Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

DICPUDRAFT_52874

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661SubstrateUniRule annotation
Binding sitei71 – 711NADPUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Sitei128 – 1281Critical for catalysisUniRule annotation
Sitei199 – 1991Critical for catalysisUniRule annotation
Metal bindingi239 – 2391Magnesium or manganeseUniRule annotation
Binding sitei247 – 2471NADPUniRule annotation
Metal bindingi262 – 2621Magnesium or manganeseUniRule annotation
Binding sitei314 – 3141NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 663NADPUniRule annotation
Nucleotide bindingi296 – 3016NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:DICPUDRAFT_52874Imported
OrganismiDictyostelium purpureum (Slime mold)Imported
Taxonomic identifieri5786 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000001064 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5786.XP_003284379.1.

Structurei

3D structure databases

ProteinModelPortaliF0ZAC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 897Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiF0ZAC4.
KOiK00031.
OMAiINNIPRI.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0ZAC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDEMTRVI WESIKKKLVF PFVDFKDIQY FDLGLPNRDA TNDKVTIDSA
60 70 80 90 100
NATKLAKVAI KCATITPDEA RVKEFQLKEM WKSPNGTIRN IIGGTVFREP
110 120 130 140 150
IICKNIPLLV PGWKKPIVIG RHAHADQYKA TDFVVSSPGK LEMVFTPENG
160 170 180 190 200
EPIKREVYQY KGKGVAMGMY NTDESIIEFA HSCFKYALNR DYPLYLSTKN
210 220 230 240 250
TILKKYDGRF KDIFQEIYEK NYKQQFADKN IWYEHRLIDD MVAYALKSQG
260 270 280 290 300
GYVWACKNYD GDVQSDIVAQ GFGSLGLMTS VLLGPNNVLE AEAAHGTVTR
310 320 330 340 350
HFREYQKGNE TSTNPVASIF AWTRGLSHRA KLDNNTKLAE FCKGLEDACI
360 370 380 390
KTIEDGHMTK DLAICIKGEK VSRSDYLNTQ DFIDKISETY LASSK
Length:395
Mass (Da):44,822
Last modified:May 3, 2011 - v1
Checksum:i65075EFDDB634145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL870963 Genomic DNA. Translation: EGC39127.1.
RefSeqiXP_003284379.1. XM_003284331.1.

Genome annotation databases

GeneIDi10510285.
KEGGidpp:DICPUDRAFT_52874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL870963 Genomic DNA. Translation: EGC39127.1.
RefSeqiXP_003284379.1. XM_003284331.1.

3D structure databases

ProteinModelPortaliF0ZAC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5786.XP_003284379.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10510285.
KEGGidpp:DICPUDRAFT_52874.

Phylogenomic databases

InParanoidiF0ZAC4.
KOiK00031.
OMAiINNIPRI.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QSDP1Imported.

Entry informationi

Entry nameiF0ZAC4_DICPU
AccessioniPrimary (citable) accession number: F0ZAC4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 22, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.