F1LM57 (F1LM57_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase RuleBase RU000431
EC=2.7.7.6 RuleBase RU000431

Gene names

Name:

Polr1b Ensembl ENSRNOP00000024882 RGD 620822

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000024882

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1134 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). RuleBase RU000431
Sequence similarities	Belongs to the RNA polymerase beta chain family. RuleBase RU000434
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000024882

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase RuleBase RU000431
Molecular function	Nucleotidyltransferase RuleBase RU000431 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryo development Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara nucleologenesis Inferred from electronic annotation. Source: Compara rRNA transcription Inferred from electronic annotation. Source: Compara
Cellular_component	DNA-directed RNA polymerase I complex Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F1LM57 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 39DD5A8D6D58A6C3	FASTA	1,134	127,669
	10 20 30 40 50 60 MDVDSRWRNL PSGPSLKHLT DPSYAVPPEQ QKAALQDLTR AHVDSFNYAV LEGLSHAVQA 70 80 90 100 110 120 IPPFEFAFKD ERISLTIVDA AISPPAVPKG TICKELNIYP AECRGRRSTY RGKLTADISW 130 140 150 160 170 180 AVNGVPKGII KQFLGYVPIM VKSKLCNLYN LPPQVLIEHH EEAEEMGGYF IINGIEKVIR 190 200 210 220 230 240 MLIMPRRNFP IAMIRPKWKS RGLGYTQFGV SIHCVREEHS AVNMNLHYVE NGTVMLNFIY 250 260 270 280 290 300 RKELFFLPLG FALKALVSFS DYQIFQELIK GKEEDSFFKN SVSQMLRIVM EEGCHTQKQV 310 320 330 340 350 360 LDYLGERFRV KLSLPDWYPN AEAAEFLFNQ CICIHLKSNT DKFYLLCLMT RKLFALARGE 370 380 390 400 410 420 CMEDNPDSLV NQEVLTPGQL FLMFLKEKME NWLLSIKIAL DKRAQKTNVS INNENLMKIF 430 440 450 460 470 480 SMGTELTRPF EYLLATGNLR SKTGLGFMQD SGLCVVADKL NFIRYLSHFR CVHRGADFAK 490 500 510 520 530 540 MRTTTVRKLL PESWGFLCPV HTPDGAPCGL LNHLTAVCEV VTKFVYTASI PALLCGLGVT 550 560 570 580 590 600 PVDAAPCRPY SDCYPVLLDG VMVGWVDKEL APEVADTLRR FKVLRERRSS LDGGGPDSHD 610 620 630 640 650 660 RKAKPVPRAV PLHHSLQAGE ACAEPGAGQR RARWNYGAAL HEHCHLRGRG FWWSFHTPGA 670 680 690 700 710 720 LPSQPAEVIA NFIPFSDHNQ SPRNMYQCQM GKQTMGFPLL TYQDRSDNKL YRLQTPQSPL 730 740 750 760 770 780 VRPCMYDHYD MDNYPIGTNA IVAVISYTGY DMEDAMIVNK ASWERGFAHG SVYKSEFIDL 790 800 810 820 830 840 SEKFKQGDDS LVFGVKPGDP RVMQKLDNDG LPFIGAKLEF GDPYYGYLNL NTGEGFVVYY 850 860 870 880 890 900 KSKENCVVDN IKVCSNDTGS GKFKCVCVTV RVPRNPTIGD KFASRHGQKG ILSRLWPAED 910 920 930 940 950 960 MPFTESGMMP DILFNPHGFP SRMTIGMLIE SMAGKSAALH GLCHDATPFI FSEENSALEY 970 980 990 1000 1010 1020 FGEMLKAAGY NFYGTERLYS GISGMELEAD IFIGVVYYQR LRHMVSDKFQ VRTTGARDKV 1030 1040 1050 1060 1070 1080 TNQPIGGRNV QGGIRFGEME RDALLAHGTS FLLHDRLFNC SDRSVAHVCV KCGSLLSPLL 1090 1100 1110 1120 1130 EKPPPSWSAM RNRKYNCTVC GRSDSIDTVS VPYVFRYFVA ELAAMNIKVK LDVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000024882.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000024882.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06026125 Genomic DNA. No translation available.
IPI	IPI00231082.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000024882; ENSRNOP00000024882; ENSRNOG00000018349.
Organism-specific databases
RGD	620822. Polr1b.
Phylogenomic databases
GeneTree	ENSGT00550000074993.
Gene expression databases
ArrayExpress	F1LM57.
Family and domain databases
Gene3D	2.40.270.10. 2 hits. 2.40.50.150. 1 hit.
InterPro	IPR015712. DNA-dir_RNA_pol_su2. IPR007120. DNA-dir_RNA_pol_su2_6. IPR007121. RNA_pol_bsu_CS. IPR007644. RNA_pol_bsu_protrusion. IPR007642. RNA_pol_Rpb2_2. IPR007645. RNA_pol_Rpb2_3. IPR007641. RNA_pol_Rpb2_7. IPR014724. RNA_pol_RPB2_OB-fold. [Graphical view]
PANTHER	PTHR20856. PTHR20856. 1 hit.
Pfam	PF04563. RNA_pol_Rpb2_1. 1 hit. PF04561. RNA_pol_Rpb2_2. 1 hit. PF04565. RNA_pol_Rpb2_3. 1 hit. PF00562. RNA_pol_Rpb2_6. 1 hit. PF04560. RNA_pol_Rpb2_7. 1 hit. [Graphical view]
PROSITE	PS01166. RNA_POL_BETA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35575404.

Entry information

Entry name

F1LM57_RAT

Accession

Primary (citable) accession number: F1LM57

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)