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Protein
Submitted name:

RAR-related orphan nuclear receptor variant 2

Gene

NR1F3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
RAR-related orphan nuclear receptor variant 2Imported
Gene namesi
Name:NR1F3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF1D8P6.
PRIDEiF1D8P6.

Expressioni

Gene expression databases

BgeeiF1D8P6.
ExpressionAtlasiF1D8P6. baseline and differential.
GenevisibleiF1D8P6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327025.

Structurei

3D structure databases

ProteinModelPortaliF1D8P6.
SMRiF1D8P6. Positions 10-84, 239-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8276Nuclear receptor DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4216. Eukaryota.
ENOG410XUGR. LUCA.
KOiK08534.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003079. ROR_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1D8P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQRC NAAYSCTRQQ
60 70 80 90 100
NCPIDRTSRN RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLHAEVQKQ
110 120 130 140 150
LQQRQQQQQE PVVKTPPAGA QGADTLTYTL GLPDGQLPLG SSPDLPEASA
160 170 180 190 200
CPPGLLKASG SGPSYSNNLA KAGLNGASCH LEYSPERGKA EGRESFYSTG
210 220 230 240 250
SQLTPDRCGL RFEEHRHPGL GELGQGPDSY GSPSFRSTPE APYASLTEIE
260 270 280 290 300
HLVQSVCKSY RETCQLRLED LLRQRSNIFS REEVTGYQRK SMWEMWERCA
310 320 330 340 350
HHLTEAIQYV VEFAKRLSGF MELCQNDQIV LLKAGAMEVV LVRMCRAYNA
360 370 380 390 400
DNRTVFFEGK YGGMELFRAL GCSELISSIF DFSHSLSALH FSEDEIALYT
410 420 430 440 450
ALVLINAHRP GLQEKRKVEQ LQYNLELAFH HHLCKTHRQS ILAKLPPKGK
460 470 480 490
LRSLCSQHVE RLQIFQHLHP IVVQAAFPPL YKELFSTETE SPVGLSK
Length:497
Mass (Da):55,813
Last modified:May 3, 2011 - v1
Checksum:i6D0048673483EA11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692834 mRNA. Translation: ADZ17345.1.
RefSeqiNP_001001523.1. NM_001001523.1.
UniGeneiHs.256022.
Hs.607993.

Genome annotation databases

GeneIDi6097.
KEGGihsa:6097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692834 mRNA. Translation: ADZ17345.1.
RefSeqiNP_001001523.1. NM_001001523.1.
UniGeneiHs.256022.
Hs.607993.

3D structure databases

ProteinModelPortaliF1D8P6.
SMRiF1D8P6. Positions 10-84, 239-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327025.

Proteomic databases

PaxDbiF1D8P6.
PRIDEiF1D8P6.

Protocols and materials databases

DNASUi6097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6097.
KEGGihsa:6097.

Organism-specific databases

CTDi6097.

Phylogenomic databases

eggNOGiKOG4216. Eukaryota.
ENOG410XUGR. LUCA.
KOiK08534.

Miscellaneous databases

GenomeRNAii6097.

Gene expression databases

BgeeiF1D8P6.
ExpressionAtlasiF1D8P6. baseline and differential.
GenevisibleiF1D8P6. HS.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003079. ROR_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of cDNA coding for multiple human nuclear receptor clones."
    Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.

Entry informationi

Entry nameiF1D8P6_HUMAN
AccessioniPrimary (citable) accession number: F1D8P6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 8, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.