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F1LM43 (F1LM43_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Ras-specific guanine nucleotide-releasing factor 1 Ensembl ENSRNOP00000018794
Gene names
Name:Rasgrf1 Ensembl ENSRNOP00000018794
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000018794
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length1246 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS001331

Contains 1 N-terminal Ras-GEF domain. SAAS SAAS000651

Contains 1 Ras-GEF domain. SAAS SAAS000651

Contains 2 PH domains. RuleBase RU003350

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000018794

Sequences

Sequence LengthMass (Da)Tools
F1LM43 [UniParc].

Last modified April 3, 2013. Version 2.
Checksum: 3A7EE5FED65F9B8B

FASTA1,246142,761
        10         20         30         40         50         60 
MQKAIRLNDG HVVSLGLLAQ RDGTRKGYLS KRSSDNPKWQ TKWFALLQNL LFYFESDSSS 

        70         80         90        100        110        120 
HQEGLMWMEA SLPSRGPTPK TRGAKGHSAV QHHYFTVNFS NDSQKSLELR TDDSKDCDEW 

       130        140        150        160        170        180 
VAAIARASYK ILATEHEALM QKYLHLLQVV ETEKTVAKQL RQQLEDGEVE IERLKAEIAN 

       190        200        210        220        230        240 
LIKDNERIQS NQLVAPEDED SDIKKIKKVQ SFLRGWLCRR KWKNIIQDYI RSPHADSMRK 

       250        260        270        280        290        300 
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 

       310        320        330        340        350        360 
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL 

       370        380        390        400        410        420 
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS 

       430        440        450        460        470        480 
RVMHDEVSET ENIRKNLAIE RMITEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKINKGRLG 

       490        500        510        520        530        540 
SLSLKKEGER QCFLFSKHLI ICTRGSGSKL HLTKNGVISL IDCTLLDDPE NMDDDGKGKG 

       550        560        570        580        590        600 
QEVDHLDFKI WVEPKDSPPF TVILVASSRQ EKAAWTSDII QCVDNIRCNG LMMNAFEENS 

       610        620        630        640        650        660 
KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL RFLSIDFLNT 

       670        680        690        700        710        720 
FLHSYRVFTD AVVVLDKLIS IYKKPITAIP ARSLELLFSS SHNTKLLYGD APKSPRASRK 

       730        740        750        760        770        780 
FSSPPPLAIG TSSPVRRRKL SLNIPIITGG KALELASLGC PSDGYTNIHS PISPFGKTTL 

       790        800        810        820        830        840 
DTSKLCVASS LTRTPEEIDM TTLEESSGFR KPTSDILKEE SDDDQSDVDD TEVSPPTPKS 

       850        860        870        880        890        900 
FRNRITQEFP LFNYNSGIMM TCRDLMDSNR SPLSATSAFA IATAGANESP ANKEIYRRMS 

       910        920        930        940        950        960 
LANTGYSSDQ RNIDKEFVIR RAATNRVLNV LRHWVTKHSQ DFETDDLLKY KVICFLEEVM 

       970        980        990       1000       1010       1020 
HDPDLLPQER KAAANIMRTL TQEEITENHS MLDELLLMTE GVKTEPFENH SAMEIAEQLT 

      1030       1040       1050       1060       1070       1080 
LLDHLVFKSI PYEEFFGQGW MKADKNERTP YIMKTTRHFN HISNLIASEI LRNEEVSARA 

      1090       1100       1110       1120       1130       1140 
STIEKWVAVA DICRCLHNYN AVLEITSSIN RSAIFRLKKT WLKVSKQTKS LFDKLQKLVS 

      1150       1160       1170       1180       1190       1200 
SDGRFKNLRE TLRNCDPPCV PYLGMYLTDL AFLEEGTPNY TEDGLVNFSK MRMISHIIRE 

      1210       1220       1230       1240 
IRQFQQTTYK IEPQPKVTQY LVDETFVLDD ESLYEASLRI EPKLPT

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000018794.
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000018794.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AABR06056307 Genomic DNA. No translation available.
AABR06056308 Genomic DNA. No translation available.
AABR06056309 Genomic DNA. No translation available.
AABR06056310 Genomic DNA. No translation available.
AABR06056311 Genomic DNA. No translation available.
IPIIPI00204771.

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEF1LM43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025.

Organism-specific databases

RGD620395. Rasgrf1.

Phylogenomic databases

GeneTreeENSGT00700000104175.

Gene expression databases

ArrayExpressF1LM43.

Family and domain databases

Gene3D1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR008937. Ras_GEF.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PANTHERPTHR23113. PTHR23113. 1 hit.
PfamPF00169. PH. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTSM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMSSF48065. DH-domain. 1 hit.
SSF48366. Ras_GEF. 1 hit.
PROSITEPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35575394.

Entry information

Entry nameF1LM43_RAT
AccessionPrimary (citable) accession number: F1LM43
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: May 1, 2013
This is version 20 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info