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Protein

Acetyl-coenzyme A synthetase

Gene

DICPUDRAFT_51144

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-EC
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
ORF Names:DICPUDRAFT_51144Imported
OrganismiDictyostelium purpureum (Slime mold)Imported
Taxonomic identifieri5786 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000001064 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliF1A288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

InParanoidiF1A288.
KOiK01895.
OMAiFRCLEND.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1A288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSDANIFQP PNFPAKSHIS SIEEYNKLYK ESIENPNDFW DKQAKNFLTW
60 70 80 90 100
FSDYTQVTSG SFQNGDVSWF LNGKINVSYN CIDRHLKENK DKVAIIFEGD
110 120 130 140 150
EATQVQKITY YELYLQVNRL ANVLLSLGIK KGDAVAIYLP NTPIAIYSML
160 170 180 190 200
ACARIGAIHS VIFAGFGYES IVSRVDDAKC RLIITADEGL RGGRYIPLKE
210 220 230 240 250
KIDQVVKHCK SVEHVLVFKN TGRHVNFNSS IDIWADEAMV EQRPYCPPVF
260 270 280 290 300
LDSEDPLFIL YTSGSTGKPK GLVHTQAGYL LYAAMTHRYV FDYQDDDIYA
310 320 330 340 350
CMADVGWITG HSYIVYGPLA NGATTFIFEG TPLHPTPARY WEMVERHKIT
360 370 380 390 400
QFYTAPTAIR SLMKFPVSFT ESSDKSSLRV LGSVGEPINP EAWRWFYNHV
410 420 430 440 450
GQEKCAIVDT YWQTESGGHL ISPLPGATPM KPGSATKPFF GIELRVLDSK
460 470 480 490 500
TGQVITGEKE ASGVLAVARP WPGMARTVFQ SHSRYLTTYM NPYPGHYFTG
510 520 530 540 550
DGVRRDNDGY YWIEGRVDDV INVSGHRLGT AELESALVGC SLCAEAAVVG
560 570 580 590 600
FPHDIKGQGI LAFCTLKQGY EEDESNVIAL LKKEVRTIIG PFATPDVIII
610 620 630 640 650
TPSLPKTRSG KIMRRILRKI GAHESTPEQL GDISTLAEPE VVQLLIDKVS

KVIPKTH
Length:657
Mass (Da):73,392
Last modified:May 3, 2011 - v1
Checksum:i52C0434DB395F0E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL871402 Genomic DNA. Translation: EGC29700.1.
RefSeqiXP_003293782.1. XM_003293734.1.

Genome annotation databases

GeneIDi10505097.
KEGGidpp:DICPUDRAFT_51144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL871402 Genomic DNA. Translation: EGC29700.1.
RefSeqiXP_003293782.1. XM_003293734.1.

3D structure databases

ProteinModelPortaliF1A288.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10505097.
KEGGidpp:DICPUDRAFT_51144.

Phylogenomic databases

InParanoidiF1A288.
KOiK01895.
OMAiFRCLEND.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QSDP1Imported.

Entry informationi

Entry nameiF1A288_DICPU
AccessioniPrimary (citable) accession number: F1A288
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 7, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.