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Protein
Submitted name:

Thyroid hormone nuclear receptor beta variant 1

Gene

NR1A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Thyroid hormone nuclear receptor beta variant 1Imported
Submitted name:
Thyroid hormone receptor, beta (Erythroblastic leukemia viral (V-erb-a) oncogene homolog 2, avian), isoform CRA_aImported
Gene namesi
Name:NR1A2Imported
Synonyms:THRBImported
ORF Names:hCG_15525Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000151090.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348827.

Structurei

3D structure databases

SMRiF1D8N7. Positions 94-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 18178Nuclear receptor DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation
Contains 1 Nuclear receptor DNA-binding domain.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
KOiK08362.
OMAiWELIKIV.
PhylomeDBiF1D8N7.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1D8N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK
60 70 80 90 100
NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKNLH PSYSCKYEGK
160 170 180 190 200
CVIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPESETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,788
Last modified:May 3, 2011 - v1
Checksum:i6770BB0D372A7CAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692825 mRNA. Translation: ADZ17336.1.
CH471055 Genomic DNA. Translation: EAW64346.1.
CH471055 Genomic DNA. Translation: EAW64347.1.
CH471055 Genomic DNA. Translation: EAW64348.1.
CH471055 Genomic DNA. Translation: EAW64349.1.
RefSeqiNP_000452.2. NM_000461.4.
NP_001121648.1. NM_001128176.2.
NP_001121649.1. NM_001128177.1.
NP_001239563.1. NM_001252634.1.
XP_005265478.1. XM_005265421.4.
XP_005265480.1. XM_005265423.4.
XP_005265481.1. XM_005265424.3.
XP_006713380.1. XM_006713317.3.
XP_006713381.1. XM_006713318.3.
XP_011532348.1. XM_011534046.2.
XP_011532349.1. XM_011534047.2.
XP_011532350.1. XM_011534048.2.
XP_011532351.1. XM_011534049.2.
XP_011532352.1. XM_011534050.2.
XP_011532353.1. XM_011534051.2.
XP_011532354.1. XM_011534052.2.
UniGeneiHs.187861.
Hs.713754.

Genome annotation databases

GeneIDi7068.
KEGGihsa:7068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692825 mRNA. Translation: ADZ17336.1.
CH471055 Genomic DNA. Translation: EAW64346.1.
CH471055 Genomic DNA. Translation: EAW64347.1.
CH471055 Genomic DNA. Translation: EAW64348.1.
CH471055 Genomic DNA. Translation: EAW64349.1.
RefSeqiNP_000452.2. NM_000461.4.
NP_001121648.1. NM_001128176.2.
NP_001121649.1. NM_001128177.1.
NP_001239563.1. NM_001252634.1.
XP_005265478.1. XM_005265421.4.
XP_005265480.1. XM_005265423.4.
XP_005265481.1. XM_005265424.3.
XP_006713380.1. XM_006713317.3.
XP_006713381.1. XM_006713318.3.
XP_011532348.1. XM_011534046.2.
XP_011532349.1. XM_011534047.2.
XP_011532350.1. XM_011534048.2.
XP_011532351.1. XM_011534049.2.
XP_011532352.1. XM_011534050.2.
XP_011532353.1. XM_011534051.2.
XP_011532354.1. XM_011534052.2.
UniGeneiHs.187861.
Hs.713754.

3D structure databases

SMRiF1D8N7. Positions 94-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348827.

Protocols and materials databases

DNASUi7068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7068.
KEGGihsa:7068.

Organism-specific databases

CTDi7068.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
KOiK08362.
OMAiWELIKIV.
PhylomeDBiF1D8N7.

Miscellaneous databases

ChiTaRSiTHRB. human.
GenomeRNAii7068.

Gene expression databases

BgeeiENSG00000151090.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1D8N7_HUMAN
AccessioniPrimary (citable) accession number: F1D8N7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.