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F0XS04 (DAPB_GROCL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:CMQ_7762
OrganismGrosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera) [Complete proteome]
Taxonomic identifier655863 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeOphiostomatalesOphiostomataceaeGrosmannia

Protein attributes

Sequence length975 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 975975Probable dipeptidyl-aminopeptidase B
PRO_0000412146

Regions

Topological domain1 – 125125Cytoplasmic Potential
Transmembrane126 – 14621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain147 – 975829Vacuolar Potential
Compositional bias496 – 5016Poly-Val
Compositional bias661 – 6688Poly-Ala

Sites

Active site8261Charge relay system By similarity
Active site9031Charge relay system By similarity
Active site9361Charge relay system By similarity

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential
Glycosylation6221N-linked (GlcNAc...) Potential
Glycosylation8851N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
F0XS04 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 487AC28233F1D863

FASTA975106,581
        10         20         30         40         50         60 
MAEHGHNMWE EEPSKGRDSL DSDSSASTTS LVFDQISERV AAESGTTKGK RMRYGHDEAD 

        70         80         90        100        110        120 
LGARLSELDD EDPLKDEASG DYDLETGPFL GGHGHNSNHD GLSAASGSAG KTQGGYRMMD 

       130        140        150        160        170        180 
RGLRRVLIIA SLVFVTAWVG GLFIYISHKS YLHGSEFEHD PQATVSRGSL RKITREQVDN 

       190        200        210        220        230        240 
GFWRPVKASI AWVAGPAGED GLLLETNASG ASDKAYLTVQ DVRSLQQGLD ASTEAAVAAA 

       250        260        270        280        290        300 
RRTLVEKSTF TFAGKTYRIG SSKASKDMSK VLLGVDVQSN WRHSSTAAYF ILEVATQTVQ 

       310        320        330        340        350        360 
PLIPGEVSAR VQLAQWSPQS DAIAFTRDNN LYFRQVVAGS SSSAEDADSV IKQITTDGGP 

       370        380        390        400        410        420 
ELFYGVPDWV YEEEVLGGAS ATWWSPDGRY IAFLRTNETG VPEYPVQYFL HRPSGAAPAE 

       430        440        450        460        470        480 
GEENYPEVRQ IKYPKAGAHN PVVDLQFFDV GRGDSFSVAV SGEFADENRL ITTVLWAGAQ 

       490        500        510        520        530        540 
KVLVKETNRV STVMRVVVVD VAARSGQAVR TVDVGAIDGG WFEISQRTRF IPADPARQRP 

       550        560        570        580        590        600 
DDGYIDTIVH NNGDHLAYFS PPENPEPIML TAGPDWEVDD APAAVDLERN LVYFLATIQG 

       610        620        630        640        650        660 
ITQRHLYSVR LLDGGGLSPL TNTSEPGFYG ASFSAGVGAG YVLLEYGGPN IPWQKVMNTP 

       670        680        690        700        710        720 
AAAAAAAAGS ADVSKQMPFV HVLEDNHELA ERARQYALPL LVRGTFDVKG HDEGVGAGKL 

       730        740        750        760        770        780 
NYLERRPPHF DPSKKYPVLF QQYSGPGSQE VTHEFSVDFQ SYVAASLGYV VVTVDPRGTG 

       790        800        810        820        830        840 
FAGRSNRVVV RGRLGVVESH DHIAAAQHWA SLPYIDGDRL AIWGWSYGGF TTLKTLEQDA 

       850        860        870        880        890        900 
GRTFRYGIAV APVTDWRFYD SVYTERYMDT PQANAVGYDT GAVTNASALA QNVRFLIMHG 

       910        920        930        940        950        960 
IADDNVHLQN SLALLDRLDI EGVSNYDVHV FPDSDHSIYF HNGRQIVYDK LENWLINAFN 

       970 
GEWLKIDNAK PQGKR 

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References

[1]"Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen."
DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N., Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M., Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A., Marra M.A. expand/collapse author list , Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.
Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: kw1407 / UAMH 11150.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GL629990 Genomic DNA. Translation: EFW99394.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_GROCL
AccessionPrimary (citable) accession number: F0XS04
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 3, 2011
Last modified: April 16, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries