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F0VUQ5 (F0VUQ5_STRG2) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
Gene names
Name:purH HAMAP-Rule MF_00139 EMBL CBZ47202.1
Ordered Locus Names:SGGBAA2069_c00300 EMBL CBZ47202.1
OrganismStreptococcus gallolyticus (strain ATCC BAA-2069) [Complete proteome] [HAMAP] EMBL CBZ47202.1
Taxonomic identifier990317 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139 SAAS SAAS024051

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139 SAAS SAAS024051

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139 SAAS SAAS024051

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. HAMAP-Rule MF_00139 SAAS SAAS024051

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family. HAMAP-Rule MF_00139

Sequences

Sequence LengthMass (Da)Tools
F0VUQ5 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 6774291448A83CB5

FASTA51556,672
        10         20         30         40         50         60 
MTKRALISVS DKAGIVEFAQ ELKKLGWDII STGGTKVALD KAGVDTIAID DVTGFPEMMD 

        70         80         90        100        110        120 
GRVKTLHPNI HGGLLARRDL DSHLQAAKDN HIELIDLVVV NLYPFKETIL KPEVTYADAV 

       130        140        150        160        170        180 
ENIDIGGPSM LRSAAKNHAS VTVVVDPADY AVVLDELSAN GETSFETRQR LAAKVFRHTA 

       190        200        210        220        230        240 
AYDALIAEYF TKQVGETKPE KLTITYDLKQ PMRYGENPQQ DADFYQKALP TDYSIASAKQ 

       250        260        270        280        290        300 
LNGKELSFNN IRDADAAIRI IRDFKDRPTV VALKHMNPCG IGQADDIETA WDYAYESDPV 

       310        320        330        340        350        360 
SIFGGIVVLN REVDAATAKK MHAIFLEIII APSYSEEALE ILTTKKKNLR ILQLPFEAQE 

       370        380        390        400        410        420 
ASQVEKEYTG VVGGLLVQNQ DVVEENPADW KVVTKRQPND QEKTALEFAW KAIKYVKSNG 

       430        440        450        460        470        480 
IIVTNDHMTL GVGPGQTNRV ASVRIALDQA KDRLDGAVLA SDAFFPFADN VEEIAAAGVK 

       490        500        510 
AIIQPGGSVR DQESIDMADK YGIAMVFTGV RHFRH

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References

[1]"Complete genome and comparative analysis of Streptococcus gallolyticus subsp. gallolyticus, an emerging pathogen of infective endocarditis."
Hinse D., Vollmer T., Ruckert C., Blom J., Kalinowski J., Knabbe C., Dreier J.
BMC Genomics 12:400-400(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-2069 EMBL CBZ47202.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FR824043 Genomic DNA. Translation: CBZ47202.1.
RefSeqYP_004286946.1. NC_015215.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBZ47202; CBZ47202; SGGBAA2069_c00300.
GeneID10294180.
KEGGsgg:SGGBAA2069_c00300.
PATRIC47025751. VBIStrGal182109_0030.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00602.

Enzyme and pathway databases

BioCycSGAL990317:GI5F-2079-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
SSF52335. MGS-like_dom. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF0VUQ5_STRG2
AccessionPrimary (citable) accession number: F0VUQ5
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 3, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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