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F0XS04

- DAPB_GROCL

UniProt

F0XS04 - DAPB_GROCL

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei826 – 8261Charge relay systemBy similarity
    Active sitei903 – 9031Charge relay systemBy similarity
    Active sitei936 – 9361Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:CMQ_7762
    OrganismiGrosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
    Taxonomic identifieri655863 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeOphiostomatalesOphiostomataceaeGrosmannia
    ProteomesiUP000007796: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 975975Probable dipeptidyl-aminopeptidase BPRO_0000412146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi885 – 8851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 125125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 975829VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei126 – 14621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi496 – 5016Poly-Val
    Compositional biasi661 – 6688Poly-Ala

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F0XS04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEHGHNMWE EEPSKGRDSL DSDSSASTTS LVFDQISERV AAESGTTKGK    50
    RMRYGHDEAD LGARLSELDD EDPLKDEASG DYDLETGPFL GGHGHNSNHD 100
    GLSAASGSAG KTQGGYRMMD RGLRRVLIIA SLVFVTAWVG GLFIYISHKS 150
    YLHGSEFEHD PQATVSRGSL RKITREQVDN GFWRPVKASI AWVAGPAGED 200
    GLLLETNASG ASDKAYLTVQ DVRSLQQGLD ASTEAAVAAA RRTLVEKSTF 250
    TFAGKTYRIG SSKASKDMSK VLLGVDVQSN WRHSSTAAYF ILEVATQTVQ 300
    PLIPGEVSAR VQLAQWSPQS DAIAFTRDNN LYFRQVVAGS SSSAEDADSV 350
    IKQITTDGGP ELFYGVPDWV YEEEVLGGAS ATWWSPDGRY IAFLRTNETG 400
    VPEYPVQYFL HRPSGAAPAE GEENYPEVRQ IKYPKAGAHN PVVDLQFFDV 450
    GRGDSFSVAV SGEFADENRL ITTVLWAGAQ KVLVKETNRV STVMRVVVVD 500
    VAARSGQAVR TVDVGAIDGG WFEISQRTRF IPADPARQRP DDGYIDTIVH 550
    NNGDHLAYFS PPENPEPIML TAGPDWEVDD APAAVDLERN LVYFLATIQG 600
    ITQRHLYSVR LLDGGGLSPL TNTSEPGFYG ASFSAGVGAG YVLLEYGGPN 650
    IPWQKVMNTP AAAAAAAAGS ADVSKQMPFV HVLEDNHELA ERARQYALPL 700
    LVRGTFDVKG HDEGVGAGKL NYLERRPPHF DPSKKYPVLF QQYSGPGSQE 750
    VTHEFSVDFQ SYVAASLGYV VVTVDPRGTG FAGRSNRVVV RGRLGVVESH 800
    DHIAAAQHWA SLPYIDGDRL AIWGWSYGGF TTLKTLEQDA GRTFRYGIAV 850
    APVTDWRFYD SVYTERYMDT PQANAVGYDT GAVTNASALA QNVRFLIMHG 900
    IADDNVHLQN SLALLDRLDI EGVSNYDVHV FPDSDHSIYF HNGRQIVYDK 950
    LENWLINAFN GEWLKIDNAK PQGKR 975
    Length:975
    Mass (Da):106,581
    Last modified:May 3, 2011 - v1
    Checksum:i487AC28233F1D863
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL629990 Genomic DNA. Translation: EFW99394.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL629990 Genomic DNA. Translation: EFW99394.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: kw1407 / UAMH 11150.

    Entry informationi

    Entry nameiDAPB_GROCL
    AccessioniPrimary (citable) accession number: F0XS04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3