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F1LM43

- F1LM43_RAT

UniProt

F1LM43 - F1LM43_RAT

Protein
Submitted name:

Ras-specific guanine nucleotide-releasing factor 1

Gene

Rasgrf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. activation of Rac GTPase activity Source: Ensembl
    2. cell proliferation Source: Ensembl
    3. neuron projection development Source: Ensembl
    4. regulation of neuronal synaptic plasticity Source: Ensembl
    5. regulation of Rac protein signal transduction Source: Ensembl
    6. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factorSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ras-specific guanine nucleotide-releasing factor 1Imported
    Gene namesi
    Name:Rasgrf1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi620395. Rasgrf1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. growth cone Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiF1LM43.

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 PH domains.UniRule annotation
    Contains DH (DBL-homology) domain.SAAS annotation
    Contains N-terminal Ras-GEF domain.SAAS annotation
    Contains Ras-GEF domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110221.
    OMAiSMYSAMS.
    OrthoDBiEOG7H1JKP.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    InterProiIPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00169. PH. 2 hits.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00015. IQ. 1 hit.
    SM00233. PH. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 2 hits.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF48366. SSF48366. 2 hits.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50096. IQ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LM43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKAIRLNDG HVVSLGLLAQ RDGTRKGYLS KRSSDNPKWQ TKWFALLQNL     50
    LFYFESDSSS HQEGLMWMEA SLPSRGPTPK TRGAKGHSAV QHHYFTVNFS 100
    NDSQKSLELR TDDSKDCDEW VAAIARASYK ILATEHEALM QKYLHLLQVV 150
    ETEKTVAKQL RQQLEDGEVE IERLKAEIAN LIKDNERIQS NQLVAPEDED 200
    SDIKKIKKVQ SFLRGWLCRR KWKNIIQDYI RSPHADSMRK RNQVVFSMLE 250
    AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 300
    QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 350
    KQNRDFDKLL KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 400
    HEHVERNSLD YAKSKLEELS RVMHDEVSET ENIRKNLAIE RMITEGCEIL 450
    LDTSQTFVRQ GSLIQVPMSE KGKINKGRLG SLSLKKEGER QCFLFSKHLI 500
    ICTRGSGSKL HLTKNGVISL IDCTLLDDPE NMDDDGKGKG QEVDHLDFKI 550
    WVEPKDSPPF TVILVASSRQ EKAAWTSDII QCVDNIRCNG LMMNAFEENS 600
    KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL 650
    RFLSIDFLNT FLHSYRVFTD AVVVLDKLIS IYKKPITAIP ARSLELLFSS 700
    SHNTKLLYGD APKSPRASRK FSSPPPLAIG TSSPVRRRKL SLNIPIITGG 750
    KALELASLGC PSDGYTNIHS PISPFGKTTL DTSKLCVASS LTRTPEEIDM 800
    TTLEESSGFR KPTSDILKEE SDDDQSDVDD TEVSPPTPKS FRNRITQEFP 850
    LFNYNSGIMM TCRDLMDSNR SPLSATSAFA IATAGANESP ANKEIYRRMS 900
    LANTGYSSDQ RNIDKEFVIR RAATNRVLNV LRHWVTKHSQ DFETDDLLKY 950
    KVICFLEEVM HDPDLLPQER KAAANIMRTL TQEEITENHS MLDELLLMTE 1000
    GVKTEPFENH SAMEIAEQLT LLDHLVFKSI PYEEFFGQGW MKADKNERTP 1050
    YIMKTTRHFN HISNLIASEI LRNEEVSARA STIEKWVAVA DICRCLHNYN 1100
    AVLEITSSIN RSAIFRLKKT WLKVSKQTKS LFDKLQKLVS SDGRFKNLRE 1150
    TLRNCDPPCV PYLGMYLTDL AFLEEGTPNY TEDGLVNFSK MRMISHIIRE 1200
    IRQFQQTTYK IEPQPKVTQY LVDETFVLDD ESLYEASLRI EPKLPT 1246
    Length:1,246
    Mass (Da):142,761
    Last modified:April 3, 2013 - v2
    Checksum:i3A7EE5FED65F9B8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06056307 Genomic DNA. No translation available.
    AABR06056308 Genomic DNA. No translation available.
    AABR06056309 Genomic DNA. No translation available.
    AABR06056310 Genomic DNA. No translation available.
    AABR06056311 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000018794; ENSRNOP00000018794; ENSRNOG00000014025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06056307 Genomic DNA. No translation available.
    AABR06056308 Genomic DNA. No translation available.
    AABR06056309 Genomic DNA. No translation available.
    AABR06056310 Genomic DNA. No translation available.
    AABR06056311 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1LM43.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018794 ; ENSRNOP00000018794 ; ENSRNOG00000014025 .

    Organism-specific databases

    RGDi 620395. Rasgrf1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110221.
    OMAi SMYSAMS.
    OrthoDBi EOG7H1JKP.

    Miscellaneous databases

    NextBioi 35575394.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    InterProi IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00169. PH. 2 hits.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00015. IQ. 1 hit.
    SM00233. PH. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 2 hits.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF48366. SSF48366. 2 hits.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50096. IQ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LM43_RAT
    AccessioniPrimary (citable) accession number: F1LM43
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 30 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3