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Protein
Submitted name:

Ras-specific guanine nucleotide-releasing factor 1

Gene

Rasgrf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. activation of Rac GTPase activity Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. neuron projection development Source: Ensembl
  4. regulation of neuronal synaptic plasticity Source: Ensembl
  5. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
  6. regulation of Rac protein signal transduction Source: Ensembl
  7. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_196389. Ras activation uopn Ca2+ infux through NMDA receptor.

Names & Taxonomyi

Protein namesi
Submitted name:
Ras-specific guanine nucleotide-releasing factor 1Imported
Gene namesi
Name:Rasgrf1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi620395. Rasgrf1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. growth cone Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF1LM43.

Expressioni

Gene expression databases

ExpressionAtlasiF1LM43. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Contains 2 PH domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation
Contains N-terminal Ras-GEF domain.SAAS annotation
Contains Ras-GEF domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121844.
OMAiKNSSEFP.
OrthoDBiEOG7H1JKP.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00169. PH. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LM43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKAIRLNDG HVVSLGLLAQ RDGTRKGYLS KRSSDNPKWQ TKWFALLQNL
60 70 80 90 100
LFYFESDSSS HQEGLMWMEA SLPSRGPTPK TRGAKGHSAV QHHYFTVNFS
110 120 130 140 150
NDSQKSLELR TDDSKDCDEW VAAIARASYK ILATEHEALM QKYLHLLQVV
160 170 180 190 200
ETEKTVAKQL RQQLEDGEVE IERLKAEIAN LIKDNERIQS NQLVAPEDED
210 220 230 240 250
SDIKKIKKVQ SFLRGWLCRR KWKNIIQDYI RSPHADSMRK RNQVVFSMLE
260 270 280 290 300
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
310 320 330 340 350
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC
360 370 380 390 400
KQNRDFDKLL KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP
410 420 430 440 450
HEHVERNSLD YAKSKLEELS RVMHDEVSET ENIRKNLAIE RMITEGCEIL
460 470 480 490 500
LDTSQTFVRQ GSLIQVPMSE KGKINKGRLG SLSLKKEGER QCFLFSKHLI
510 520 530 540 550
ICTRGSGSKL HLTKNGVISL IDCTLLDDPE NMDDDGKGKG QEVDHLDFKI
560 570 580 590 600
WVEPKDSPPF TVILVASSRQ EKAAWTSDII QCVDNIRCNG LMMNAFEENS
610 620 630 640 650
KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL
660 670 680 690 700
RFLSIDFLNT FLHSYRVFTD AVVVLDKLIS IYKKPITAIP ARSLELLFSS
710 720 730 740 750
SHNTKLLYGD APKSPRASRK FSSPPPLAIG TSSPVRRRKL SLNIPIITGG
760 770 780 790 800
KALELASLGC PSDGYTNIHS PISPFGKTTL DTSKLCVASS LTRTPEEIDM
810 820 830 840 850
TTLEESSGFR KPTSDILKEE SDDDQSDVDD TEVSPPTPKS FRNRITQEFP
860 870 880 890 900
LFNYNSGIMM TCRDLMDSNR SPLSATSAFA IATAGANESP ANKEIYRRMS
910 920 930 940 950
LANTGYSSDQ RNIDKEFVIR RAATNRVLNV LRHWVTKHSQ DFETDDLLKY
960 970 980 990 1000
KVICFLEEVM HDPDLLPQER KAAANIMRTL TQEEITENHS MLDELLLMTE
1010 1020 1030 1040 1050
GVKTEPFENH SAMEIAEQLT LLDHLVFKSI PYEEFFGQGW MKADKNERTP
1060 1070 1080 1090 1100
YIMKTTRHFN HISNLIASEI LRNEEVSARA STIEKWVAVA DICRCLHNYN
1110 1120 1130 1140 1150
AVLEITSSIN RSAIFRLKKT WLKVSKQTKS LFDKLQKLVS SDGRFKNLRE
1160 1170 1180 1190 1200
TLRNCDPPCV PYLGMYLTDL AFLEEGTPNY TEDGLVNFSK MRMISHIIRE
1210 1220 1230 1240
IRQFQQTTYK IEPQPKVTQY LVDETFVLDD ESLYEASLRI EPKLPT
Length:1,246
Mass (Da):142,761
Last modified:April 3, 2013 - v2
Checksum:i3A7EE5FED65F9B8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06056307 Genomic DNA. No translation available.
AABR06056308 Genomic DNA. No translation available.
AABR06056309 Genomic DNA. No translation available.
AABR06056310 Genomic DNA. No translation available.
AABR06056311 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06056307 Genomic DNA. No translation available.
AABR06056308 Genomic DNA. No translation available.
AABR06056309 Genomic DNA. No translation available.
AABR06056310 Genomic DNA. No translation available.
AABR06056311 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiF1LM43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025.

Organism-specific databases

RGDi620395. Rasgrf1.

Phylogenomic databases

GeneTreeiENSGT00780000121844.
OMAiKNSSEFP.
OrthoDBiEOG7H1JKP.

Enzyme and pathway databases

ReactomeiREACT_196389. Ras activation uopn Ca2+ infux through NMDA receptor.

Miscellaneous databases

NextBioi35575394.

Gene expression databases

ExpressionAtlasiF1LM43. baseline and differential.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00169. PH. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LM43_RAT
AccessioniPrimary (citable) accession number: F1LM43
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: March 4, 2015
This is version 35 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.