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F1LM57

- F1LM57_RAT

UniProt

F1LM57 - F1LM57_RAT

Protein

DNA-directed RNA polymerase

Gene

Polr1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    3. ribonucleoside binding Source: InterPro

    GO - Biological processi

    1. embryo development Source: Ensembl
    2. embryo implantation Source: Ensembl
    3. nucleologenesis Source: Ensembl
    4. rRNA transcription Source: Ensembl

    Keywords - Molecular functioni

    NucleotidyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    ReactomeiREACT_206206. RNA Polymerase I Transcription Initiation.
    REACT_218876. RNA Polymerase I Promoter Escape.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.6UniRule annotation)
    Gene namesi
    Name:Polr1bImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi620822. Polr1b.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. DNA-directed RNA polymerase I complex Source: Ensembl

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiF1LM57.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00750000117589.
    OMAiEVFAGVT.
    OrthoDBiEOG77M8MW.

    Family and domain databases

    Gene3Di2.40.270.10. 2 hits.
    2.40.50.150. 1 hit.
    3.90.1110.10. 1 hit.
    InterProiIPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view]
    PANTHERiPTHR20856. PTHR20856. 1 hit.
    PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04561. RNA_pol_Rpb2_2. 1 hit.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view]
    PROSITEiPS01166. RNA_POL_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LM57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVDSRWRNL PSGPSLKHLT DPSYAVPPEQ QKAALQDLTR AHVDSFNYAV     50
    LEGLSHAVQA IPPFEFAFKD ERISLTIVDA AISPPAVPKG TICKELNIYP 100
    AECRGRRSTY RGKLTADISW AVNGVPKGII KQFLGYVPIM VKSKLCNLYN 150
    LPPQVLIEHH EEAEEMGGYF IINGIEKVIR MLIMPRRNFP IAMIRPKWKS 200
    RGLGYTQFGV SIHCVREEHS AVNMNLHYVE NGTVMLNFIY RKELFFLPLG 250
    FALKALVSFS DYQIFQELIK GKEEDSFFKN SVSQMLRIVM EEGCHTQKQV 300
    LDYLGERFRV KLSLPDWYPN AEAAEFLFNQ CICIHLKSNT DKFYLLCLMT 350
    RKLFALARGE CMEDNPDSLV NQEVLTPGQL FLMFLKEKME NWLLSIKIAL 400
    DKRAQKTNVS INNENLMKIF SMGTELTRPF EYLLATGNLR SKTGLGFMQD 450
    SGLCVVADKL NFIRYLSHFR CVHRGADFAK MRTTTVRKLL PESWGFLCPV 500
    HTPDGAPCGL LNHLTAVCEV VTKFVYTASI PALLCGLGVT PVDAAPCRPY 550
    SDCYPVLLDG VMVGWVDKEL APEVADTLRR FKVLRERRSS LDGGGPDSHD 600
    RKAKPVPRAV PLHHSLQAGE ACAEPGAGQR RARWNYGAAL HEHCHLRGRG 650
    FWWSFHTPGA LPSQPAEVIA NFIPFSDHNQ SPRNMYQCQM GKQTMGFPLL 700
    TYQDRSDNKL YRLQTPQSPL VRPCMYDHYD MDNYPIGTNA IVAVISYTGY 750
    DMEDAMIVNK ASWERGFAHG SVYKSEFIDL SEKFKQGDDS LVFGVKPGDP 800
    RVMQKLDNDG LPFIGAKLEF GDPYYGYLNL NTGEGFVVYY KSKENCVVDN 850
    IKVCSNDTGS GKFKCVCVTV RVPRNPTIGD KFASRHGQKG ILSRLWPAED 900
    MPFTESGMMP DILFNPHGFP SRMTIGMLIE SMAGKSAALH GLCHDATPFI 950
    FSEENSALEY FGEMLKAAGY NFYGTERLYS GISGMELEAD IFIGVVYYQR 1000
    LRHMVSDKFQ VRTTGARDKV TNQPIGGRNV QGGIRFGEME RDALLAHGTS 1050
    FLLHDRLFNC SDRSVAHVCV KCGSLLSPLL EKPPPSWSAM RNRKYNCTVC 1100
    GRSDSIDTVS VPYVFRYFVA ELAAMNIKVK LDVI 1134
    Length:1,134
    Mass (Da):127,669
    Last modified:May 3, 2011 - v1
    Checksum:i39DD5A8D6D58A6C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06026125 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000024882; ENSRNOP00000024882; ENSRNOG00000018349.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06026125 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1LM57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024882 ; ENSRNOP00000024882 ; ENSRNOG00000018349 .

    Organism-specific databases

    RGDi 620822. Polr1b.

    Phylogenomic databases

    GeneTreei ENSGT00750000117589.
    OMAi EVFAGVT.
    OrthoDBi EOG77M8MW.

    Enzyme and pathway databases

    Reactomei REACT_206206. RNA Polymerase I Transcription Initiation.
    REACT_218876. RNA Polymerase I Promoter Escape.

    Miscellaneous databases

    NextBioi 35575404.

    Family and domain databases

    Gene3Di 2.40.270.10. 2 hits.
    2.40.50.150. 1 hit.
    3.90.1110.10. 1 hit.
    InterProi IPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view ]
    PANTHERi PTHR20856. PTHR20856. 1 hit.
    Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04561. RNA_pol_Rpb2_2. 1 hit.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view ]
    PROSITEi PS01166. RNA_POL_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LM57_RAT
    AccessioniPrimary (citable) accession number: F1LM57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3