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F1LM16

- F1LM16_RAT

UniProt

F1LM16 - F1LM16_RAT

Protein
Submitted name:

Plasminogen activator inhibitor 1

Gene

Serpine1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cellular response to lipopolysaccharide Source: Ensembl
    3. chronological cell aging Source: Ensembl
    4. defense response to Gram-negative bacterium Source: Ensembl
    5. negative regulation of cell adhesion mediated by integrin Source: Ensembl
    6. negative regulation of endothelial cell apoptotic process Source: Ensembl
    7. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    8. negative regulation of fibrinolysis Source: Ensembl
    9. negative regulation of plasminogen activation Source: Ensembl
    10. negative regulation of smooth muscle cell-matrix adhesion Source: Ensembl
    11. negative regulation of smooth muscle cell migration Source: Ensembl
    12. negative regulation of vascular wound healing Source: Ensembl
    13. positive regulation of angiogenesis Source: Ensembl
    14. positive regulation of interleukin-8 production Source: Ensembl
    15. positive regulation of leukotriene production involved in inflammatory response Source: Ensembl
    16. positive regulation of monocyte chemotaxis Source: Ensembl
    17. positive regulation of receptor-mediated endocytosis Source: Ensembl
    18. regulation of cell proliferation Source: Ensembl
    19. regulation of receptor activity Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_198757. ECM proteoglycans.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Plasminogen activator inhibitor 1Imported
    Gene namesi
    Name:Serpine1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi3249. Serpine1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115460.
    OMAiNLACTIN.
    OrthoDBiEOG7327PB.
    TreeFamiTF352620.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LM16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQMSSALTCL TLGLVLVFGK GFASPLPESH TAQQATNFGV KVFQHVVQAS    50
    KDRNVVFSPY GVSSVLAMLQ LTTAGKTRQQ IQDAMGFNIS ERGTAPALRK 100
    LSKELMGSWN KNEISTADAI FVQRDLELVQ GFMPHFFKLF RTTVKQVDFS 150
    EMERARFIIN DWVERHTKGM ISDLLAKGAV NELTRLVLVN ALYFNGQWKT 200
    PFLEASTHQR LFHKSDGSTI SVPMMAQNNK FNYTEFTTPD GHEYDILELP 250
    YHGETLSMFI AAPFEKDVPL SAITNILDAE LIRQWKSNMT RLPRLLILPK 300
    FSLETEVDLR GPLEKLGMTD IFSSTQADFT SLSDQEQLSV AQALQKVKIE 350
    VNESGTVASS STAILVSARM APTEMVLDRS FLFVVRHNPT ETILFMGQLM 400
    EP 402
    Length:402
    Mass (Da):45,042
    Last modified:May 3, 2011 - v1
    Checksum:i2B6397F7F475E403
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06071123 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000001916; ENSRNOP00000001916; ENSRNOG00000001414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06071123 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000001916 ; ENSRNOP00000001916 ; ENSRNOG00000001414 .

    Organism-specific databases

    RGDi 3249. Serpine1.

    Phylogenomic databases

    GeneTreei ENSGT00740000115460.
    OMAi NLACTIN.
    OrthoDBi EOG7327PB.
    TreeFami TF352620.

    Enzyme and pathway databases

    Reactomei REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_198757. ECM proteoglycans.

    Miscellaneous databases

    NextBioi 35575367.
    PROi F1LM16.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LM16_RAT
    AccessioniPrimary (citable) accession number: F1LM16
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3