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Protein
Submitted name:

Thyroid hormone nuclear receptor alpha

Gene

NR1F1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 90Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Thyroid hormone nuclear receptor alphaImported
Gene namesi
Name:NR1F1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF1DAL0.
PeptideAtlasiF1DAL0.

Expressioni

Gene expression databases

BgeeiENSG00000069667.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 90Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4216. Eukaryota.
ENOG410XUGR. LUCA.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003079. ROR_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F1DAL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYFVIAAMK AQIEIIPCKI CGDKSSGIHY GVITCEGCKG FFRRSQQSNA
60 70 80 90 100
TYSCPRQKNC LIDRTSRNRC QHCRLQKCLA VGMSRDAVKF GRMSKKQRDS
110 120 130 140 150
LYAEVQKHRM QQQQRDHQQQ PGEAEPLTPT YNISANGLTE LHDDLSNYID
160 170 180 190 200
GHTPEGSKAD SAVSSFYLDI QPSPDQSGLD INGIKPEPIC DYTPASGFFP
210 220 230 240 250
YCSFTNGETS PTVSMAELEH LAQNISKSHL ETCQYLREEL QQITWQTFLQ
260 270 280 290 300
EEIENYQNKR EVMWQLCAIK ITEAIQYVVE FAKRIDGFME LCQNDQIVLL
310 320 330 340 350
KAGSLEVVFI RMCRAFDSQN NTVYFDGKYA SPDVFKSLGC EDFISFVFEF
360 370 380 390 400
GKSLCSMHLT EDEIALFSAF VLMSADRSWL QEKVKIEKLQ QKIQLALQHV
410 420 430 440 450
LQKNHREDGI LTKLICKVST LRALCGRHTE KLMAFKAIYP DIVRLHFPPL
460
YKELFTSEFE PAMQIDG
Length:467
Mass (Da):53,412
Last modified:May 3, 2011 - v1
Checksum:i47FCD7891A149D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ709174 mRNA. Translation: ADZ17381.1.
UniGeneiHs.560343.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF1DAL0_HUMAN
AccessioniPrimary (citable) accession number: F1DAL0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 5, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.