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F0ZAC4

- F0ZAC4_DICPU

UniProt

F0ZAC4 - F0ZAC4_DICPU

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Protein
Isocitrate dehydrogenase [NADP]
Gene
DICPUDRAFT_52874
Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarityUniRule annotation
Binding sitei71 – 711NADP By similarity
Binding sitei98 – 981Substrate By similarityUniRule annotation
Binding sitei121 – 1211Substrate By similarityUniRule annotation
Sitei128 – 1281Critical for catalysis By similarityUniRule annotation
Sitei199 – 1991Critical for catalysis By similarityUniRule annotation
Metal bindingi239 – 2391Magnesium or manganese By similarityUniRule annotation
Binding sitei247 – 2471NADP By similarity
Metal bindingi262 – 2621Magnesium or manganese By similarityUniRule annotation
Binding sitei314 – 3141NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 663NADP By similarity
Nucleotide bindingi296 – 3016NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:DICPUDRAFT_52874Imported
OrganismiDictyostelium purpureum (Slime mold)
Taxonomic identifieri5786 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000001064: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliF0ZAC4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 897Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiKVSREFY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0ZAC4-1 [UniParc]FASTAAdd to Basket

« Hide

MDGDEMTRVI WESIKKKLVF PFVDFKDIQY FDLGLPNRDA TNDKVTIDSA    50
NATKLAKVAI KCATITPDEA RVKEFQLKEM WKSPNGTIRN IIGGTVFREP 100
IICKNIPLLV PGWKKPIVIG RHAHADQYKA TDFVVSSPGK LEMVFTPENG 150
EPIKREVYQY KGKGVAMGMY NTDESIIEFA HSCFKYALNR DYPLYLSTKN 200
TILKKYDGRF KDIFQEIYEK NYKQQFADKN IWYEHRLIDD MVAYALKSQG 250
GYVWACKNYD GDVQSDIVAQ GFGSLGLMTS VLLGPNNVLE AEAAHGTVTR 300
HFREYQKGNE TSTNPVASIF AWTRGLSHRA KLDNNTKLAE FCKGLEDACI 350
KTIEDGHMTK DLAICIKGEK VSRSDYLNTQ DFIDKISETY LASSK 395
Length:395
Mass (Da):44,822
Last modified:May 3, 2011 - v1
Checksum:i65075EFDDB634145
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL870963 Genomic DNA. Translation: EGC39127.1.
RefSeqiXP_003284379.1. XM_003284331.1.

Genome annotation databases

GeneIDi10510285.
KEGGidpp:DICPUDRAFT_52874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL870963 Genomic DNA. Translation: EGC39127.1 .
RefSeqi XP_003284379.1. XM_003284331.1.

3D structure databases

ProteinModelPortali F0ZAC4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10510285.
KEGGi dpp:DICPUDRAFT_52874.

Phylogenomic databases

KOi K00031.
OMAi KVSREFY.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QSDP1.

Entry informationi

Entry nameiF0ZAC4_DICPU
AccessioniPrimary (citable) accession number: F0ZAC4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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