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Protein
Submitted name:

Hepatocyte nuclear factor 4 4 alpha variant 4

Gene

NR2A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi35 – 110Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte nuclear factor 4 4 alpha variant 4Imported
Submitted name:
Hepatocyte nuclear factor 4, alpha, isoform CRA_aImported
Gene namesi
Name:NR2A1Imported
Synonyms:HNF4AImported
ORF Names:hCG_38107Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000101076.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000101076
ExpressionAtlasiF1D8T0 baseline and differential

Structurei

3D structure databases

SMRiF1D8T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 110Nuclear receptorInterPro annotationAdd BLAST76
Domaini125 – 355NR LBDInterPro annotationAdd BLAST231

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4215 Eukaryota
ENOG410XQT8 LUCA

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1D8T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVNAPLGA PVESSYDTSP SEGTNLNAPN SLGVSALCAI CGDRATGKHY
60 70 80 90 100
GASSCDGCKG FFRRSVRKNH MYSCRFSRQC VVDKDKRNQC RYCRLKKCFR
110 120 130 140 150
AGMKKEAVQN ERDRISTRRS SYEDSSLPSI NALLQAEVLS RQITSPVSGI
160 170 180 190 200
NGDIRAKKIA SIADVCESMK EQLLVLVEWA KYIPAFCELP LDDQVALLRA
210 220 230 240 250
HAGEHLLLGA TKRSMVFKDV LLLGNDYIVP RHCPELAEMS RVSIRILDEL
260 270 280 290 300
VLPFQELQID DNEYAYLKAI IFFDPDAKGL SDPGKIKRLR SQVQVSLEDY
310 320 330 340 350
INDRQYDSRG RFGELLLLLP TLQSITWQMI EQIQFIKLFG MAKIDNLLQE
360 370 380 390 400
MLLGGSPSDA PHAHHPLHPH LMQEHMGTNV IVANTMPTHL SNGQMCEWPR
410 420 430 440 450
PRGQAATPET PQPSPPGGSG SEPYKLLPGA VATIVKPLSA IPQPTITKQE

VI
Length:452
Mass (Da):50,150
Last modified:May 3, 2011 - v1
Checksum:i96854D18F389B0F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692868 mRNA Translation: ADZ17379.1
CH471077 Genomic DNA Translation: EAW75921.1
RefSeqiNP_787110.2, NM_175914.4
UniGeneiHs.116462

Genome annotation databases

GeneIDi3172

Similar proteinsi

Entry informationi

Entry nameiF1D8T0_HUMAN
AccessioniPrimary (citable) accession number: F1D8T0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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