ID   F1D8N5_HUMAN            Unreviewed;       388 AA.
AC   F1D8N5;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Androgen nuclear receptor variant 2 {ECO:0000313|EMBL:ADZ17334.1};
GN   Name=NR3C4 {ECO:0000313|EMBL:ADZ17334.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ADZ17334.1};
RN   [1] {ECO:0000313|EMBL:ADZ17334.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Lung {ECO:0000313|EMBL:ADZ17334.1};
RA   Kaighin V.A., Martin A.L., Aronstam R.S.;
RT   "Isolation of cDNA coding for multiple human nuclear receptor clones.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Steroid hormone receptors are ligand-activated transcription
CC       factors that regulate eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues. Transcription
CC       factor activity is modulated by bound coactivator and corepressor
CC       proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen
CC       response elements/ARE on target genes, negatively regulating androgen
CC       receptor signaling and androgen-induced cell proliferation.
CC       Transcription activation is also down-regulated by NR0B2. Activated,
CC       but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
CC       {ECO:0000256|ARBA:ARBA00043923}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU004334}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|RuleBase:RU004334}.
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DR   EMBL; HQ692823; ADZ17334.1; -; mRNA.
DR   RefSeq; NP_001011645.1; NM_001011645.3.
DR   AlphaFoldDB; F1D8N5; -.
DR   SMR; F1D8N5; -.
DR   DNASU; 367; -.
DR   GeneID; 367; -.
DR   HOGENOM; CLU_007368_15_0_1; -.
DR   OrthoDB; 5351241at2759; -.
DR   BioGRID-ORCS; 367; 14 hits in 805 CRISPR screens.
DR   ChiTaRS; AR; human.
DR   GenomeRNAi; 367; -.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd07173; NR_DBD_AR; 1.
DR   CDD; cd07073; NR_LBD_AR; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR48092:SF13; ANDROGEN RECEPTOR; 1.
DR   PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   Genevisible; F1D8N5; HS.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT   DOMAIN          25..100
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          137..368
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
SQ   SEQUENCE   388 AA;  44643 MW;  495BAE974B4EFC75 CRC64;
     MILWLHSLET ARDHVLPIDY YFPPQKTCLI CGDEASGCHY GALTCGSCKV FFKRAAEGKQ
     KYLCASRNDC TIDKFRRKNC PSCRLRKCYE AGMTLGARKL KKLGNLKLQE EGEASSTTSP
     TEETTQKLTV SHIEGYECQP IFLNVLEAIE PGVVCAGHDN NQPDSFAALL SSLNELGERQ
     LVHVVKWAKA LPGFRNLHVD DQMAVIQYSW MGLMVFAMGW RSFTNVNSRM LYFAPDLVFN
     EYRMHKSRMY SQCVRMRHLS QEFGWLQITP QEFLCMKALL LFSIIPVDGL KNQKFFDELR
     MNYIKELDRI IACKRKNPTS CSRRFYQLTK LLDSVQPIAR ELHQFTFDLL IKSHMVSVDF
     PEMMAEIISV QVPKILSGKV KPIYFHTQ
//