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F1LLX2

- F1LLX2_RAT

UniProt

F1LLX2 - F1LLX2_RAT

Protein
Submitted name:

D(4) dopamine receptor

Gene

Drd4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
    3. drug binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
    3. adult locomotory behavior Source: Ensembl
    4. arachidonic acid secretion Source: Ensembl
    5. behavioral response to cocaine Source: Ensembl
    6. fear response Source: Ensembl
    7. negative regulation of adenylate cyclase activity Source: Ensembl
    8. negative regulation of protein secretion Source: Ensembl
    9. negative regulation of voltage-gated calcium channel activity Source: Ensembl
    10. positive regulation of sodium:proton antiporter activity Source: Ensembl
    11. regulation of dopamine metabolic process Source: Ensembl
    12. regulation of inhibitory postsynaptic membrane potential Source: Ensembl
    13. response to amphetamine Source: Ensembl
    14. response to histamine Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    D(4) dopamine receptorImported
    Gene namesi
    Name:Drd4Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2522. Drd4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliF1LLX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117240.
    KOiK04147.
    OMAiDPAVCRL.
    OrthoDBiEOG769ZMG.
    TreeFamiTF334382.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002185. Dopamine_D4_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24249:SF37. PTHR24249:SF37. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00569. DOPAMINED4R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1LLX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNSSATGDG GLLAGRGPES LGTGTGLGGA GAGAAALVGG VLLIGMVLAG    50
    NSLVCVSVAS ERILQTPTNY FIVSLAAADL LLAVLVLPLF VYSEVQGGVW 100
    LLSPRLCDTL MAMDVMLCTA SIFNLCAISV DRFVAVTVPL RYNQQGQCQL 150
    LLIAATWLLS AAVAAPVVCG LNDVPGRDPT VCCLEDRDYV VYSSICSFFL 200
    PCPLMLLLYW ATFRGLRRWE AARHTKLHSR APRRPSGPGP PVSDPTQGPL 250
    FSDCPPPSPS LRTSPTVSSR PESDLSQSPC SPGCLLPDAA LAQPPAPSSR 300
    RKRGAKITGR ERKAMRVLPV VVGAFLMCWT PFFVVHITRA LCPACFVSPR 350
    LVSAVTWLGY VNSALNPIIY TIFNAEFRSV FRKTLRLRC 389
    Length:389
    Mass (Da):41,423
    Last modified:May 3, 2011 - v1
    Checksum:i02EC03251E8FCEB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06009341 Genomic DNA. No translation available.
    RefSeqiXP_006230583.1. XM_006230521.1.
    UniGeneiRn.10159.

    Genome annotation databases

    EnsembliENSRNOT00000024137; ENSRNOP00000024137; ENSRNOG00000017927.
    GeneIDi25432.
    KEGGirno:25432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06009341 Genomic DNA. No translation available.
    RefSeqi XP_006230583.1. XM_006230521.1.
    UniGenei Rn.10159.

    3D structure databases

    ProteinModelPortali F1LLX2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024137 ; ENSRNOP00000024137 ; ENSRNOG00000017927 .
    GeneIDi 25432.
    KEGGi rno:25432.

    Organism-specific databases

    CTDi 1815.
    RGDi 2522. Drd4.

    Phylogenomic databases

    GeneTreei ENSGT00750000117240.
    KOi K04147.
    OMAi DPAVCRL.
    OrthoDBi EOG769ZMG.
    TreeFami TF334382.

    Miscellaneous databases

    NextBioi 35575325.
    PROi F1LLX2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002185. Dopamine_D4_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24249:SF37. PTHR24249:SF37. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00569. DOPAMINED4R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1LLX2_RAT
    AccessioniPrimary (citable) accession number: F1LLX2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3