Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Liver X nuclear receptor beta

Gene

NR1H2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi84 – 161Nuclear receptorPROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Liver X nuclear receptor betaImported
Submitted name:
Nuclear receptor subfamily 1, group H, member 2, isoform CRA_cImported
Gene namesi
Name:NR1H2Imported
ORF Names:hCG_22944Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000131408.

Interactioni

Protein-protein interaction databases

IntActiF1D8P7. 3 interactors.

Structurei

3D structure databases

SMRiF1D8P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 161Nuclear receptor DNA-bindingInterPro annotationAdd BLAST78

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
KOiK08535.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR023257. Liver_X_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F1D8P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD
60 70 80 90 100
EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN
110 120 130 140 150
VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK
160 170 180 190 200
EAGMREQCVL SEEQIRKKKI RKQQQQESQS QSQSPVGPQG SSSSASGPGA
210 220 230 240 250
SPGGSEAGSQ GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK RSFSDQPKVT
260 270 280 290 300
PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ
310 320 330 340 350
IALLKASTIE IMLLETARRY NHETECITFL KDFTYSKDDF HRAGLQVEFI
360 370 380 390 400
NPIFEFSRAM RRLGLDDAEY ALLIAINIFS ADRPNVQEPG RVEALQQPYV
410 420 430 440 450
EALLSYTRIK RPQDQLRFPR MLMKLVSLRT LSSVHSEQVF ALRLQDKKLP
460
PLLSEIWDVH E
Length:461
Mass (Da):51,102
Last modified:May 3, 2011 - v1
Checksum:i68CE3D9F9BC5C0BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692835 mRNA. Translation: ADZ17346.1.
CH471135 Genomic DNA. Translation: EAW71852.1.
CH471135 Genomic DNA. Translation: EAW71853.1.
CH471135 Genomic DNA. Translation: EAW71854.1.
RefSeqiNP_009052.3. NM_007121.5.
UniGeneiHs.432976.

Genome annotation databases

GeneIDi7376.
KEGGihsa:7376.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF1D8P7_HUMAN
AccessioniPrimary (citable) accession number: F1D8P7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 5, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.