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F1D8T1

- F1D8T1_HUMAN

UniProt

F1D8T1 - F1D8T1_HUMAN

Protein
Submitted name:

Hepatocyte nuclear factor 4 4 alpha variant 2

Gene

NR2A1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. sequence-specific DNA binding Source: Ensembl
    4. steroid hormone receptor activity Source: InterPro
    5. transcription regulatory region DNA binding Source: Ensembl
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glucose homeostasis Source: Ensembl
    2. lipid metabolic process Source: Ensembl
    3. phospholipid homeostasis Source: Ensembl
    4. positive regulation of cholesterol homeostasis Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    6. regulation of gastrulation Source: Ensembl
    7. regulation of insulin secretion Source: Ensembl
    8. response to glucose Source: Ensembl
    9. sex differentiation Source: Ensembl
    10. signal transduction involved in regulation of gene expression Source: Ensembl
    11. SMAD protein signal transduction Source: Ensembl
    12. triglyceride homeostasis Source: Ensembl

    Keywords - Molecular functioni

    ReceptorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hepatocyte nuclear factor 4 4 alpha variant 2Imported
    Gene namesi
    Name:NR2A1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiF1D8T1.

    Expressioni

    Gene expression databases

    ArrayExpressiF1D8T1.
    BgeeiF1D8T1.

    Structurei

    3D structure databases

    ProteinModelPortaliF1D8T1.
    SMRiF1D8T1. Positions 58-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    KOiK07292.
    OMAiANTMPSH.
    PhylomeDBiF1D8T1.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1D8T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA    50
    PNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR 100
    QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP 150
    SINALLQAEV LSRQITSPVS GINGDIRAKK IASIADVCES MKEQLLVLVE 200
    WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI 250
    VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYAYLK AIIFFDPDAK 300
    GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ 350
    MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT 400
    NVIVANTMPT HLSNGQMCEW PRPRGQAATP ETPQPSPPGG SGSEPYKLLP 450
    GAVATIVKPL SAIPQPTITK QEVI 474
    Length:474
    Mass (Da):52,785
    Last modified:May 3, 2011 - v1
    Checksum:i5F1309B89D95DCAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ692869 mRNA. Translation: ADZ17380.1.
    RefSeqiNP_000448.3. NM_000457.4.
    NP_001245284.1. NM_001258355.1.
    UniGeneiHs.116462.

    Genome annotation databases

    GeneIDi3172.
    KEGGihsa:3172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ692869 mRNA. Translation: ADZ17380.1 .
    RefSeqi NP_000448.3. NM_000457.4.
    NP_001245284.1. NM_001258355.1.
    UniGenei Hs.116462.

    3D structure databases

    ProteinModelPortali F1D8T1.
    SMRi F1D8T1. Positions 58-377.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1D8T1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3172.
    KEGGi hsa:3172.

    Organism-specific databases

    CTDi 3172.

    Phylogenomic databases

    KOi K07292.
    OMAi ANTMPSH.
    PhylomeDBi F1D8T1.

    Miscellaneous databases

    GenomeRNAii 3172.
    NextBioi 12578.

    Gene expression databases

    ArrayExpressi F1D8T1.
    Bgeei F1D8T1.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA coding for multiple human nuclear receptor clones."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiF1D8T1_HUMAN
    AccessioniPrimary (citable) accession number: F1D8T1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.