKQTMGFPLL 700
TYQDRSDNKL YRLQTPQSPL VRPCMYDHYD MDNYPIGTNA IVAVISYTGY 750
DMEDAMIVNK ASWERGFAHG SVYKSEFIDL SEKFKQGDDS LVFGVKPGDP 800
RVMQKLDNDG LPFIGAKLEF GDPYYGYLNL NTGEGFVVYY KSKENCVVDN 850
IKVCSNDTGS GKFKCVCVTV RVPRNPTIGD KFASRHGQKG ILSRLWPAED 900
MPFTESGMMP DILFNPHGFP SRMTIGMLIE SMAGKSAALH GLCHDATPFI 950
FSEENSALEY FGEMLKAAGY NFYGTERLYS GISGMELEAD IFIGVVYYQR 1000
LRHMVSDKFQ VRTTGARDKV TNQPIGGRNV QGGIRFGEME RDALLAHGTS 1050
FLLHDRLFNC SDRSVAHVCV KCGSLLSPLL EKPPPSWSAM RNRKYNCTVC 1100
GRSDSIDTVS VPYVFRYFVA ELAAMNIKVK LDVI 1134
Length:1,134
Mass (Da):127,669
Last modified:May 3, 2011 - v1
Checksum:i39DD5A8D6D58A6C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06026125 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000024882; ENSRNOP00000024882; ENSRNOG00000018349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06026125 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1LM57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024882 ; ENSRNOP00000024882 ; ENSRNOG00000018349 .

Organism-specific databases

RGDi 620822. Polr1b.

Phylogenomic databases

GeneTreei ENSGT00750000117589.
OMAi EVFAGVT.
OrthoDBi EOG77M8MW.

Enzyme and pathway databases

Reactomei REACT_206206. RNA Polymerase I Transcription Initiation.
REACT_218876. RNA Polymerase I Promoter Escape.

Miscellaneous databases

NextBioi 35575404.

Family and domain databases

Gene3Di 2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProi IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view ]
PANTHERi PTHR20856. PTHR20856. 1 hit.
Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view ]
PROSITEi PS01166. RNA_POL_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LM57_RAT
AccessioniPrimary (citable) accession number: F1LM57
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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