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Protein

DNA ligase

Gene

DICPUDRAFT_81260

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:DICPUDRAFT_81260Imported
OrganismiDictyostelium purpureum (Slime mold)Imported
Taxonomic identifieri5786 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000001064 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi5786.XP_003290530.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 490DNA_LIGASE_A3InterPro annotationAdd BLAST136
Domaini890 – 986BRCTInterPro annotationAdd BLAST97
Domaini1045 – 1143BRCTInterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili852 – 879Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
InParanoidiF0ZSY6
KOiK10776
OMAiSMRFPRI

Family and domain databases

CDDicd00027 BRCT, 2 hits
Gene3Di1.10.3260.10, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 2 hits
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 2 hits
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 2 hits
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F0ZSY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDKSGSLY SLSKLCEKLK EESTHSGKTQ IISSFCKVFN GDLYLLAKLL
60 70 80 90 100
LCKEDKRVFR MRDKVMLKIC AHIWDADLDD MIADLDNGDF TETCKKFYIE
110 120 130 140 150
YGKYPEKSTL TLKQVDDFLD SLTLSGKFDE QVKIISSLLK KCTPQDFRLI
160 170 180 190 200
CRIIDSDLKI NTGAKFFLDA LHPNAYDAYK KANNLHGVIE KIQKHSFESD
210 220 230 240 250
EESDDERSSS SSSNKKKSKK SIDSDDSDNE KSSSKKKSKS KSKSFDVAIK
260 270 280 290 300
LMTPIKPMLP KAVKDVDDVA KSSSCFYSEI KYDGERIQIH KDGNKFSCFS
310 320 330 340 350
RNLKPLMPWK VDEVKQYIPK ATKANQMILD GEVLLMDTKT GIPLPFGTLG
360 370 380 390 400
AHKKKGFIDA TVCVFLFDIL YLDGKSLIHL PLEERREILE KNVTVVKHRV
410 420 430 440 450
EFSEVTIVKG IQEKYKLTNL LNRAFKEKLE GLVIKNADSI YEPGARHWIK
460 470 480 490 500
VKKDYIKGMA DSADLIAIGG YYGSGSFGGL VTVFLMACYD KVSKRYKTVV
510 520 530 540 550
KASGGLDDKT IDKLQPKIKE TMKKISKDHT KVPDWIDINK PYTPDFIVEH
560 570 580 590 600
PRDAMILEIE SAELTKTNYH TSGYSMRFPR IVRFREDKDY KTATNLQELM
610 620 630 640 650
ELGKDAKIIP TDDIEGEFDD ENLIAKRNKK KSLSITATTS TTTTTTTSSK
660 670 680 690 700
SKDKDQQQSD NEEEDSKTKD KLFYVGGDLT QPFSGSGDTS PNIFVLNYVD
710 720 730 740 750
NTDKWNNKGI SGAISKRFPK VVESFEKIKS GESKSEKVLE ENIDKEKKKI
760 770 780 790 800
FVCNLSCIVP PKSKDESYSF SLKHFKSAIK ESKGVIKNKN GSVHIAKPSF
810 820 830 840 850
SKPSWSEIEE VLIDELYDSG IKVFVHSIKS PPSVSKTSTL SSKTTTIDVS
860 870 880 890 900
VNNNNNNNKN ENENEKTSLK RDRDQMLEHE ILKELEEKEL EAPVFGNVNV
910 920 930 940 950
VFDQSVLDNQ KLAKKCERLI KILGGRVSEK WCAIKGLDKT THLICDDGES
960 970 980 990 1000
DLYHHVSRLG GAIAKTQWVE DCFNNDLLLP IDEIYCYVSK NGSSTSQNHS
1010 1020 1030 1040 1050
SKSLDTNTTK NSNAMQIDKL GESTSTSKKE EKQCKSSPSP TKKQHLLNIF
1060 1070 1080 1090 1100
SDCSIYLHEN VNDRDTLKRY IVAFGGDVVD QINEKTTHLI ASLPPNFSTV
1110 1120 1130 1140
KPKDLFKQFL QQNKTHNKKI GNSLWLWDSI NMGEVLDIKS YKLF
Length:1,144
Mass (Da):129,457
Last modified:May 3, 2011 - v1
Checksum:i9E6CFEC950E9ECED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL871165 Genomic DNA Translation: EGC32964.1
RefSeqiXP_003290530.1, XM_003290482.1

Genome annotation databases

EnsemblProtistsiEGC32964; EGC32964; DICPUDRAFT_81260
GeneIDi10507925
KEGGidpp:DICPUDRAFT_81260

Similar proteinsi

Entry informationi

Entry nameiF0ZSY6_DICPU
AccessioniPrimary (citable) accession number: F0ZSY6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health