SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

F1LM43

- F1LM43_RAT

UniProt

F1LM43 - F1LM43_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Ras-specific guanine nucleotide-releasing factor 1
Gene
Rasgrf1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. activation of Rac GTPase activity Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. neuron projection development Source: Ensembl
  4. regulation of Rac protein signal transduction Source: Ensembl
  5. regulation of neuronal synaptic plasticity Source: Ensembl
  6. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Ras-specific guanine nucleotide-releasing factor 1Imported
Gene namesi
Name:Rasgrf1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi620395. Rasgrf1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. growth cone Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF1LM43.

Family & Domainsi

Sequence similaritiesi

Contains 2 PH domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotations
Contains N-terminal Ras-GEF domain.SAAS annotations
Contains Ras-GEF domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110221.
OMAiSMYSAMS.
OrthoDBiEOG7H1JKP.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00169. PH. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LM43-1 [UniParc]FASTAAdd to Basket

« Hide

MQKAIRLNDG HVVSLGLLAQ RDGTRKGYLS KRSSDNPKWQ TKWFALLQNL     50
LFYFESDSSS HQEGLMWMEA SLPSRGPTPK TRGAKGHSAV QHHYFTVNFS 100
NDSQKSLELR TDDSKDCDEW VAAIARASYK ILATEHEALM QKYLHLLQVV 150
ETEKTVAKQL RQQLEDGEVE IERLKAEIAN LIKDNERIQS NQLVAPEDED 200
SDIKKIKKVQ SFLRGWLCRR KWKNIIQDYI RSPHADSMRK RNQVVFSMLE 250
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 300
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 350
KQNRDFDKLL KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 400
HEHVERNSLD YAKSKLEELS RVMHDEVSET ENIRKNLAIE RMITEGCEIL 450
LDTSQTFVRQ GSLIQVPMSE KGKINKGRLG SLSLKKEGER QCFLFSKHLI 500
ICTRGSGSKL HLTKNGVISL IDCTLLDDPE NMDDDGKGKG QEVDHLDFKI 550
WVEPKDSPPF TVILVASSRQ EKAAWTSDII QCVDNIRCNG LMMNAFEENS 600
KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL 650
RFLSIDFLNT FLHSYRVFTD AVVVLDKLIS IYKKPITAIP ARSLELLFSS 700
SHNTKLLYGD APKSPRASRK FSSPPPLAIG TSSPVRRRKL SLNIPIITGG 750
KALELASLGC PSDGYTNIHS PISPFGKTTL DTSKLCVASS LTRTPEEIDM 800
TTLEESSGFR KPTSDILKEE SDDDQSDVDD TEVSPPTPKS FRNRITQEFP 850
LFNYNSGIMM TCRDLMDSNR SPLSATSAFA IATAGANESP ANKEIYRRMS 900
LANTGYSSDQ RNIDKEFVIR RAATNRVLNV LRHWVTKHSQ DFETDDLLKY 950
KVICFLEEVM HDPDLLPQER KAAANIMRTL TQEEITENHS MLDELLLMTE 1000
GVKTEPFENH SAMEIAEQLT LLDHLVFKSI PYEEFFGQGW MKADKNERTP 1050
YIMKTTRHFN HISNLIASEI LRNEEVSARA STIEKWVAVA DICRCLHNYN 1100
AVLEITSSIN RSAIFRLKKT WLKVSKQTKS LFDKLQKLVS SDGRFKNLRE 1150
TLRNCDPPCV PYLGMYLTDL AFLEEGTPNY TEDGLVNFSK MRMISHIIRE 1200
IRQFQQTTYK IEPQPKVTQY LVDETFVLDD ESLYEASLRI EPKLPT 1246
Length:1,246
Mass (Da):142,761
Last modified:April 3, 2013 - v2
Checksum:i3A7EE5FED65F9B8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06056307 Genomic DNA. No translation available.
AABR06056308 Genomic DNA. No translation available.
AABR06056309 Genomic DNA. No translation available.
AABR06056310 Genomic DNA. No translation available.
AABR06056311 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06056307 Genomic DNA. No translation available.
AABR06056308 Genomic DNA. No translation available.
AABR06056309 Genomic DNA. No translation available.
AABR06056310 Genomic DNA. No translation available.
AABR06056311 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1LM43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018794 ; ENSRNOP00000018794 ; ENSRNOG00000014025 .

Organism-specific databases

RGDi 620395. Rasgrf1.

Phylogenomic databases

GeneTreei ENSGT00730000110221.
OMAi SMYSAMS.
OrthoDBi EOG7H1JKP.

Miscellaneous databases

NextBioi 35575394.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProi IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00169. PH. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEi PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LM43_RAT
AccessioniPrimary (citable) accession number: F1LM43
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: September 3, 2014
This is version 29 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi