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F1D8S2

- F1D8S2_HUMAN

UniProt

F1D8S2 - F1D8S2_HUMAN

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Protein
Submitted name: Hepatocyte nuclear factor 4 4 alpha variant 1
Gene
NR2A1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte nuclear factor 4 4 alpha variant 1Imported
Gene namesi
Name:NR2A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiF1D8S2.

Expressioni

Gene expression databases

ArrayExpressiF1D8S2.
BgeeiF1D8S2.

Structurei

3D structure databases

ProteinModelPortaliF1D8S2.
SMRiF1D8S2. Positions 58-135, 148-377.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Phylogenomic databases

KOiK07292.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1D8S2-1 [UniParc]FASTAAdd to Basket

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MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA    50
PNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR 100
QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP 150
SINALLQAEV LSRQITSPVS GINGDIRAKK IASIADVCES MKEQLLVLVE 200
WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI 250
VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYAYLK AIIFFDPDAK 300
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ 350
MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT 400
NVIVANTMPT HLSNGQMSTP ETPQPSPPGG SGSEPYKLLP GAVATIVKPL 450
SAIPQPTITK QEVI 464
Length:464
Mass (Da):51,619
Last modified:May 3, 2011 - v1
Checksum:iFF0A4FB233ADCC56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ692860 mRNA. Translation: ADZ17371.1.
RefSeqiNP_849180.1. NM_178849.2.
UniGeneiHs.116462.

Genome annotation databases

GeneIDi3172.
KEGGihsa:3172.
UCSCiuc002xlz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ692860 mRNA. Translation: ADZ17371.1 .
RefSeqi NP_849180.1. NM_178849.2.
UniGenei Hs.116462.

3D structure databases

ProteinModelPortali F1D8S2.
SMRi F1D8S2. Positions 58-135, 148-377.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1D8S2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3172.
KEGGi hsa:3172.
UCSCi uc002xlz.4. human.

Organism-specific databases

CTDi 3172.

Phylogenomic databases

KOi K07292.

Miscellaneous databases

GenomeRNAii 3172.
NextBioi 12578.

Gene expression databases

ArrayExpressi F1D8S2.
Bgeei F1D8S2.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of cDNA coding for multiple human nuclear receptor clones."
    Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.

Entry informationi

Entry nameiF1D8S2_HUMAN
AccessioniPrimary (citable) accession number: F1D8S2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 16, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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