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Protein
Submitted name:

Thyroid hormone nuclear receptor beta variant 1

Gene

NR1A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 181Nuclear receptorPROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Thyroid hormone nuclear receptor beta variant 1Imported
Submitted name:
Thyroid hormone receptor, beta (Erythroblastic leukemia viral (V-erb-a) oncogene homolog 2, avian), isoform CRA_aImported
Gene namesi
Name:NR1A2Imported
Synonyms:THRBImported
ORF Names:hCG_15525Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000151090.17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiF1D8N7

Expressioni

Gene expression databases

BgeeiENSG00000151090
ExpressionAtlasiF1D8N7 baseline and differential

Interactioni

Chemistry databases

BindingDBiF1D8N7

Structurei

3D structure databases

SMRiF1D8N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 181Nuclear receptorInterPro annotationAdd BLAST78
Domaini217 – 461NR LBDInterPro annotationAdd BLAST245

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
KOiK08362
OMAiQEWELIK

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1D8N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK
60 70 80 90 100
NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKNLH PSYSCKYEGK
160 170 180 190 200
CVIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPESETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,788
Last modified:May 3, 2011 - v1
Checksum:i6770BB0D372A7CAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692825 mRNA Translation: ADZ17336.1
CH471055 Genomic DNA Translation: EAW64346.1
CH471055 Genomic DNA Translation: EAW64347.1
CH471055 Genomic DNA Translation: EAW64348.1
CH471055 Genomic DNA Translation: EAW64349.1
RefSeqiNP_000452.2, NM_000461.4
NP_001121648.1, NM_001128176.2
NP_001121649.1, NM_001128177.1
NP_001239563.1, NM_001252634.1
XP_005265478.1, XM_005265421.4
XP_005265480.1, XM_005265423.4
XP_005265481.1, XM_005265424.3
XP_006713380.1, XM_006713317.3
XP_006713381.1, XM_006713318.3
XP_011532348.1, XM_011534046.2
XP_011532349.1, XM_011534047.2
XP_011532350.1, XM_011534048.2
XP_011532351.1, XM_011534049.2
XP_011532352.1, XM_011534050.2
XP_011532353.1, XM_011534051.2
XP_011532354.1, XM_011534052.2
XP_016862597.1, XM_017007108.1
XP_016862598.1, XM_017007109.1
XP_016862599.1, XM_017007110.1
XP_016862600.1, XM_017007111.1
XP_016862601.1, XM_017007112.1
UniGeneiHs.187861
Hs.713754

Genome annotation databases

GeneIDi7068
KEGGihsa:7068

Similar proteinsi

Entry informationi

Entry nameiF1D8N7_HUMAN
AccessioniPrimary (citable) accession number: F1D8N7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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