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F1DAL3

- F1DAL3_HUMAN

UniProt

F1DAL3 - F1DAL3_HUMAN

Protein
Submitted name:

Pregnane X nuclear receptor

Gene

NR1I2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. steroid hormone receptor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of gene expression Source: Ensembl
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pregnane X nuclear receptorImported
    Gene namesi
    Name:NR1I2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiF1DAL3.
    BgeeiF1DAL3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1DAL3-1 [UniParc]FASTAAdd to Basket

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    MTVTRTHHFK EGSLRAPAIP LHSAAAELAS NHPRGPEANL EVRPKESWNH    50
    ADFVHCEDTE SVPGKPSVNA DEEVGGPQIC RVCGDKATGY HFNVMTCEGC 100
    KGFFRRAMKR NARLRCPFRK GACEITRKTR RQCQACRLRK CLESGMKKEM 150
    IMSDEAVEER RALIKRKKSE RTGTQPLGVT EEQRMMIREL MDAQMKTFDT 200
    TFSHFKNFRL PGVLSSGCEL PESLQAPSRE EAAKWSQVRK DLCSLKVSLQ 250
    LRGEDGSVWN YKPPADSGGK EIFSLLPHMA DMSTYMFKGI ISFAKVISYF 300
    RDLPIEDQIS LLKGAAFELC QLRFNTVFNA ETGTWECGRL SYCLEDTAGG 350
    FQQLLLEPML KFHYMLKKLQ LHEEEYVLMQ AISLFSPDRP GVLQHRVVDQ 400
    LQEQFAITLK SYIECNRPQP AHRFLFLKIM AMLTELRSIN AQHTQRLLRI 450
    QDIHPFATPL MQELFGITGS 470
    Length:470
    Mass (Da):53,601
    Last modified:May 3, 2011 - v1
    Checksum:i89188532394A004F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ709177 mRNA. Translation: ADZ17384.1.
    UniGeneiHs.7303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ709177 mRNA. Translation: ADZ17384.1 .
    UniGenei Hs.7303.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35505315.

    Gene expression databases

    ArrayExpressi F1DAL3.
    Bgeei F1DAL3.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA coding for putatively new variants of multiple human nuclear receptors."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiF1DAL3_HUMAN
    AccessioniPrimary (citable) accession number: F1DAL3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.