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Protein
Submitted name:

Aquaporin 4 transcript variant a

Gene

AQP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Aquaporin 4 transcript variant aImported
Submitted name:
Aquaporin 4, isoform CRA_aImported
Gene namesi
Name:AQP4Imported
ORF Names:hCG_37174Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 51HelicalSequence analysisAdd BLAST19
Transmembranei71 – 94HelicalSequence analysisAdd BLAST24
Transmembranei115 – 136HelicalSequence analysisAdd BLAST22
Transmembranei156 – 177HelicalSequence analysisAdd BLAST22
Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
Transmembranei231 – 253HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSG00000171885.
ExpressionAtlasiF1DSG4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000372654.

Structurei

3D structure databases

ProteinModelPortaliF1DSG4.
SMRiF1DSG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
KOiK09866.
OMAiCRRESIM.
OrthoDBiEOG091G166T.
PhylomeDBiF1DSG4.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

F1DSG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL
60 70 80 90 100
LSLGSTINWG GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV
110 120 130 140 150
TVAMVCTRKI SIAKSVFYIA AQCLGAIIGA GILYLVTPPS VVGGLGVTMV
160 170 180 190 200
HGNLTAGHGL LVELIITFQL VFTIFASCDS KRTDVTGSIA LAIGFSVAIG
210 220 230 240 250
HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG AVLAGGLYEY
260 270 280 290 300
VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH
310 320
VIDVDRGEEK KGKDQSGEVL SSV
Length:323
Mass (Da):34,830
Last modified:May 3, 2011 - v1
Checksum:i1A1600CF0DC11052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ901095 mRNA. Translation: ADZ13511.1.
CH471088 Genomic DNA. Translation: EAX01228.1.
CH471088 Genomic DNA. Translation: EAX01229.1.
RefSeqiNP_001304313.1. NM_001317384.1.
NP_001304316.1. NM_001317387.1.
NP_001641.1. NM_001650.5.
NP_004019.1. NM_004028.4.
UniGeneiHs.315369.

Genome annotation databases

GeneIDi361.
KEGGihsa:361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ901095 mRNA. Translation: ADZ13511.1.
CH471088 Genomic DNA. Translation: EAX01228.1.
CH471088 Genomic DNA. Translation: EAX01229.1.
RefSeqiNP_001304313.1. NM_001317384.1.
NP_001304316.1. NM_001317387.1.
NP_001641.1. NM_001650.5.
NP_004019.1. NM_004028.4.
UniGeneiHs.315369.

3D structure databases

ProteinModelPortaliF1DSG4.
SMRiF1DSG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000372654.

Protocols and materials databases

DNASUi361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361.
KEGGihsa:361.

Organism-specific databases

CTDi361.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
KOiK09866.
OMAiCRRESIM.
OrthoDBiEOG091G166T.
PhylomeDBiF1DSG4.

Miscellaneous databases

ChiTaRSiAQP4. human.
GenomeRNAii361.

Gene expression databases

BgeeiENSG00000171885.
ExpressionAtlasiF1DSG4. baseline and differential.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF1DSG4_HUMAN
AccessioniPrimary (citable) accession number: F1DSG4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 12, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.