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Protein
Submitted name:

Germ cell nuclear factor

Gene

NR6A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi53 – 128Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Germ cell nuclear factorImported
Submitted name:
Nuclear receptor subfamily 6, group A, member 1, isoform CRA_aImported
Gene namesi
Name:NR6A1Imported
ORF Names:hCG_29220Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000148200.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000148200
ExpressionAtlasiF1DAM1 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 128Nuclear receptorInterPro annotationAdd BLAST76
Domaini245 – 476NR LBDInterPro annotationAdd BLAST232

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1DAM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTNDR
60 70 80 90 100
AEQRTCLICG DRATGLHYGI ISCEGCKGFF KRSICNKRVY RCSRDKNCVM
110 120 130 140 150
SRKQRNRCQY CRLLKCLQMG MNRKAIREDG MPGGRNKSIG PVQISEEEIE
160 170 180 190 200
RIMSGQEFEE EANHWSNHGD SDHSSPGNRA SESNQPSPGS TLSSSRSVEL
210 220 230 240 250
NGFMAFREQY MGMSVPPHYQ YIPHLFSYSG HSPLLPQQAR SLDPQSYSLI
260 270 280 290 300
HQLLSAEDLE PLGTPMLIED GYAVTQAELF ALLCRLADEL LFRQIAWIKK
310 320 330 340 350
LPFFCELSIK DYTCLLSSTW QELILLSSLT VYSKQIFGEL ADVTAKYSPS
360 370 380 390 400
DEELHRFSDE GMEVIERLIY LYHKFHQLKV SNEEYACMKA INFLNQDIRG
410 420 430 440 450
LTSASQLEQL NKRYWYICQD FTEYKYTHQP NRFPDLMMCL PEIRYIAGKM
460 470
VNVPLEQLPL LFKVVLHSCK TSVGKE
Length:476
Mass (Da):53,996
Last modified:May 3, 2011 - v1
Checksum:i6C7881E654CC9046
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ709185 mRNA Translation: ADZ17392.1
CH471090 Genomic DNA Translation: EAW87593.1
RefSeqiNP_001265475.1, NM_001278546.1
UniGeneiHs.20131
Hs.586460

Genome annotation databases

GeneIDi2649

Similar proteinsi

Entry informationi

Entry nameiF1DAM1_HUMAN
AccessioniPrimary (citable) accession number: F1DAM1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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