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F0XS04

- DAPB_GROCL

UniProt

F0XS04 - DAPB_GROCL

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, CMQ_7762
Organism
Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei826 – 8261Charge relay system By similarity
Active sitei903 – 9031Charge relay system By similarity
Active sitei936 – 9361Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:CMQ_7762
OrganismiGrosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
Taxonomic identifieri655863 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeOphiostomatalesOphiostomataceaeGrosmannia
ProteomesiUP000007796: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 125125Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini147 – 975829Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 975975Probable dipeptidyl-aminopeptidase B
PRO_0000412146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi885 – 8851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi496 – 5016Poly-Val
Compositional biasi661 – 6688Poly-Ala

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

F0XS04-1 [UniParc]FASTAAdd to Basket

« Hide

MAEHGHNMWE EEPSKGRDSL DSDSSASTTS LVFDQISERV AAESGTTKGK    50
RMRYGHDEAD LGARLSELDD EDPLKDEASG DYDLETGPFL GGHGHNSNHD 100
GLSAASGSAG KTQGGYRMMD RGLRRVLIIA SLVFVTAWVG GLFIYISHKS 150
YLHGSEFEHD PQATVSRGSL RKITREQVDN GFWRPVKASI AWVAGPAGED 200
GLLLETNASG ASDKAYLTVQ DVRSLQQGLD ASTEAAVAAA RRTLVEKSTF 250
TFAGKTYRIG SSKASKDMSK VLLGVDVQSN WRHSSTAAYF ILEVATQTVQ 300
PLIPGEVSAR VQLAQWSPQS DAIAFTRDNN LYFRQVVAGS SSSAEDADSV 350
IKQITTDGGP ELFYGVPDWV YEEEVLGGAS ATWWSPDGRY IAFLRTNETG 400
VPEYPVQYFL HRPSGAAPAE GEENYPEVRQ IKYPKAGAHN PVVDLQFFDV 450
GRGDSFSVAV SGEFADENRL ITTVLWAGAQ KVLVKETNRV STVMRVVVVD 500
VAARSGQAVR TVDVGAIDGG WFEISQRTRF IPADPARQRP DDGYIDTIVH 550
NNGDHLAYFS PPENPEPIML TAGPDWEVDD APAAVDLERN LVYFLATIQG 600
ITQRHLYSVR LLDGGGLSPL TNTSEPGFYG ASFSAGVGAG YVLLEYGGPN 650
IPWQKVMNTP AAAAAAAAGS ADVSKQMPFV HVLEDNHELA ERARQYALPL 700
LVRGTFDVKG HDEGVGAGKL NYLERRPPHF DPSKKYPVLF QQYSGPGSQE 750
VTHEFSVDFQ SYVAASLGYV VVTVDPRGTG FAGRSNRVVV RGRLGVVESH 800
DHIAAAQHWA SLPYIDGDRL AIWGWSYGGF TTLKTLEQDA GRTFRYGIAV 850
APVTDWRFYD SVYTERYMDT PQANAVGYDT GAVTNASALA QNVRFLIMHG 900
IADDNVHLQN SLALLDRLDI EGVSNYDVHV FPDSDHSIYF HNGRQIVYDK 950
LENWLINAFN GEWLKIDNAK PQGKR 975
Length:975
Mass (Da):106,581
Last modified:May 3, 2011 - v1
Checksum:i487AC28233F1D863
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL629990 Genomic DNA. Translation: EFW99394.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL629990 Genomic DNA. Translation: EFW99394.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: kw1407 / UAMH 11150.

Entry informationi

Entry nameiDAPB_GROCL
AccessioniPrimary (citable) accession number: F0XS04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi