Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F0ZAC4 (F0ZAC4_DICPU) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:DICPUDRAFT_52874 EMBL EGC39127.1
OrganismDictyostelium purpureum (Slime mold) [Reference proteome]
Taxonomic identifier5786 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding64 – 663NADP By similarity
Nucleotide binding296 – 3016NADP By similarity
Region83 – 897Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2391Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2621Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site661Substrate By similarity PIRSR PIRSR000108-2
Binding site711NADP By similarity
Binding site981Substrate By similarity PIRSR PIRSR000108-2
Binding site1211Substrate By similarity PIRSR PIRSR000108-2
Binding site2471NADP By similarity
Binding site3141NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1281Critical for catalysis By similarity PIRSR PIRSR000108-1
Site1991Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
F0ZAC4 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 65075EFDDB634145

FASTA39544,822
        10         20         30         40         50         60 
MDGDEMTRVI WESIKKKLVF PFVDFKDIQY FDLGLPNRDA TNDKVTIDSA NATKLAKVAI 

        70         80         90        100        110        120 
KCATITPDEA RVKEFQLKEM WKSPNGTIRN IIGGTVFREP IICKNIPLLV PGWKKPIVIG 

       130        140        150        160        170        180 
RHAHADQYKA TDFVVSSPGK LEMVFTPENG EPIKREVYQY KGKGVAMGMY NTDESIIEFA 

       190        200        210        220        230        240 
HSCFKYALNR DYPLYLSTKN TILKKYDGRF KDIFQEIYEK NYKQQFADKN IWYEHRLIDD 

       250        260        270        280        290        300 
MVAYALKSQG GYVWACKNYD GDVQSDIVAQ GFGSLGLMTS VLLGPNNVLE AEAAHGTVTR 

       310        320        330        340        350        360 
HFREYQKGNE TSTNPVASIF AWTRGLSHRA KLDNNTKLAE FCKGLEDACI KTIEDGHMTK 

       370        380        390 
DLAICIKGEK VSRSDYLNTQ DFIDKISETY LASSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GL870963 Genomic DNA. Translation: EGC39127.1.
RefSeqXP_003284379.1. XM_003284331.1.

3D structure databases

ProteinModelPortalF0ZAC4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10510285.
KEGGdpp:DICPUDRAFT_52874.

Phylogenomic databases

KOK00031.
OMAKVSREFY.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0ZAC4_DICPU
AccessionPrimary (citable) accession number: F0ZAC4
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)