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Protein

Isocitrate dehydrogenase [NADP]

Gene

DICPUDRAFT_52874

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66SubstrateUniRule annotation1
Binding sitei71NADPUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Sitei128Critical for catalysisUniRule annotation1
Sitei199Critical for catalysisUniRule annotation1
Metal bindingi239Magnesium or manganeseUniRule annotation1
Binding sitei247NADPUniRule annotation1
Metal bindingi262Magnesium or manganeseUniRule annotation1
Binding sitei314NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 66NADPUniRule annotation3
Nucleotide bindingi296 – 301NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:DICPUDRAFT_52874Imported
OrganismiDictyostelium purpureum (Slime mold)Imported
Taxonomic identifieri5786 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000001064 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5786.XP_003284379.1

Structurei

3D structure databases

ProteinModelPortaliF0ZAC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 386Iso_dhInterPro annotationAdd BLAST386

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 89Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526 Eukaryota
COG0538 LUCA
InParanoidiF0ZAC4
KOiK00031
OMAiIQKRWPL

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

F0ZAC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDEMTRVI WESIKKKLVF PFVDFKDIQY FDLGLPNRDA TNDKVTIDSA
60 70 80 90 100
NATKLAKVAI KCATITPDEA RVKEFQLKEM WKSPNGTIRN IIGGTVFREP
110 120 130 140 150
IICKNIPLLV PGWKKPIVIG RHAHADQYKA TDFVVSSPGK LEMVFTPENG
160 170 180 190 200
EPIKREVYQY KGKGVAMGMY NTDESIIEFA HSCFKYALNR DYPLYLSTKN
210 220 230 240 250
TILKKYDGRF KDIFQEIYEK NYKQQFADKN IWYEHRLIDD MVAYALKSQG
260 270 280 290 300
GYVWACKNYD GDVQSDIVAQ GFGSLGLMTS VLLGPNNVLE AEAAHGTVTR
310 320 330 340 350
HFREYQKGNE TSTNPVASIF AWTRGLSHRA KLDNNTKLAE FCKGLEDACI
360 370 380 390
KTIEDGHMTK DLAICIKGEK VSRSDYLNTQ DFIDKISETY LASSK
Length:395
Mass (Da):44,822
Last modified:May 3, 2011 - v1
Checksum:i65075EFDDB634145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL870963 Genomic DNA Translation: EGC39127.1
RefSeqiXP_003284379.1, XM_003284331.1

Genome annotation databases

EnsemblProtistsiEGC39127; EGC39127; DICPUDRAFT_52874
GeneIDi10510285
KEGGidpp:DICPUDRAFT_52874

Similar proteinsi

Entry informationi

Entry nameiF0ZAC4_DICPU
AccessioniPrimary (citable) accession number: F0ZAC4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health