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Protein

Elongation factor Tu

Gene

tuf

Organism
Lactobacillus acidophilus (strain 30SC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPUniRule annotation
Nucleotide bindingi82 – 865GTPUniRule annotation
Nucleotide bindingi137 – 1404GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotation, HydrolaseImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLACI891391:GHOY-882-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:LAC30SC_04240Imported
OrganismiLactobacillus acidophilus (strain 30SC)Imported
Taxonomic identifieri891391 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000007491: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

KOiK02358.
OMAiHYRPQLF.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0TDZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEHYVRT KPHVNIGTIG HVDHGKTTLT AAITTVLAEK GLAKAEDYSQ
60 70 80 90 100
IDAAPEEKER GITINTAHVE YETENRHYAH MDAPGHADYI KNMITGAAQM
110 120 130 140 150
DGAILVVAAT DGPMPQTREH ILLARQVGVN YIVVFLNKCD LVDDPELIDL
160 170 180 190 200
VEMEVRDLLT EYDYPGDDIP VVRGSALKAL QGDKEAQEQI LKLMDIVDEY
210 220 230 240 250
IPTPERQTDK PFLMPVEDVF TITGRGTVAS GRIDRGTVKI GDEVEIVGLV
260 270 280 290 300
DKVLKSVVTG LEMFHKTLDL GEAGDNVGVL LRGIDRDQVV RGQVLAAPGS
310 320 330 340 350
IQTHEKFKGQ VYVLKKDEGG RHTPFFSDYR PQFYFHTTDI TGEIELPEGT
360 370 380 390
EMVMPGDNTE FTVTLIKPAA IEKGTKFTIR EGGRTVGAGQ VTEILD
Length:396
Mass (Da):43,590
Last modified:May 3, 2011 - v1
Checksum:iE602B747E98352C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002559 Genomic DNA. Translation: ADZ07013.1.
RefSeqiYP_004291952.1. NC_015214.1.

Genome annotation databases

EnsemblBacteriaiADZ07013; ADZ07013; LAC30SC_04240.
GeneIDi10275189.
KEGGilai:LAC30SC_04240.
PATRICi46964455. VBILacAci171603_0838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002559 Genomic DNA. Translation: ADZ07013.1.
RefSeqiYP_004291952.1. NC_015214.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADZ07013; ADZ07013; LAC30SC_04240.
GeneIDi10275189.
KEGGilai:LAC30SC_04240.
PATRICi46964455. VBILacAci171603_0838.

Phylogenomic databases

KOiK02358.
OMAiHYRPQLF.

Enzyme and pathway databases

BioCyciLACI891391:GHOY-882-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequencing of Lactobacillus acidophilus 30SC, isolated from swine intestine."
    Oh S., Roh H., Ko H.J., Kim S., Kim K.H., Lee S.E., Chang I.S., Kim S., Choi I.G.
    J. Bacteriol. 193:2882-2883(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 30SCImported.
  2. Roh H., Ko H.-J., Kim S.-H., Choi I.-G., Oh S.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 30SC.

Entry informationi

Entry nameiF0TDZ2_LACA3
AccessioniPrimary (citable) accession number: F0TDZ2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 7, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.