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F0ZAC4

- F0ZAC4_DICPU

UniProt

F0ZAC4 - F0ZAC4_DICPU

Protein

Isocitrate dehydrogenase [NADP]

Gene

DICPUDRAFT_52874

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei71 – 711NADPUniRule annotation
    Binding sitei98 – 981SubstrateUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation
    Sitei128 – 1281Critical for catalysisUniRule annotation
    Sitei199 – 1991Critical for catalysisUniRule annotation
    Metal bindingi239 – 2391Magnesium or manganese
    Binding sitei247 – 2471NADPUniRule annotation
    Metal bindingi262 – 2621Magnesium or manganese
    Binding sitei314 – 3141NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 663NADPUniRule annotation
    Nucleotide bindingi296 – 3016NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:DICPUDRAFT_52874Imported
    OrganismiDictyostelium purpureum (Slime mold)Imported
    Taxonomic identifieri5786 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000001064: Unassembled WGS sequence

    Structurei

    3D structure databases

    ProteinModelPortaliF0ZAC4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni83 – 897Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKVSREFY.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0ZAC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGDEMTRVI WESIKKKLVF PFVDFKDIQY FDLGLPNRDA TNDKVTIDSA    50
    NATKLAKVAI KCATITPDEA RVKEFQLKEM WKSPNGTIRN IIGGTVFREP 100
    IICKNIPLLV PGWKKPIVIG RHAHADQYKA TDFVVSSPGK LEMVFTPENG 150
    EPIKREVYQY KGKGVAMGMY NTDESIIEFA HSCFKYALNR DYPLYLSTKN 200
    TILKKYDGRF KDIFQEIYEK NYKQQFADKN IWYEHRLIDD MVAYALKSQG 250
    GYVWACKNYD GDVQSDIVAQ GFGSLGLMTS VLLGPNNVLE AEAAHGTVTR 300
    HFREYQKGNE TSTNPVASIF AWTRGLSHRA KLDNNTKLAE FCKGLEDACI 350
    KTIEDGHMTK DLAICIKGEK VSRSDYLNTQ DFIDKISETY LASSK 395
    Length:395
    Mass (Da):44,822
    Last modified:May 3, 2011 - v1
    Checksum:i65075EFDDB634145
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL870963 Genomic DNA. Translation: EGC39127.1.
    RefSeqiXP_003284379.1. XM_003284331.1.

    Genome annotation databases

    GeneIDi10510285.
    KEGGidpp:DICPUDRAFT_52874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL870963 Genomic DNA. Translation: EGC39127.1 .
    RefSeqi XP_003284379.1. XM_003284331.1.

    3D structure databases

    ProteinModelPortali F0ZAC4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10510285.
    KEGGi dpp:DICPUDRAFT_52874.

    Phylogenomic databases

    KOi K00031.
    OMAi KVSREFY.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: QSDP1Imported.

    Entry informationi

    Entry nameiF0ZAC4_DICPU
    AccessioniPrimary (citable) accession number: F0ZAC4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3