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F1LLX2

- F1LLX2_RAT

UniProt

F1LLX2 - F1LLX2_RAT

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Protein
Submitted name:

D(4) dopamine receptor

Gene

Drd4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
  3. drug binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
  3. adult locomotory behavior Source: Ensembl
  4. arachidonic acid secretion Source: Ensembl
  5. behavioral response to cocaine Source: Ensembl
  6. fear response Source: Ensembl
  7. negative regulation of adenylate cyclase activity Source: Ensembl
  8. negative regulation of protein secretion Source: Ensembl
  9. negative regulation of voltage-gated calcium channel activity Source: Ensembl
  10. positive regulation of sodium:proton antiporter activity Source: Ensembl
  11. regulation of circadian rhythm Source: Ensembl
  12. regulation of dopamine metabolic process Source: Ensembl
  13. regulation of inhibitory postsynaptic membrane potential Source: Ensembl
  14. response to amphetamine Source: Ensembl
  15. response to histamine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
D(4) dopamine receptorImported
Gene namesi
Name:Drd4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2522. Drd4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiF1LLX2. baseline.

Structurei

3D structure databases

ProteinModelPortaliF1LLX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118795.
KOiK04147.
OMAiDPAVCRL.
OrthoDBiEOG769ZMG.
TreeFamiTF334382.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LLX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNSSATGDG GLLAGRGPES LGTGTGLGGA GAGAAALVGG VLLIGMVLAG
60 70 80 90 100
NSLVCVSVAS ERILQTPTNY FIVSLAAADL LLAVLVLPLF VYSEVQGGVW
110 120 130 140 150
LLSPRLCDTL MAMDVMLCTA SIFNLCAISV DRFVAVTVPL RYNQQGQCQL
160 170 180 190 200
LLIAATWLLS AAVAAPVVCG LNDVPGRDPT VCCLEDRDYV VYSSICSFFL
210 220 230 240 250
PCPLMLLLYW ATFRGLRRWE AARHTKLHSR APRRPSGPGP PVSDPTQGPL
260 270 280 290 300
FSDCPPPSPS LRTSPTVSSR PESDLSQSPC SPGCLLPDAA LAQPPAPSSR
310 320 330 340 350
RKRGAKITGR ERKAMRVLPV VVGAFLMCWT PFFVVHITRA LCPACFVSPR
360 370 380
LVSAVTWLGY VNSALNPIIY TIFNAEFRSV FRKTLRLRC
Length:389
Mass (Da):41,423
Last modified:May 3, 2011 - v1
Checksum:i02EC03251E8FCEB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06009341 Genomic DNA. No translation available.
RefSeqiXP_006230583.1. XM_006230521.1.
UniGeneiRn.10159.

Genome annotation databases

EnsembliENSRNOT00000024137; ENSRNOP00000024137; ENSRNOG00000017927.
GeneIDi25432.
KEGGirno:25432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06009341 Genomic DNA. No translation available.
RefSeqi XP_006230583.1. XM_006230521.1.
UniGenei Rn.10159.

3D structure databases

ProteinModelPortali F1LLX2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024137 ; ENSRNOP00000024137 ; ENSRNOG00000017927 .
GeneIDi 25432.
KEGGi rno:25432.

Organism-specific databases

CTDi 1815.
RGDi 2522. Drd4.

Phylogenomic databases

GeneTreei ENSGT00760000118795.
KOi K04147.
OMAi DPAVCRL.
OrthoDBi EOG769ZMG.
TreeFami TF334382.

Miscellaneous databases

NextBioi 35575325.
PROi F1LLX2.

Gene expression databases

ExpressionAtlasi F1LLX2. baseline.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24249:SF37. PTHR24249:SF37. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LLX2_RAT
AccessioniPrimary (citable) accession number: F1LLX2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3