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F1LLX2

- F1LLX2_RAT

UniProt

F1LLX2 - F1LLX2_RAT

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Protein
Submitted name: D(4) dopamine receptor
Gene
Drd4
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
  3. drug binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
  3. adult locomotory behavior Source: Ensembl
  4. arachidonic acid secretion Source: Ensembl
  5. behavioral response to cocaine Source: Ensembl
  6. fear response Source: Ensembl
  7. negative regulation of adenylate cyclase activity Source: Ensembl
  8. negative regulation of protein secretion Source: Ensembl
  9. negative regulation of voltage-gated calcium channel activity Source: Ensembl
  10. positive regulation of sodium:proton antiporter activity Source: Ensembl
  11. regulation of dopamine metabolic process Source: Ensembl
  12. regulation of inhibitory postsynaptic membrane potential Source: Ensembl
  13. response to amphetamine Source: Ensembl
  14. response to histamine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
D(4) dopamine receptorImported
Gene namesi
Name:Drd4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2522. Drd4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliF1LLX2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117240.
KOiK04147.
OMAiDPAVCRL.
OrthoDBiEOG769ZMG.
TreeFamiTF334382.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LLX2-1 [UniParc]FASTAAdd to Basket

« Hide

MGNSSATGDG GLLAGRGPES LGTGTGLGGA GAGAAALVGG VLLIGMVLAG    50
NSLVCVSVAS ERILQTPTNY FIVSLAAADL LLAVLVLPLF VYSEVQGGVW 100
LLSPRLCDTL MAMDVMLCTA SIFNLCAISV DRFVAVTVPL RYNQQGQCQL 150
LLIAATWLLS AAVAAPVVCG LNDVPGRDPT VCCLEDRDYV VYSSICSFFL 200
PCPLMLLLYW ATFRGLRRWE AARHTKLHSR APRRPSGPGP PVSDPTQGPL 250
FSDCPPPSPS LRTSPTVSSR PESDLSQSPC SPGCLLPDAA LAQPPAPSSR 300
RKRGAKITGR ERKAMRVLPV VVGAFLMCWT PFFVVHITRA LCPACFVSPR 350
LVSAVTWLGY VNSALNPIIY TIFNAEFRSV FRKTLRLRC 389
Length:389
Mass (Da):41,423
Last modified:May 3, 2011 - v1
Checksum:i02EC03251E8FCEB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06009341 Genomic DNA. No translation available.
RefSeqiXP_006230583.1. XM_006230521.1.
UniGeneiRn.10159.

Genome annotation databases

EnsembliENSRNOT00000024137; ENSRNOP00000024137; ENSRNOG00000017927.
GeneIDi25432.
KEGGirno:25432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06009341 Genomic DNA. No translation available.
RefSeqi XP_006230583.1. XM_006230521.1.
UniGenei Rn.10159.

3D structure databases

ProteinModelPortali F1LLX2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024137 ; ENSRNOP00000024137 ; ENSRNOG00000017927 .
GeneIDi 25432.
KEGGi rno:25432.

Organism-specific databases

CTDi 1815.
RGDi 2522. Drd4.

Phylogenomic databases

GeneTreei ENSGT00750000117240.
KOi K04147.
OMAi DPAVCRL.
OrthoDBi EOG769ZMG.
TreeFami TF334382.

Miscellaneous databases

NextBioi 35575325.
PROi F1LLX2.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24249:SF37. PTHR24249:SF37. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1LLX2_RAT
AccessioniPrimary (citable) accession number: F1LLX2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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