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Protein
Submitted name:

Ras-specific guanine nucleotide-releasing factor 1

Gene

Rasgrf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-RNO-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Ras-specific guanine nucleotide-releasing factor 1Imported
Gene namesi
Name:Rasgrf1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620395. Rasgrf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiF1LM43.
PRIDEiF1LM43.

Expressioni

Gene expression databases

ExpressionAtlasiF1LM43. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018794.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 129108PHInterPro annotationAdd
BLAST
Domaini240 – 426187DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini456 – 584129PHInterPro annotationAdd
BLAST
Domaini631 – 745115N-terminal Ras-GEFInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili150 – 19142Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 PH domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation
Contains N-terminal Ras-GEF domain.SAAS annotation
Contains Ras-GEF domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IQ6Q. Eukaryota.
ENOG410XPWA. LUCA.
OMAiDNDQNQS.
OrthoDBiEOG7H1JKP.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030745. RasGRF1.
[Graphical view]
PANTHERiPTHR23113:SF193. PTHR23113:SF193. 3 hits.
PfamiPF00169. PH. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF50729. SSF50729. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LM43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVGILVTG GVCVFFSVQH HYFTVNFSND SQKSLELRTD DSKDCDEWVA
60 70 80 90 100
AIARASYKIL ATEHEALMQK YLHLLQVVET EKTVAKQLRQ QLEDGEVEIE
110 120 130 140 150
RLKAEIANLI KDNERIQSNQ LVAPEDEDSD IKKIKKVQSF LRGWLCRRKW
160 170 180 190 200
KNIIQDYIRS PHADSMRKRN QVVFSMLEAE AEYVQQLHIL VNNFLRPLRM
210 220 230 240 250
AASSKKPPIT HDDVSSIFLN SETIMFLHQI FYQGLKARIA SWPTLVLADL
260 270 280 290 300
FDILLPMLNI YQEFVRNHQY SLQILAHCKQ NRDFDKLLKQ YEAKPDCEER
310 320 330 340 350
TLETFLTYPM FQIPRYILTL HELLAHTPHE HVERNSLDYA KSKLEELSRV
360 370 380 390 400
MHDEVSETEN IRKNLAIERM ITEGCEILLD TSQTFVRQGS LIQVPMSEKG
410 420 430 440 450
KINKGRLGSL SLKKEGERQC FLFSKHLIIC TRGSGSKLHL TKNGVISLID
460 470 480 490 500
CTLLDDPENM DDDGKGQEVD HLDFKIWVEP KDSPPFTVIL VASSRQEKAA
510 520 530 540 550
WTSDIIQCVD NIRCNGLMMN AFEENSKVTV PQMIKSDASL YCDDVDIRFS
560 570 580 590 600
KTMNSCKVLQ IRYASVERLL ERLTDLRFLS IDFLNTFLHS YRVFTDAVVV
610 620 630 640 650
LDKLISIYKK PITAIPARSL ELLFSSSHNT KLLYGDAPKS PRASRKFSSP
660 670 680 690 700
PPLAIGTSSP VRRRKLSLNI PIITGGKALE LASLGCPSDG YTNIHSPISP
710 720 730 740 750
FGKTTLDTSK LCVASSLTRT PEEIDMTTLE ESSGFRKPTS DILKEESDDD
760 770 780 790 800
QSDVDDTEVS PPTPKSFRNR ITQEFPLFNY NSGIMMTCRD LMDSNRSPLS
810 820 830 840 850
ATSAFAIATA GANESPANKE IYRRMSLANT GYSSDQRNID KEFVIRRAAT
860 870 880 890 900
NRVLNVLRHW VTKHSQDFET DDLLKYKVIC FLEEVMHDPD LLPQERKAAA
910 920 930 940 950
NIMRTLTQEE ITENHSMLDE LLLMTEGVKT EPFENHSAME IAEQLTLLDH
960 970 980 990 1000
LVFKSIPYEE FFGQGWMKAD KNERTPYIMK TTRHFNHISN LIASEILRNE
1010 1020 1030 1040 1050
EVSARASTIE KWVAVADICR CLHNYNAVLE ITSSINRSAI FRLKKTWLKV
1060 1070 1080 1090 1100
SKQTKSLFDK LQKLVSSDGR FKNLRETLRN CDPPCVPYLG MYLTDLAFLE
1110 1120 1130 1140 1150
EGTPNYTEDG LVNFSKMRMI SHIIREIRQF QQTTYKIEPQ PKVTQYLVDE
1160 1170
TFVLDDESLY EASLRIEPKL PT
Length:1,172
Mass (Da):134,261
Last modified:May 11, 2016 - v3
Checksum:i0769C11A04ABA423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071024 Genomic DNA. No translation available.
AABR07071025 Genomic DNA. No translation available.
AABR07071026 Genomic DNA. No translation available.
AABR07071027 Genomic DNA. No translation available.
AABR07071028 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071024 Genomic DNA. No translation available.
AABR07071025 Genomic DNA. No translation available.
AABR07071026 Genomic DNA. No translation available.
AABR07071027 Genomic DNA. No translation available.
AABR07071028 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018794.

Proteomic databases

PaxDbiF1LM43.
PRIDEiF1LM43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025.

Organism-specific databases

RGDi620395. Rasgrf1.

Phylogenomic databases

eggNOGiENOG410IQ6Q. Eukaryota.
ENOG410XPWA. LUCA.
OMAiDNDQNQS.
OrthoDBiEOG7H1JKP.

Enzyme and pathway databases

ReactomeiR-RNO-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-RNO-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

NextBioi35575394.

Gene expression databases

ExpressionAtlasiF1LM43. baseline and differential.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030745. RasGRF1.
[Graphical view]
PANTHERiPTHR23113:SF193. PTHR23113:SF193. 3 hits.
PfamiPF00169. PH. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF50729. SSF50729. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LM43_RAT
AccessioniPrimary (citable) accession number: F1LM43
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 11, 2016
Last modified: May 11, 2016
This is version 46 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.