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Protein
Submitted name:

Nuclear receptor subfamily 1, group I, member 2, isoform CRA_b

Gene

NR1i2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi77 – 153Nuclear receptorPROSITE-ProRule annotationAdd BLAST77

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor subfamily 1, group I, member 2, isoform CRA_bImported
Submitted name:
Pregnane X nuclear receptor variant 2Imported
Gene namesi
Name:NR1i2Imported
Synonyms:NR1I2Imported
ORF Names:hCG_21777Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000144852.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000144852
ExpressionAtlasiF1D8P9 baseline and differential

Structurei

3D structure databases

SMRiF1D8P9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 153Nuclear receptorInterPro annotationAdd BLAST77
Domaini185 – 472NR LBDInterPro annotationAdd BLAST288

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
OMAiYIECNRP
OrthoDBiEOG091G05X3

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1D8P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTRTHHFK EGSLRAPAIP LHSAAAELAS NHPRGPEANL EVRPKESWNH
60 70 80 90 100
ADFVHCEDTE SVPGKPSVNA DEEVGGPQIC RVCGDKATGY HFNVMTCEGC
110 120 130 140 150
KGFFRRAMKR NARLRCPFRK GACEITRKTR RQCQACRLRK CLESGMKKEM
160 170 180 190 200
IMSDEAVEER RALIKRKKSE RTGTQPLGVQ GLTEEQRMMI RELMDAQMKT
210 220 230 240 250
FDTTFSHFKN FRLPGVLSSG CELPESLQAP SREEAAKWSQ VRKDLCSLKV
260 270 280 290 300
SLQLRGEDGS VWNYKPPADS GGKEIFSLLP HMADMSTYMF KGIISFAKVI
310 320 330 340 350
SYFRDLPIED QISLLKGAAF ELCQLRFNTV FNAETGTWEC GRLSYCLEDT
360 370 380 390 400
AGGFQQLLLE PMLKFHYMLK KLQLHEEEYV LMQAISLFSP DRPGVLQHRV
410 420 430 440 450
VDQLQEQFAI TLKSYIECNR PQPAHRFLFL KIMAMLTELR SINAQHTQRL
460 470
LRIQDIHPFA TPLMQELFGI TGS
Length:473
Mass (Da):53,899
Last modified:May 3, 2011 - v1
Checksum:i3049D23C9B903016
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692837 mRNA Translation: ADZ17348.1
CH471052 Genomic DNA Translation: EAW79538.1
RefSeqiNP_071285.1, NM_022002.2
UniGeneiHs.7303

Genome annotation databases

GeneIDi8856

Similar proteinsi

Entry informationi

Entry nameiF1D8P9_HUMAN
AccessioniPrimary (citable) accession number: F1D8P9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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