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Protein
Submitted name:

Liver X nuclear receptor beta

Gene

NR1H2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi84 – 161Nuclear receptorPROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Liver X nuclear receptor betaImported
Submitted name:
Nuclear receptor subfamily 1, group H, member 2, isoform CRA_cImported
Gene namesi
Name:NR1H2Imported
ORF Names:hCG_22944Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiF1D8P7, 3 interactors

Structurei

3D structure databases

SMRiF1D8P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 161Nuclear receptorInterPro annotationAdd BLAST78
Domaini223 – 461NR LBDInterPro annotationAdd BLAST239

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
KOiK08535

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR023257 Liver_X_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR02034 LIVERXRECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1D8P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD
60 70 80 90 100
EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN
110 120 130 140 150
VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK
160 170 180 190 200
EAGMREQCVL SEEQIRKKKI RKQQQQESQS QSQSPVGPQG SSSSASGPGA
210 220 230 240 250
SPGGSEAGSQ GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK RSFSDQPKVT
260 270 280 290 300
PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ
310 320 330 340 350
IALLKASTIE IMLLETARRY NHETECITFL KDFTYSKDDF HRAGLQVEFI
360 370 380 390 400
NPIFEFSRAM RRLGLDDAEY ALLIAINIFS ADRPNVQEPG RVEALQQPYV
410 420 430 440 450
EALLSYTRIK RPQDQLRFPR MLMKLVSLRT LSSVHSEQVF ALRLQDKKLP
460
PLLSEIWDVH E
Length:461
Mass (Da):51,102
Last modified:May 3, 2011 - v1
Checksum:i68CE3D9F9BC5C0BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692835 mRNA Translation: ADZ17346.1
CH471135 Genomic DNA Translation: EAW71852.1
CH471135 Genomic DNA Translation: EAW71853.1
CH471135 Genomic DNA Translation: EAW71854.1
RefSeqiNP_009052.3, NM_007121.5
UniGeneiHs.432976

Genome annotation databases

GeneIDi7376
KEGGihsa:7376

Similar proteinsi

Entry informationi

Entry nameiF1D8P7_HUMAN
AccessioniPrimary (citable) accession number: F1D8P7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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