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Protein
Submitted name:

Ras-specific guanine nucleotide-releasing factor 1

Gene

Rasgrf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-RNO-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Submitted name:
Ras-specific guanine nucleotide-releasing factor 1Imported
Gene namesi
Name:Rasgrf1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620395 Rasgrf1

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiF1LM43

Expressioni

Gene expression databases

BgeeiENSRNOG00000014025
ExpressionAtlasiF1LM43 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57PHInterPro annotationAdd BLAST57
Domaini168 – 354DHInterPro annotationAdd BLAST187
Domaini384 – 510PHInterPro annotationAdd BLAST127
Domaini557 – 671N-terminal Ras-GEFInterPro annotationAdd BLAST115
Domaini937 – 1169Ras-GEFInterPro annotationAdd BLAST233

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 119Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IQ6Q Eukaryota
ENOG410XPWA LUCA
GeneTreeiENSGT00910000143985

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.10.840.101 hit
1.20.900.101 hit
2.30.29.301 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR000048 IQ_motif_EF-hand-BS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR030745 RasGRF1
PANTHERiPTHR23113:SF193 PTHR23113:SF193, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48366 SSF48366, 2 hits
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

F1LM43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVGILVTG GVCVFFSVQH HYFTVNFSND SQKSLELRTD DSKDCDEWVA
60 70 80 90 100
AIARASYKIL ATEHEALMQK YLHLLQVVET EKTVAKQLRQ QLEDGEVEIE
110 120 130 140 150
RLKAEIANLI KDNERIQSNQ LVAPEDEDSD IKKIKKVQSF LRGWLCRRKW
160 170 180 190 200
KNIIQDYIRS PHADSMRKRN QVVFSMLEAE AEYVQQLHIL VNNFLRPLRM
210 220 230 240 250
AASSKKPPIT HDDVSSIFLN SETIMFLHQI FYQGLKARIA SWPTLVLADL
260 270 280 290 300
FDILLPMLNI YQEFVRNHQY SLQILAHCKQ NRDFDKLLKQ YEAKPDCEER
310 320 330 340 350
TLETFLTYPM FQIPRYILTL HELLAHTPHE HVERNSLDYA KSKLEELSRV
360 370 380 390 400
MHDEVSETEN IRKNLAIERM ITEGCEILLD TSQTFVRQGS LIQVPMSEKG
410 420 430 440 450
KINKGRLGSL SLKKEGERQC FLFSKHLIIC TRGSGSKLHL TKNGVISLID
460 470 480 490 500
CTLLDDPENM DDDGKGQEVD HLDFKIWVEP KDSPPFTVIL VASSRQEKAA
510 520 530 540 550
WTSDIIQCVD NIRCNGLMMN AFEENSKVTV PQMIKSDASL YCDDVDIRFS
560 570 580 590 600
KTMNSCKVLQ IRYASVERLL ERLTDLRFLS IDFLNTFLHS YRVFTDAVVV
610 620 630 640 650
LDKLISIYKK PITAIPARSL ELLFSSSHNT KLLYGDAPKS PRASRKFSSP
660 670 680 690 700
PPLAIGTSSP VRRRKLSLNI PIITGGKALE LASLGCPSDG YTNIHSPISP
710 720 730 740 750
FGKTTLDTSK LCVASSLTRT PEEIDMTTLE ESSGFRKPTS DILKEESDDD
760 770 780 790 800
QSDVDDTEVS PPTPKSFRNR ITQEFPLFNY NSGIMMTCRD LMDSNRSPLS
810 820 830 840 850
ATSAFAIATA GANESPANKE IYRRMSLANT GYSSDQRNID KEFVIRRAAT
860 870 880 890 900
NRVLNVLRHW VTKHSQDFET DDLLKYKVIC FLEEVMHDPD LLPQERKAAA
910 920 930 940 950
NIMRTLTQEE ITENHSMLDE LLLMTEGVKT EPFENHSAME IAEQLTLLDH
960 970 980 990 1000
LVFKSIPYEE FFGQGWMKAD KNERTPYIMK TTRHFNHISN LIASEILRNE
1010 1020 1030 1040 1050
EVSARASTIE KWVAVADICR CLHNYNAVLE ITSSINRSAI FRLKKTWLKV
1060 1070 1080 1090 1100
SKQTKSLFDK LQKLVSSDGR FKNLRETLRN CDPPCVPYLG MYLTDLAFLE
1110 1120 1130 1140 1150
EGTPNYTEDG LVNFSKMRMI SHIIREIRQF QQTTYKIEPQ PKVTQYLVDE
1160 1170
TFVLDDESLY EASLRIEPKL PT
Length:1,172
Mass (Da):134,261
Last modified:May 11, 2016 - v3
Checksum:i0769C11A04ABA423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071024 Genomic DNA No translation available.
AABR07071025 Genomic DNA No translation available.
AABR07071026 Genomic DNA No translation available.
AABR07071027 Genomic DNA No translation available.
AABR07071028 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025

Similar proteinsi

Entry informationi

Entry nameiF1LM43_RAT
AccessioniPrimary (citable) accession number: F1LM43
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 11, 2016
Last modified: April 25, 2018
This is version 64 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported