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F0ZAC4

- F0ZAC4_DICPU

UniProt

F0ZAC4 - F0ZAC4_DICPU

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Protein

Isocitrate dehydrogenase [NADP]

Gene

DICPUDRAFT_52874

Organism
Dictyostelium purpureum (Slime mold)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661SubstrateUniRule annotation
Binding sitei71 – 711NADPUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Sitei128 – 1281Critical for catalysisUniRule annotation
Sitei199 – 1991Critical for catalysisUniRule annotation
Metal bindingi239 – 2391Magnesium or manganese
Binding sitei247 – 2471NADPUniRule annotation
Metal bindingi262 – 2621Magnesium or manganese
Binding sitei314 – 3141NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 663NADPUniRule annotation
Nucleotide bindingi296 – 3016NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:DICPUDRAFT_52874Imported
OrganismiDictyostelium purpureum (Slime mold)Imported
Taxonomic identifieri5786 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000001064: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliF0ZAC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 897Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiF0ZAC4.
KOiK00031.
OMAiKVSREFY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0ZAC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGDEMTRVI WESIKKKLVF PFVDFKDIQY FDLGLPNRDA TNDKVTIDSA
60 70 80 90 100
NATKLAKVAI KCATITPDEA RVKEFQLKEM WKSPNGTIRN IIGGTVFREP
110 120 130 140 150
IICKNIPLLV PGWKKPIVIG RHAHADQYKA TDFVVSSPGK LEMVFTPENG
160 170 180 190 200
EPIKREVYQY KGKGVAMGMY NTDESIIEFA HSCFKYALNR DYPLYLSTKN
210 220 230 240 250
TILKKYDGRF KDIFQEIYEK NYKQQFADKN IWYEHRLIDD MVAYALKSQG
260 270 280 290 300
GYVWACKNYD GDVQSDIVAQ GFGSLGLMTS VLLGPNNVLE AEAAHGTVTR
310 320 330 340 350
HFREYQKGNE TSTNPVASIF AWTRGLSHRA KLDNNTKLAE FCKGLEDACI
360 370 380 390
KTIEDGHMTK DLAICIKGEK VSRSDYLNTQ DFIDKISETY LASSK
Length:395
Mass (Da):44,822
Last modified:May 3, 2011 - v1
Checksum:i65075EFDDB634145
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL870963 Genomic DNA. Translation: EGC39127.1.
RefSeqiXP_003284379.1. XM_003284331.1.

Genome annotation databases

GeneIDi10510285.
KEGGidpp:DICPUDRAFT_52874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL870963 Genomic DNA. Translation: EGC39127.1 .
RefSeqi XP_003284379.1. XM_003284331.1.

3D structure databases

ProteinModelPortali F0ZAC4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10510285.
KEGGi dpp:DICPUDRAFT_52874.

Phylogenomic databases

InParanoidi F0ZAC4.
KOi K00031.
OMAi KVSREFY.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: QSDP1Imported.

Entry informationi

Entry nameiF0ZAC4_DICPU
AccessioniPrimary (citable) accession number: F0ZAC4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3