F1D8Q5 (F1D8Q5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Retinoid X nuclear receptor alpha EMBL ADZ17354.1

Gene names

Name:

NR2B1 EMBL ADZ17354.1

Organism

Homo sapiens (Human) EMBL ADZ17354.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS000536
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS000536
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS000536
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL ADZ17354.1
Gene Ontology (GO)
Biological_process	cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara maternal placenta development Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of branching involved in prostate gland morphogenesis Inferred from electronic annotation. Source: Compara secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Inferred from electronic annotation. Source: Compara ventricular cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara ventricular cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	9-cis retinoic acid receptor activity Inferred from electronic annotation. Source: Compara chromatin DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: Compara steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F1D8Q5 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 7F952B580AD84C42	FASTA	462	50,811
	10 20 30 40 50 60 MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP ISTLSSPING 70 80 90 100 110 120 MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP VSSSEDIKPP LGLNGVLKVP 130 140 150 160 170 180 AHPSGNMASF TKHICAICGD RSSGKHYGVY SCEGCKGFFK RTVRKDLTYT CRDNKDCLID 190 200 210 220 230 240 KRQRNRCQYC RYQKCLAMGM KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL 250 260 270 280 290 300 AVEPKTETYV EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL 310 320 330 340 350 360 LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL TELVSKMRDM 370 380 390 400 410 420 QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL EAYCKHKYPE QPGRFAKLLL 430 440 450 460 RLPALRSIGL KCLEHLFFFK LIGDTPIDTF LMEMLEAPHQ MT

References

[1]	"Isolation of cDNA coding for multiple human nuclear receptor clones." Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Kidney EMBL ADZ17354.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HQ692843 mRNA. Translation: ADZ17354.1.
IPI	IPI00418394.
RefSeq	NP_002948.1. NM_002957.4.
UniGene	Hs.590886.
3D structure databases
ProteinModelPortal	F1D8Q5.
ModBase	Search...
Proteomic databases
PRIDE	F1D8Q5.
Protocols and materials databases
DNASU	6256.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6256.
KEGG	hsa:6256.
Organism-specific databases
CTD	6256.
Phylogenomic databases
KO	K08524.
OMA	KHFLPLD.
Gene expression databases
ArrayExpress	F1D8Q5.
Bgee	F1D8Q5.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR021780. Nuc_recep-AF1. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR000003. Retinoid-X_rcpt/HNF4. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF11825. Nuc_recep-AF1. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00545. RETINOIDXR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6256.
NextBio	24295.

Entry information

Entry name

F1D8Q5_HUMAN

Accession

Primary (citable) accession number: F1D8Q5

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.