Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F1D8Q5 (F1D8Q5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:NR2B1 EMBL ADZ17354.1
OrganismHomo sapiens (Human) EMBL ADZ17354.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
   Biological processTranscription
Transcription regulation RuleBase RU004334 SAAS SAAS008946
   Cellular componentNucleus RuleBase RU004334 SAAS SAAS008946
   DomainZinc-finger RuleBase RU004334 SAAS SAAS008946
   LigandDNA-binding RuleBase RU004334 SAAS SAAS008946
Metal-binding
Zinc
   Molecular functionReceptor RuleBase RU004334 EMBL ADZ17354.1
Gene Ontology (GO)
   Biological_processcardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

embryo implantation

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

maternal placenta development

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of branching involved in prostate gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_function9-cis retinoic acid receptor activity

Inferred from electronic annotation. Source: Ensembl

chromatin DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
F1D8Q5 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 7F952B580AD84C42

FASTA46250,811
        10         20         30         40         50         60 
MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP ISTLSSPING 

        70         80         90        100        110        120 
MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP VSSSEDIKPP LGLNGVLKVP 

       130        140        150        160        170        180 
AHPSGNMASF TKHICAICGD RSSGKHYGVY SCEGCKGFFK RTVRKDLTYT CRDNKDCLID 

       190        200        210        220        230        240 
KRQRNRCQYC RYQKCLAMGM KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL 

       250        260        270        280        290        300 
AVEPKTETYV EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL 

       310        320        330        340        350        360 
LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL TELVSKMRDM 

       370        380        390        400        410        420 
QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL EAYCKHKYPE QPGRFAKLLL 

       430        440        450        460 
RLPALRSIGL KCLEHLFFFK LIGDTPIDTF LMEMLEAPHQ MT 

« Hide

References

[1]"Isolation of cDNA coding for multiple human nuclear receptor clones."
Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Kidney EMBL ADZ17354.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HQ692843 mRNA. Translation: ADZ17354.1.
RefSeqNP_002948.1. NM_002957.4.
UniGeneHs.590886.

3D structure databases

ProteinModelPortalF1D8Q5.
SMRF1D8Q5. Positions 132-459.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEF1D8Q5.

Protocols and materials databases

DNASU6256.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6256.
KEGGhsa:6256.

Organism-specific databases

CTD6256.

Phylogenomic databases

KOK08524.
OMAKHFLPLD.
PhylomeDBF1D8Q5.

Gene expression databases

ArrayExpressF1D8Q5.
BgeeF1D8Q5.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6256.
NextBio24295.

Entry information

Entry nameF1D8Q5_HUMAN
AccessionPrimary (citable) accession number: F1D8Q5
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 16, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.